Differences between alcoholic and nonalcoholic patients with Wernicke encephalopathy: a multicenter observational study

[EN]Objective: To analyze the differences in characteristics and prognosis between alcoholic and nonalcoholic patients with Wernicke encephalopathy (WE). Patients and Methods: A retrospective observational cohort of 468 patients diagnosed with WE with at least 2 Caine criteria was selected from all...

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Detalles Bibliográficos
Autores: Chamorro Fernández, Antonio Javier, Rosón Hernández, Beatriz, Medina García, José-A., Muga Bustamante, Roberto, Fernández Solá, Joaquín, Martín González, M. Candelaria, Seco Hernández, Elena, Novo Veleiro, Ignacio, Suárez Cuervo, Carlos, Mateos Díaz, Ana M., Monte Secades, Rafael, Machado Prieto, Begoña, Puerta Louro, Rubén, Prada González, Cristina, Fernández Rial, Álvaro, Sabio Repiso, Patricia, Vázquez Vigo, Rocío, Antolí Royo, Ana Cristina, Gomila Grange, Aina, Felipe Pérez, Nieves-C., Sanvisens Bergé, Arantza, Antúnez Jorge, Emilia, Fernández Rodríguez, Camino-M., Alvela-Suárez, Lucía, Fidalgo Navarro, Alba, Marcos Martín, Miguel, Castro, Joaquín, Polvorosa Gómez, María A., del Valle Sánchez, Mario, Lopez Castro, José, González Quintela, Arturo, Laso Guzmán, Francisco Javier
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:España
Institución:Universidad de Salamanca (USAL)
Repositorio:GREDOS. Repositorio Institucional de la Universidad de Salamanca
OAI Identifier:oai:gredos.usal.es:10366/154080
Acceso en línea:http://hdl.handle.net/10366/154080
Access Level:acceso embargado
Palabra clave:Nonalcoholic patients
Alcoholic patients
Wernicke encephalopathy
Wernicke Encephalopathy
Alcoholics
6113.01 Alcoholismo
alcohólicos
encefalopatía de Wernicke
Descripción
Sumario:[EN]Objective: To analyze the differences in characteristics and prognosis between alcoholic and nonalcoholic patients with Wernicke encephalopathy (WE). Patients and Methods: A retrospective observational cohort of 468 patients diagnosed with WE with at least 2 Caine criteria was selected from all patients discharged with a diagnosis of WE from 21 medical centers in Spain from January 1, 2000, through December 31, 2012. Demographic, clinical, and outcome variables were described. Results: Among the 468 patients, the most common risk factor was alcoholism (n¼434 [92.7%]). More than one-third of patients (n¼181 [38.7%]) had the classic WE triad of symptoms (ocular signs, cerebellar dysfunction, and confusion). Among 252 patients for whom magnetic resonance imaging data were available, 135 (53.6%) had WE-related lesions and 42 (16.7%) had cerebellar lesions. Of the 468 patients, 25 (5.3%) died during hospitalization. Alcoholic patients presented more frequently than nonalcoholic patients with cerebellar signs (P¼.01) but less frequently with ocular signs (P¼.02). Alcoholic patients had a significantly higher frequency of hyponatremia (P¼.04) and decreased platelet count (P¼.005) compared with nonalcoholics. Alcoholic patients were diagnosed earlier than nonalcoholics (median time to diagnosis, 1 vs 4 days; P¼.001) and had shorter hospitalizations (13 vs 23 days; P¼.002). Conclusion: Compared with nonalcoholic patients, alcoholic patients with WE are more likely to present with cerebellar signs and less likely to have ocular signs. Diagnosis may be delayed in nonalcoholic patients. Mortality in the present series was lower than described previously.

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