Alcoholic liver disease among patients with Wernicke Encephalopathy: a multicenter observational study
[EN] Background: data regarding the association between Wernicke encephalopathy (WE) and alcoholic liver disease (ALD) are scarce in spite of alcohol consumption being the main risk factor for WE. Aims: to describe the frequency of ALD in a cohort of patients diagnosed with WE and alcohol use disord...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2022 |
| País: | España |
| Institución: | Universidad de Salamanca (USAL) |
| Repositorio: | GREDOS. Repositorio Institucional de la Universidad de Salamanca |
| OAI Identifier: | oai:gredos.usal.es:10366/159462 |
| Acceso en línea: | http://hdl.handle.net/10366/159462 |
| Access Level: | acceso abierto |
| Palabra clave: | Wernicke encephalopathy Alcoholic liver disease Alcohol use disorders Wernicke Encephalopathy 3205 Medicina Interna encefalopatía de Wernicke |
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oai:gredos.usal.es:10366/159462 |
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Alcoholic liver disease among patients with Wernicke Encephalopathy: a multicenter observational studyNovo Veleiro, IgnacioHerrera-Flores, JavierRosón Hernández, BeatrizMedina García, José-A.Muga Bustamante, RobertoFernández Solá, JoaquínMartín González, M. CandelariaSeco Hernández, ElenaSuárez Cuervo, CarlosMateos Díaz, Ana MaríaMonte Secades, RafaelMachado Prieto, BegoñaPuerta Louro, RubénPrada González, CristinaFernández Rial, ÁlvaroSabio Repiso, PatriciaVázquez Vigo, RocíoAntolí Royo, Ana CristinaGomila Grange, AinaFelipe Pérez, Nieves-C.Sanvisens Bergé, ArantzaAntúnez Jorge, EmiliaFernández Rodríguez, Camino-M.Alvela-Suárez, LucíaFidalgo Navarro, AlbaCastro, JoaquínPolvorosa Gómez, María A.del Valle Sánchez, MarioLopez Castro, JoséChamorro Fernández, Antonio JavierMarcos Martín, MiguelWernicke encephalopathyAlcoholic liver diseaseAlcohol use disordersWernicke Encephalopathy3205 Medicina Internaencefalopatía de Wernicke[EN] Background: data regarding the association between Wernicke encephalopathy (WE) and alcoholic liver disease (ALD) are scarce in spite of alcohol consumption being the main risk factor for WE. Aims: to describe the frequency of ALD in a cohort of patients diagnosed with WE and alcohol use disorders (AUDs) and to compare the characteristics of WE patients with and without ALD. Methods: we conducted an observational study in 21 centers through a nationwide registry of the Spanish Society of Internal Medicine. WE Caine criteria were applied and demographic, clinical, and outcome variables were analyzed. Results: 434 patients were included in the study, of which 372 were men (85.7%), and the mean age was 55 ± 11.8 years. ALD was present in 162 (37.3%) patients and we found a higher percentage of cases with tremor, flapping and hallucinations in the ALD group. A total of 22 patients (5.0%) died during admission (7.4% with ALD vs 3.7% without ALD; P = 0.087). Among the ALD patients, a relationship between mortality and the presence of anemia (Odds ratio [OR]=4.6 Confidence interval [CI]95% 1.1–18.8; P = 0.034), low level of consciousness (OR=4.9 CI95% 1.1–21.2; P = 0.031) and previous diagnosis of cancer (OR=10.3 CI95% 1.8–59.5; P = 0.009) was detected. Complete recovery was achieved by 27 patients with ALD (17.8%) and 71 (27.8%) without ALD (P = 0.030). Conclusion: the association of WE and ALD in patients with AUDs is frequent and potentially linked to differences in clinical presentation and to poorer prognosis, as compared to alcoholic patients with WE without ALD.Publicación en abierto financiada por la Universidad de Salamanca como participante en el Acuerdo Transformativo CRUE-CSIC con Elsevier, 2021-2024Elsevier202420242022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10366/159462reponame:GREDOS. Repositorio Institucional de la Universidad de Salamancainstname:Universidad de Salamanca (USAL)InglésAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:gredos.usal.es:10366/1594622026-06-07T06:28:51Z |
| dc.title.none.fl_str_mv |
Alcoholic liver disease among patients with Wernicke Encephalopathy: a multicenter observational study |
| title |
Alcoholic liver disease among patients with Wernicke Encephalopathy: a multicenter observational study |
| spellingShingle |
Alcoholic liver disease among patients with Wernicke Encephalopathy: a multicenter observational study Novo Veleiro, Ignacio Wernicke encephalopathy Alcoholic liver disease Alcohol use disorders Wernicke Encephalopathy 3205 Medicina Interna encefalopatía de Wernicke |
| title_short |
Alcoholic liver disease among patients with Wernicke Encephalopathy: a multicenter observational study |
| title_full |
Alcoholic liver disease among patients with Wernicke Encephalopathy: a multicenter observational study |
| title_fullStr |
Alcoholic liver disease among patients with Wernicke Encephalopathy: a multicenter observational study |
| title_full_unstemmed |
Alcoholic liver disease among patients with Wernicke Encephalopathy: a multicenter observational study |
| title_sort |
Alcoholic liver disease among patients with Wernicke Encephalopathy: a multicenter observational study |
| dc.creator.none.fl_str_mv |
