Oral Microbiota, Its Equilibrium and Implications in the Pathophysiology of Human Diseases: A Systematic Review
Imbalances of the oral microbiota and dysbiosis have traditionally been linked to theoccurrence of teeth and oral diseases. However, recent findings indicate that this microbiota exertsrelevant influence in systemic health. Dysbiosis of the oral microbiota is implicated in the apparitionand progress...
| Autores: | , , , , , , |
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| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2022 |
| País: | España |
| Recursos: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:10459.1/83912 |
| Acesso em linha: | https://doi.org/10.3390/biomedicines10081803 http://hdl.handle.net/10459.1/83912 |
| Access Level: | acceso abierto |
| Palavra-chave: | Oral microbiota Gut microbiota Caries Periodontal disease Dysbiosis Cardiovasculardisease Neurodegeneration Alzheimer’s disease |
| Resumo: | Imbalances of the oral microbiota and dysbiosis have traditionally been linked to theoccurrence of teeth and oral diseases. However, recent findings indicate that this microbiota exertsrelevant influence in systemic health. Dysbiosis of the oral microbiota is implicated in the apparitionand progression of cardiovascular, neurodegenerative and other major human diseases. In fact,the oral microbiota are the second most diverse and largely populated microbiota of the humanbody and its relationships with systemic health, although widely explored, they still lack of properintegration. The purpose of this systematic review is thus to widely examine the implications of oralmicrobiota in oral, cardiovascular and neurodegenerative diseases to offer integrative and up-to-dateinterpretations. To achieve that aim, we identified a total of 121 studies curated in PUBMED from thetime interval January 2003–April 2022, which after careful screening resulted in 79 studies included.The reviewed scientific literature provides plausible vias of implication of dysbiotic oral microbiota insystemic human diseases, and encourages further research to continue elucidating the highly relevantand still poorly understood implications of this niche microbiota in systemic health. PROSPERORegistration Number: CRD42022299692. This systematic review follows relevant PRISMA guidelines. |
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