Ni-Catalyzed Reductive Coupling of Alkynes with Aziridines

Herein, we describe a Ni-catalyzed regioselective hydroalkenylation of alkynes with aziridines as coupling partners. This protocol allows access to homoallylic amines without recourse to stoichiometric amounts of well-defined organometallic reagents via catalytic regioselective ring-opening of aziri...

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Detalhes bibliográficos
Autores: Zimin, Dmitry P., Zhang, Liangliang, Janssen-Müller, Daniel, Day, Craig S., Davies, Jacob, Wakeling, Matthew, Martin, Ruben
Tipo de documento: artigo
Data de publicação:2025
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositório:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2072/484675
Acesso em linha:http://hdl.handle.net/2072/484675
http://dx.doi.org/10.1055/a-2640-8380
Access Level:Acesso embargado
Palavra-chave:Química
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Descrição
Resumo:Herein, we describe a Ni-catalyzed regioselective hydroalkenylation of alkynes with aziridines as coupling partners. This protocol allows access to homoallylic amines without recourse to stoichiometric amounts of well-defined organometallic reagents via catalytic regioselective ring-opening of aziridines under mild reaction conditions. The protocol is characterized by its applicability across a wide variety of aziridines or alkynes, including challenging substrate combinations.