Electro-responsive hyaluronic acid-based click-hydrogels for wound healing

With the aim of healing challenging skin wounds, electro-responsive click-hydrogels made of hyaluronic acid (clickHA) crosslinked with a modified polyethylene glycol precursor (PEG) were prepared by semi-interpenetrating a conducting polymer, poly(hydroxymethyl-3,4-ethylenedioxythiophene) (PEDOT-MeO...

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Detalles Bibliográficos
Autores: Castrejón Comas, Víctor, Mataró, Nil, Resina, Maria Leonor Matos|||0000-0003-4216-8349, Zanuy Gomara, David|||0000-0001-7704-2178, Nuñez Aulina, Quim, Sánchez Morán, Joel, Enshaei, Hamidreza, Arnau Roca, Marc|||0000-0001-6038-3902, Muñoz Galan, Helena|||0000-0003-2550-0047, Worch, Josh, Dove, Andrew, Alemán Llansó, Carlos|||0000-0003-4462-6075, Pérez Madrigal, Maria del Mar|||0000-0002-2498-8485
Tipo de recurso: artículo
Fecha de publicación:2025
País:España
Institución:Universitat Politècnica de Catalunya (UPC)
Repositorio:UPCommons. Portal del coneixement obert de la UPC
Idioma:inglés
OAI Identifier:oai:upcommons.upc.edu:2117/425801
Acceso en línea:https://hdl.handle.net/2117/425801
https://dx.doi.org/10.1016/j.carbpol.2024.122941
Access Level:acceso abierto
Palabra clave:Click hydrogel
Hyaluronic acid
Wound dressing
Conducting polymer
Poly(3
4-ethylenedioxythiophene)
Àrees temàtiques de la UPC::Enginyeria química::Química orgànica::Bioquímica
Descripción
Sumario:With the aim of healing challenging skin wounds, electro-responsive click-hydrogels made of hyaluronic acid (clickHA) crosslinked with a modified polyethylene glycol precursor (PEG) were prepared by semi-interpenetrating a conducting polymer, poly(hydroxymethyl-3,4-ethylenedioxythiophene) (PEDOT-MeOH) by oxidative polymerization. The porosity and pore size of the mixed hydrogel, clickHA/PEDOT-MeOH, were both higher than those determined for the hydrogel without PEDOT-MeOH, while a honeycomb-like morphology with PEDOT-MeOH covering the pore walls was observed. Although such PEDOT-MeOH-induced changes did not influence the water absorption capacity of clickHA, they drastically affected the mechanical and electrochemical behavior. More specifically, the semi-interpenetration of PEDOT-MeOH into clickHA resulted in an increase of the Young's modulus, the compressive strength and, especially, the electrochemical activity. The biocompatibility and the potential for skin regeneration of clickHA/PEDOT-MeOH were preliminary assessed using viability and wound-healing assays with epithelial cells. Not only is the conducting hydrogel formulation biocompatible, but also promotes efficient cell migration by electrostimulation using a small voltage (0.5 V) for a short time (15 min). Thus, in just 1 h the wound gap was repaired, and a homogeneous monolayer of migrated cells was formed.

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