Novo Veleiro, Ignacio Herrera-Flores, Javier Rosón Hernández, Beatriz Medina García, José-A. Muga Bustamante, Roberto Fernández Solá, Joaquín Martín González, M. Candelaria Seco Hernández, Elena Suárez Cuervo, Carlos Mateos Díaz, Ana María Monte Secades, Rafael Machado Prieto, Begoña Puerta Louro, Rubén Prada González, Cristina Fernández Rial, Álvaro Sabio Repiso, Patricia Vázquez Vigo, Rocío Antolí Royo, Ana Cristina Gomila Grange, Aina Felipe Pérez, Nieves-C. Sanvisens Bergé, Arantza Antúnez Jorge, Emilia Fernández Rodríguez, Camino-M. Alvela-Suárez, Lucía Fidalgo Navarro, Alba Castro, Joaquín Polvorosa Gómez, María A. del Valle Sánchez, Mario Lopez Castro, José Chamorro Fernández, Antonio Javier Marcos Martín, Miguel |
| author |
Novo Veleiro, Ignacio |
| author_facet |
Novo Veleiro, Ignacio Herrera-Flores, Javier Rosón Hernández, Beatriz Medina García, José-A. Muga Bustamante, Roberto Fernández Solá, Joaquín Martín González, M. Candelaria Seco Hernández, Elena Suárez Cuervo, Carlos Mateos Díaz, Ana María Monte Secades, Rafael Machado Prieto, Begoña Puerta Louro, Rubén Prada González, Cristina Fernández Rial, Álvaro Sabio Repiso, Patricia Vázquez Vigo, Rocío Antolí Royo, Ana Cristina Gomila Grange, Aina Felipe Pérez, Nieves-C. Sanvisens Bergé, Arantza Antúnez Jorge, Emilia Fernández Rodríguez, Camino-M. Alvela-Suárez, Lucía Fidalgo Navarro, Alba Castro, Joaquín Polvorosa Gómez, María A. del Valle Sánchez, Mario Lopez Castro, José Chamorro Fernández, Antonio Javier Marcos Martín, Miguel |
| author_role |
author |
| author2 |
Herrera-Flores, Javier Rosón Hernández, Beatriz Medina García, José-A. Muga Bustamante, Roberto Fernández Solá, Joaquín Martín González, M. Candelaria Seco Hernández, Elena Suárez Cuervo, Carlos Mateos Díaz, Ana María Monte Secades, Rafael Machado Prieto, Begoña Puerta Louro, Rubén Prada González, Cristina Fernández Rial, Álvaro Sabio Repiso, Patricia Vázquez Vigo, Rocío Antolí Royo, Ana Cristina Gomila Grange, Aina Felipe Pérez, Nieves-C. Sanvisens Bergé, Arantza Antúnez Jorge, Emilia Fernández Rodríguez, Camino-M. Alvela-Suárez, Lucía Fidalgo Navarro, Alba Castro, Joaquín Polvorosa Gómez, María A. del Valle Sánchez, Mario Lopez Castro, José Chamorro Fernández, Antonio Javier Marcos Martín, Miguel |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Wernicke encephalopathy Alcoholic liver disease Alcohol use disorders Wernicke Encephalopathy 3205 Medicina Interna encefalopatía de Wernicke |
| topic |
Wernicke encephalopathy Alcoholic liver disease Alcohol use disorders Wernicke Encephalopathy 3205 Medicina Interna encefalopatía de Wernicke |
| description |
[EN] Background: data regarding the association between Wernicke encephalopathy (WE) and alcoholic liver disease (ALD) are scarce in spite of alcohol consumption being the main risk factor for WE. Aims: to describe the frequency of ALD in a cohort of patients diagnosed with WE and alcohol use disorders (AUDs) and to compare the characteristics of WE patients with and without ALD. Methods: we conducted an observational study in 21 centers through a nationwide registry of the Spanish Society of Internal Medicine. WE Caine criteria were applied and demographic, clinical, and outcome variables were analyzed. Results: 434 patients were included in the study, of which 372 were men (85.7%), and the mean age was 55 ± 11.8 years. ALD was present in 162 (37.3%) patients and we found a higher percentage of cases with tremor, flapping and hallucinations in the ALD group. A total of 22 patients (5.0%) died during admission (7.4% with ALD vs 3.7% without ALD; P = 0.087). Among the ALD patients, a relationship between mortality and the presence of anemia (Odds ratio [OR]=4.6 Confidence interval [CI]95% 1.1–18.8; P = 0.034), low level of consciousness (OR=4.9 CI95% 1.1–21.2; P = 0.031) and previous diagnosis of cancer (OR=10.3 CI95% 1.8–59.5; P = 0.009) was detected. Complete recovery was achieved by 27 patients with ALD (17.8%) and 71 (27.8%) without ALD (P = 0.030). Conclusion: the association of WE and ALD in patients with AUDs is frequent and potentially linked to differences in clinical presentation and to poorer prognosis, as compared to alcoholic patients with WE without ALD. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022 2024 2024 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
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publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/10366/159462 |
| url |
http://hdl.handle.net/10366/159462 |
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Inglés |
| language_invalid_str_mv |
Inglés |
| dc.rights.none.fl_str_mv |
Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ |
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openAccess |
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Elsevier |
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Elsevier |
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reponame:GREDOS. Repositorio Institucional de la Universidad de Salamanca instname:Universidad de Salamanca (USAL) |
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Universidad de Salamanca (USAL) |
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GREDOS. Repositorio Institucional de la Universidad de Salamanca |
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GREDOS. Repositorio Institucional de la Universidad de Salamanca |
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15.812429 |