Implications of gut and oral microbiota in neuroinflammatory responses in Alzheimer's disease

[EN] A diverse and stable microbiota promotes a healthy state, nevertheless, an imbalance in gut or oral bacterial composition, called dysbiosis, can cause gastrointestinal disorders, systemic inflammatory states and oxidative stress, among others. Recently, gut and oral dysbiosis has been linked to...

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Detalhes bibliográficos
Autores: Bello-Corral, Laura, Alves-Gomes, Lisa, Fernández Fernández , Jesús Antonio, Fernández García, Daniel, Casado Verdejo, Inés, Sánchez Valdeón, Leticia
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Recursos:Universidad Rey Juan Carlos
Repositorio:BULERIA. Repositorio Institucional de la Universidad de León
OAI Identifier:oai:buleria.unileon.es:10612/17288
Acesso em linha:https://hdl.handle.net/10612/17288
Access Level:acceso abierto
Palavra-chave:Enfermería
Alzheimer's
Gut microbiota
Oral microbiota
Dysbiosis
Neuroinflammation
NLRP3
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spelling Implications of gut and oral microbiota in neuroinflammatory responses in Alzheimer's diseaseBello-Corral, LauraAlves-Gomes, LisaFernández Fernández , Jesús AntonioFernández García, DanielCasado Verdejo, InésSánchez Valdeón, LeticiaEnfermeríaAlzheimer'sGut microbiotaOral microbiotaDysbiosisNeuroinflammationNLRP3[EN] A diverse and stable microbiota promotes a healthy state, nevertheless, an imbalance in gut or oral bacterial composition, called dysbiosis, can cause gastrointestinal disorders, systemic inflammatory states and oxidative stress, among others. Recently, gut and oral dysbiosis has been linked to Alzheimer's disease (AD), which is considered the most common form of dementia and a public health priority due to its high prevalence and incidence. The aim of this review is to highlight the implications of gut and oral microbiota in the neuroinflammation characteristic of AD pathology and the subsequent cognitive impairment. It is a systematic review of the current literature obtained by searching the PubMed, Web of Science and Scopus databases. The characteristic intestinal dysbiosis in AD patients leads to increased permeability of the intestinal barrier and activates immune cells in the central nervous system due to translocation of microbiota-derived metabolites and/or bacteria into the circulation leading to increased neuroinflammation and neuronal loss, thus generating the cognitive impairment characteristic of AD. The presence in the central nervous system of Porphyromonas gingivalis can cause an increased neuroinflammation and beta-amyloid peptide accumulation.SIElsevierEnfermeriaEscuela Universitaria de Ciencias de la Salud2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://hdl.handle.net/10612/17288reponame:BULERIA. Repositorio Institucional de la Universidad de Leóninstname:Universidad Rey Juan CarlosIngléshttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:buleria.unileon.es:10612/172882026-06-24T12:43:27Z
dc.title.none.fl_str_mv Implications of gut and oral microbiota in neuroinflammatory responses in Alzheimer's disease
title Implications of gut and oral microbiota in neuroinflammatory responses in Alzheimer's disease
spellingShingle Implications of gut and oral microbiota in neuroinflammatory responses in Alzheimer's disease
Bello-Corral, Laura
Enfermería
Alzheimer's
Gut microbiota
Oral microbiota
Dysbiosis
Neuroinflammation
NLRP3
title_short Implications of gut and oral microbiota in neuroinflammatory responses in Alzheimer's disease
title_full Implications of gut and oral microbiota in neuroinflammatory responses in Alzheimer's disease
title_fullStr Implications of gut and oral microbiota in neuroinflammatory responses in Alzheimer's disease
title_full_unstemmed Implications of gut and oral microbiota in neuroinflammatory responses in Alzheimer's disease
title_sort Implications of gut and oral microbiota in neuroinflammatory responses in Alzheimer's disease
dc.creator.none.fl_str_mv Bello-Corral, Laura
Alves-Gomes, Lisa
Fernández Fernández , Jesús Antonio
Fernández García, Daniel
Casado Verdejo, Inés
Sánchez Valdeón, Leticia
author Bello-Corral, Laura
author_facet Bello-Corral, Laura
Alves-Gomes, Lisa
Fernández Fernández , Jesús Antonio
Fernández García, Daniel
Casado Verdejo, Inés
Sánchez Valdeón, Leticia
author_role author
author2 Alves-Gomes, Lisa
Fernández Fernández , Jesús Antonio
Fernández García, Daniel
Casado Verdejo, Inés
Sánchez Valdeón, Leticia
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Enfermeria
Escuela Universitaria de Ciencias de la Salud
dc.subject.none.fl_str_mv Enfermería
Alzheimer's
Gut microbiota
Oral microbiota
Dysbiosis
Neuroinflammation
NLRP3
topic Enfermería
Alzheimer's
Gut microbiota
Oral microbiota
Dysbiosis
Neuroinflammation
NLRP3
description [EN] A diverse and stable microbiota promotes a healthy state, nevertheless, an imbalance in gut or oral bacterial composition, called dysbiosis, can cause gastrointestinal disorders, systemic inflammatory states and oxidative stress, among others. Recently, gut and oral dysbiosis has been linked to Alzheimer's disease (AD), which is considered the most common form of dementia and a public health priority due to its high prevalence and incidence. The aim of this review is to highlight the implications of gut and oral microbiota in the neuroinflammation characteristic of AD pathology and the subsequent cognitive impairment. It is a systematic review of the current literature obtained by searching the PubMed, Web of Science and Scopus databases. The characteristic intestinal dysbiosis in AD patients leads to increased permeability of the intestinal barrier and activates immune cells in the central nervous system due to translocation of microbiota-derived metabolites and/or bacteria into the circulation leading to increased neuroinflammation and neuronal loss, thus generating the cognitive impairment characteristic of AD. The presence in the central nervous system of Porphyromonas gingivalis can cause an increased neuroinflammation and beta-amyloid peptide accumulation.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/10612/17288
url https://hdl.handle.net/10612/17288
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:BULERIA. Repositorio Institucional de la Universidad de León
instname:Universidad Rey Juan Carlos
instname_str Universidad Rey Juan Carlos
reponame_str BULERIA. Repositorio Institucional de la Universidad de León
collection BULERIA. Repositorio Institucional de la Universidad de León
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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