Effects of Virgin Olive Oils Differing in Their Bioactive Compound Contents on Metabolic Syndrome and Endothelial Functional Risk Biomarkers in Healthy Adults: A Randomized Double-Blind Controlled Trial

17 Páginas; 3 Figuras; 5 Tablas

Detalles Bibliográficos
Autores: Sánchez Rodríguez, Estefanía, Lima Cabello, Elena, Biel-Glesson, Sara, Fernández-Navarro, José Ramón, Calleja, Miguel A., Roca, María, Espejo-Calvo, Juan Antonio, Gil-Extremera, Blas, Soria-Florido, María Trinidad, Torre, Rafael de la, Fitó, Montserrat, Covas, María Isabel, Alché Ramírez, Juan de Dios, Martínez de Victoria, Emilio, Gil, Ángel, Mesa, María D.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/165020
Acceso en línea:http://hdl.handle.net/10261/165020
Access Level:acceso abierto
Palabra clave:Olive oil
Virgin olive oil
Olive oil polyphenols
Maslinic acid
Oleanolic acid
Cardiovascular diseases
Endothelial function
Phenolic compounds
Triterpenes
Metabolic syndrome
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spelling Effects of Virgin Olive Oils Differing in Their Bioactive Compound Contents on Metabolic Syndrome and Endothelial Functional Risk Biomarkers in Healthy Adults: A Randomized Double-Blind Controlled TrialSánchez Rodríguez, EstefaníaLima Cabello, ElenaBiel-Glesson, SaraFernández-Navarro, José RamónCalleja, Miguel A.Roca, MaríaEspejo-Calvo, Juan AntonioGil-Extremera, BlasSoria-Florido, María TrinidadTorre, Rafael de laFitó, MontserratCovas, María IsabelAlché Ramírez, Juan de DiosMartínez de Victoria, EmilioGil, ÁngelMesa, María D.Olive oilVirgin olive oilOlive oil polyphenolsMaslinic acidOleanolic acidCardiovascular diseasesEndothelial functionPhenolic compoundsTriterpenesMetabolic syndrome17 Páginas; 3 Figuras; 5 TablasThe aim of this study was to evaluate the effect of virgin olive oils (VOOs) enriched with phenolic compounds and triterpenes on metabolic syndrome and endothelial function biomarkers in healthy adults. The trial was a three-week randomized, crossover, controlled, double-blind, intervention study involving 58 subjects supplemented with a daily dose (30 mL) of three oils: (1) a VOO (124 ppm of phenolic compounds and 86 ppm of triterpenes); (2) an optimized VOO (OVOO) (490 ppm of phenolic compounds and 86 ppm of triterpenes); and (3) a functional olive oil (FOO) high in phenolic compounds (487 ppm) and enriched with triterpenes (389 ppm). Metabolic syndrome and endothelial function biomarkers were determined in vivo and ex vivo. Plasma high density lipoprotein cholesterol (HDLc) increased after the OVOO intake. Plasma endothelin-1 levels decreased after the intake of the three olive oils, and in blood cell cultures challenged. Daily intake of VOO enriched in phenolic compounds improved plasma HDLc, although no differences were found at the end of the three interventions, while VOO with at least 124 ppm of phenolic compounds, regardless of the triterpenes content improved the systemic endothelin-1 levels in vivo and ex vivo. No effect of triterpenes was observed after three weeks of interventions. Results need to be confirmed in subjects with metabolic syndrome and impaired endothelial function (Clinical Trials number NCT02520739).The “NUTRAOLEUM Study” has been supported by the grant ITC-20131031 from the I+D FEDER-INTERCONNECTA (CDTI) and Junta de Andalucía, Spain”. We thank ACER CAMPESTRES S.L., SAN FRANCISCO DE ASIS Coop and AGROINSUR S.L., for the funding provided. The authors thank Pilar Jiménez, Alberto Guarnido, María Molina and Elizabeth García for administering the questionnaires to the subjects; Isabel Mérida, Isabel Hinojosa, Agustín Martín García, and María Luz Abarca for collecting the biological samples; and Victoria Martín Laguna and Laura Campaña Martín for aliquoting the samples. The authors also thank María Cruz Rico Prados for sample analysis and Llenalia M. García Fernández for her contributions to the statistical analysis.Peer reviewedMultidisciplinary Digital Publishing InstituteCentro para el Desarrollo Tecnológico Industrial (España)Junta de AndalucíaConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]201820182018info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/165020reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.3390/nu10050626Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1650202026-05-22T06:33:51Z
