Ni-Catalyzed Reductive Coupling of Alkynes with Aziridines

Herein, we describe a Ni-catalyzed regioselective hydroalkenylation of alkynes with aziridines as coupling partners. This protocol allows access to homoallylic amines without recourse to stoichiometric amounts of well-defined organometallic reagents via catalytic regioselective ring-opening of aziri...

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Detalhes bibliográficos
Autores: Zimin, Dmitry P., Zhang, Liangliang, Janssen-Müller, Daniel, Day, Craig S., Davies, Jacob, Wakeling, Matthew, Martin, Ruben
Tipo de documento: artigo
Data de publicação:2025
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositório:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2072/484675
Acesso em linha:http://hdl.handle.net/2072/484675
http://dx.doi.org/10.1055/a-2640-8380
Access Level:Acesso embargado
Palavra-chave:Química
54
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spelling Ni-Catalyzed Reductive Coupling of Alkynes with AziridinesZimin, Dmitry P.Zhang, LiangliangJanssen-Müller, DanielDay, Craig S.Davies, JacobWakeling, MatthewMartin, RubenQuímica54Herein, we describe a Ni-catalyzed regioselective hydroalkenylation of alkynes with aziridines as coupling partners. This protocol allows access to homoallylic amines without recourse to stoichiometric amounts of well-defined organometallic reagents via catalytic regioselective ring-opening of aziridines under mild reaction conditions. The protocol is characterized by its applicability across a wide variety of aziridines or alkynes, including challenging substrate combinations.info:eu-repo/semantics/acceptedVersionThieme2025info:eu-repo/semantics/article5 p.application/pdfhttp://hdl.handle.net/2072/484675http://dx.doi.org/10.1055/a-2640-8380RECERCAT (Dipòsit de la Recerca de Catalunya)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésL. Z. thanks the Deutsche Forshungsgemeinschaft (DFG) for a postdoctoral fellowshipFEDER/MCI(PID2021-123801NB-I00) and MCI/AIE (Severo Ochoa Excellence Accreditation CEX2019-000925-S)Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/embargoedAccessoai:recercat.cat:2072/4846752026-05-29T05:05:01Z
dc.title.none.fl_str_mv Ni-Catalyzed Reductive Coupling of Alkynes with Aziridines
title Ni-Catalyzed Reductive Coupling of Alkynes with Aziridines
spellingShingle Ni-Catalyzed Reductive Coupling of Alkynes with Aziridines
Zimin, Dmitry P.
Química
54
title_short Ni-Catalyzed Reductive Coupling of Alkynes with Aziridines
title_full Ni-Catalyzed Reductive Coupling of Alkynes with Aziridines
title_fullStr Ni-Catalyzed Reductive Coupling of Alkynes with Aziridines
title_full_unstemmed Ni-Catalyzed Reductive Coupling of Alkynes with Aziridines
title_sort Ni-Catalyzed Reductive Coupling of Alkynes with Aziridines
dc.creator.none.fl_str_mv Zimin, Dmitry P.
Zhang, Liangliang
Janssen-Müller, Daniel
Day, Craig S.
Davies, Jacob
Wakeling, Matthew
Martin, Ruben
author Zimin, Dmitry P.
author_facet Zimin, Dmitry P.
Zhang, Liangliang
Janssen-Müller, Daniel
Day, Craig S.
Davies, Jacob
Wakeling, Matthew
Martin, Ruben
author_role author
author2 Zhang, Liangliang
Janssen-Müller, Daniel
Day, Craig S.
Davies, Jacob
Wakeling, Matthew
Martin, Ruben
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Química
54
topic Química
54
description Herein, we describe a Ni-catalyzed regioselective hydroalkenylation of alkynes with aziridines as coupling partners. This protocol allows access to homoallylic amines without recourse to stoichiometric amounts of well-defined organometallic reagents via catalytic regioselective ring-opening of aziridines under mild reaction conditions. The protocol is characterized by its applicability across a wide variety of aziridines or alkynes, including challenging substrate combinations.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/2072/484675
http://dx.doi.org/10.1055/a-2640-8380
url http://hdl.handle.net/2072/484675
http://dx.doi.org/10.1055/a-2640-8380
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv L. Z. thanks the Deutsche Forshungsgemeinschaft (DFG) for a postdoctoral fellowship
FEDER/MCI(PID2021-123801NB-I00) and MCI/AIE (Severo Ochoa Excellence Accreditation CEX2019-000925-S)
dc.rights.none.fl_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/embargoedAccess
rights_invalid_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv embargoedAccess
dc.format.none.fl_str_mv 5 p.
application/pdf
dc.publisher.none.fl_str_mv Thieme
publisher.none.fl_str_mv Thieme
dc.source.none.fl_str_mv RECERCAT (Dipòsit de la Recerca de Catalunya)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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