Vitamin D Deficiency Is Associated with Advanced Liver Fibrosis and Impaired Fasting Glucose in Alcohol Use Disorder

Background: Vitamin D deficiency is a risk factor for liver disease, insulin resistance, and beta cell dysfunction. Individuals with alcohol use disorder (AUD) have many comorbidities, with a heavy burden of liver disease and metabolic complications, including type 2 diabetes mellitus (T2DM). Object...

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Detalhes bibliográficos
Autores: Zuluaga Blanco, Yenny Paola|||0000-0002-0247-0351, Casado-Carbajo, Julia, Hernandez Rubio, Anna|||0000-0001-8612-7827, Bueno-Vélez, Marvin, García-Martin, Carmen, Muga, Roberto|||0000-0001-6301-431X, Fuster, Daniel|||0000-0003-1262-5860
Formato: artículo
Fecha de publicación:2024
País:España
Recursos:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:311595
Acesso em linha:https://ddd.uab.cat/record/311595
https://dx.doi.org/urn:doi:10.3390/nu16081099
Access Level:acceso abierto
Palavra-chave:Vitamin D
Alcohol use disorder
Fasting glucose
Advanced liver fibrosis
Descrição
Resumo:Background: Vitamin D deficiency is a risk factor for liver disease, insulin resistance, and beta cell dysfunction. Individuals with alcohol use disorder (AUD) have many comorbidities, with a heavy burden of liver disease and metabolic complications, including type 2 diabetes mellitus (T2DM). Objective: We aimed to analyze the prevalence and associations of vitamin D deficiency in patients admitted for in-hospital treatment of AUD. Methods: A cross-sectional study was conducted in patients consecutively admitted for the treatment of AUD between January 2017 and October 2023. Sociodemographic data, substance use characteristics, and blood parameters were available at admission. Vitamin D status was assessed through the serum concentrations of 25-hydroxyvitamin D [25(OH)D] levels using a direct competitive chemiluminescent immunoassay method. Deficiency of vitamin D was defined as a concentration less than 20 ng/mL; impaired fasting glucose (IFG) was defined by fasting blood glucose.