dc.title.none.fl_str_mv Effects of Virgin Olive Oils Differing in Their Bioactive Compound Contents on Metabolic Syndrome and Endothelial Functional Risk Biomarkers in Healthy Adults: A Randomized Double-Blind Controlled Trial
title Effects of Virgin Olive Oils Differing in Their Bioactive Compound Contents on Metabolic Syndrome and Endothelial Functional Risk Biomarkers in Healthy Adults: A Randomized Double-Blind Controlled Trial
spellingShingle Effects of Virgin Olive Oils Differing in Their Bioactive Compound Contents on Metabolic Syndrome and Endothelial Functional Risk Biomarkers in Healthy Adults: A Randomized Double-Blind Controlled Trial
Sánchez Rodríguez, Estefanía
Olive oil
Virgin olive oil
Olive oil polyphenols
Maslinic acid
Oleanolic acid
Cardiovascular diseases
Endothelial function
Phenolic compounds
Triterpenes
Metabolic syndrome
title_short Effects of Virgin Olive Oils Differing in Their Bioactive Compound Contents on Metabolic Syndrome and Endothelial Functional Risk Biomarkers in Healthy Adults: A Randomized Double-Blind Controlled Trial
title_full Effects of Virgin Olive Oils Differing in Their Bioactive Compound Contents on Metabolic Syndrome and Endothelial Functional Risk Biomarkers in Healthy Adults: A Randomized Double-Blind Controlled Trial
title_fullStr Effects of Virgin Olive Oils Differing in Their Bioactive Compound Contents on Metabolic Syndrome and Endothelial Functional Risk Biomarkers in Healthy Adults: A Randomized Double-Blind Controlled Trial
title_full_unstemmed Effects of Virgin Olive Oils Differing in Their Bioactive Compound Contents on Metabolic Syndrome and Endothelial Functional Risk Biomarkers in Healthy Adults: A Randomized Double-Blind Controlled Trial
title_sort Effects of Virgin Olive Oils Differing in Their Bioactive Compound Contents on Metabolic Syndrome and Endothelial Functional Risk Biomarkers in Healthy Adults: A Randomized Double-Blind Controlled Trial
dc.creator.none.fl_str_mv Sánchez Rodríguez, Estefanía
Lima Cabello, Elena
Biel-Glesson, Sara
Fernández-Navarro, José Ramón
Calleja, Miguel A.
Roca, María
Espejo-Calvo, Juan Antonio
Gil-Extremera, Blas
Soria-Florido, María Trinidad
Torre, Rafael de la
Fitó, Montserrat
Covas, María Isabel
Alché Ramírez, Juan de Dios
Martínez de Victoria, Emilio
Gil, Ángel
Mesa, María D.
author Sánchez Rodríguez, Estefanía
author_facet Sánchez Rodríguez, Estefanía
Lima Cabello, Elena
Biel-Glesson, Sara
Fernández-Navarro, José Ramón
Calleja, Miguel A.
Roca, María
Espejo-Calvo, Juan Antonio
Gil-Extremera, Blas
Soria-Florido, María Trinidad
Torre, Rafael de la
Fitó, Montserrat
Covas, María Isabel
Alché Ramírez, Juan de Dios
Martínez de Victoria, Emilio
Gil, Ángel
Mesa, María D.
author_role author
author2 Lima Cabello, Elena
Biel-Glesson, Sara
Fernández-Navarro, José Ramón
Calleja, Miguel A.
Roca, María
Espejo-Calvo, Juan Antonio
Gil-Extremera, Blas
Soria-Florido, María Trinidad
Torre, Rafael de la
Fitó, Montserrat
Covas, María Isabel
Alché Ramírez, Juan de Dios
Martínez de Victoria, Emilio
Gil, Ángel
Mesa, María D.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Centro para el Desarrollo Tecnológico Industrial (España)
Junta de Andalucía
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Olive oil
Virgin olive oil
Olive oil polyphenols
Maslinic acid
Oleanolic acid
Cardiovascular diseases
Endothelial function
Phenolic compounds
Triterpenes
Metabolic syndrome
topic Olive oil
Virgin olive oil
Olive oil polyphenols
Maslinic acid
Oleanolic acid
Cardiovascular diseases
Endothelial function
Phenolic compounds
Triterpenes
Metabolic syndrome
description 17 Páginas; 3 Figuras; 5 Tablas
publishDate 2018
dc.date.none.fl_str_mv 2018
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/165020
url http://hdl.handle.net/10261/165020
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.3390/nu10050626
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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