Synthesis of new azino fused benzimidazolium salts. A new family of DNA intercalating agents. l
A series of new pyrido[1,2-a]- and pyridazino[1,6-a]benzimidazolium salts have been synthesized from readily available 1,3-disubstituted 2-alkylbenzimidazolium salts. Their affinity to DNA and in vitro cytotoxicity versus HT-29 have been tested. The initial results show that the title compounds are...
| Autores: | , , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 1995 |
| País: | España |
| Institución: | Universidad de Alcalá (UAH) |
| Repositorio: | e_Buah Biblioteca Digital Universidad de Alcalá |
| Idioma: | inglés |
| OAI Identifier: | oai:ebuah.uah.es:10017/3436 |
| Acceso en línea: | http://hdl.handle.net/10017/3436 https://dx.doi.org/10.1016/0960-894X(95)00532-4 |
| Access Level: | acceso abierto |
| Palabra clave: | Westphal condensation Deoxyribonucleic-acid Drugs Derivatives Kinetics Analogs Chemistry, Medicinal Chemistry, Organic Ciencia Química orgánica Science Chemistry, organic |
| Sumario: | A series of new pyrido[1,2-a]- and pyridazino[1,6-a]benzimidazolium salts have been synthesized from readily available 1,3-disubstituted 2-alkylbenzimidazolium salts. Their affinity to DNA and in vitro cytotoxicity versus HT-29 have been tested. The initial results show that the title compounds are a new family of intercalating agents. |
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