Alcoholic Liver Disease Among Patients with Wernicke Encephalopathy

Background: data regarding the association between Wernicke encephalopathy (WE) and alcoholic liver disease (ALD) are scarce in spite of alcohol consumption being the main risk factor for WE. Aims: to describe the frequency of ALD in a cohort of patients diagnosed with WE and alcohol use disorders (...

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Detalles Bibliográficos
Autores: Novo-Veleiro, Ignacio|||0000-0003-0948-2440, Herrera Flores, Javier, Rosón-Hernández, Beatriz|||0000-0003-3568-2294, Medina-García, José-A., Muga, Roberto|||0000-0001-6301-431X, Fernández-Solá, Joaquim|||0000-0002-3218-0582, Martín-González, M., Seco-Hernández, Elena, Suárez-Cuervo, Carlos, Mateos-Díaz, Ana-M., Monte-Secades, Rafael|||0000-0003-4257-2712, Machado-Prieto, Begoña, Puerta-Louro, Rubén, Prada González, Cristina|||0000-0002-5780-0047, Fernández-Rial, Álvaro, Sabio Repiso, Patricia|||0000-0002-1878-8794, Vázquez-Vigo, Rocío, Antolí-Royo, Ana Cristina|||0000-0001-6273-9618, Gomila, Aina|||0000-0001-6979-9269, Felipe-Pérez, Nieves C, Sanvisens-Bergé, Arantza, Antúnez-Jorge, Emilia, Fernández-Rodríguez, Camino M., Alvela-Suárez, Lucia, Fidalgo-Navarro, Alba, Castro, Joaquín|||0000-0001-6248-3114, Polvorosa-Gómez, María A., Del Valle-Sánchez, Mario, López-Castro, José|||0000-0002-8402-3423, Chamorro, Antonio-J.|||0000-0002-2345-2873, Marcos, Miguel|||0000-0003-1269-4487
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:293955
Acceso en línea:https://ddd.uab.cat/record/293955
https://dx.doi.org/urn:doi:10.1016/j.drugalcdep.2021.109186
Access Level:acceso abierto
Palabra clave:Wernicke encephalopathy
Alcoholic liver disease
Alcohol use disorders
Descripción
Sumario:Background: data regarding the association between Wernicke encephalopathy (WE) and alcoholic liver disease (ALD) are scarce in spite of alcohol consumption being the main risk factor for WE. Aims: to describe the frequency of ALD in a cohort of patients diagnosed with WE and alcohol use disorders (AUDs) and to compare the characteristics of WE patients with and without ALD. Methods: we conducted an observational study in 21 centers through a nationwide registry of the Spanish Society of Internal Medicine. WE Caine criteria were applied and demographic, clinical, and outcome variables were analyzed. Results: 434 patients were included in the study, of which 372 were men (85.7%), and the mean age was 55 ± 11.8 years. ALD was present in 162 (37.3%) patients and we found a higher percentage of cases with tremor, flapping and hallucinations in the ALD group. A total of 22 patients (5.0%) died during admission (7.4% with ALD vs 3.7% without ALD; P = 0.087). Among the ALD patients, a relationship between mortality and the presence of anemia (Odds ratio [OR]=4.6 Confidence interval [CI]95% 1.1-18.8; P = 0.034), low level of consciousness (OR=4.9 CI95% 1.1-21.2; P = 0.031) and previous diagnosis of cancer (OR=10.3 CI95% 1.8-59.5; P = 0.009) was detected. Complete recovery was achieved by 27 patients with ALD (17.8%) and 71 (27.8%) without ALD (P = 0.030). Conclusion: the association of WE and ALD in patients with AUDs is frequent and potentially linked to differences in clinical presentation and to poorer prognosis, as compared to alcoholic patients with WE without ALD.

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