Optimized synthesis of di, tri and tetrafused pyridazinium cations
By combining two complementary statistical techniques (fractional factorial experimental design and simplex operation) the synthesis of the parent pyrido[1,2-b]-pyridazinium cation has been successfully carried out (the yield was improved from less than 10 to 65%) by basic condensation of 2-methyl-1...
| Autores: | , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2000 |
| País: | España |
| Institución: | Universidad de Alcalá (UAH) |
| Repositorio: | e_Buah Biblioteca Digital Universidad de Alcalá |
| Idioma: | inglés |
| OAI Identifier: | oai:ebuah.uah.es:10017/4192 |
| Acceso en línea: | http://hdl.handle.net/10017/4192 https://dx.doi.org/10.1016/S0040-4020(00)00079-X |
| Access Level: | acceso abierto |
| Palabra clave: | Westphal Condensations Computer-assisted methods Polycyclic heterocyclic ions Ciencia Química orgánica Science Chemistry, organic |
| Sumario: | By combining two complementary statistical techniques (fractional factorial experimental design and simplex operation) the synthesis of the parent pyrido[1,2-b]-pyridazinium cation has been successfully carried out (the yield was improved from less than 10 to 65%) by basic condensation of 2-methyl-1-aminopyridinium mesitylenesulfonate and [1,4]dioxane-2,3-diol. Using the optimized reaction conditions, other related heterocyclic cations could be prepared, and two interesting examples are now reported. |
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