Development of Geometry-Controlled All-Orthogonal BODIPY Trimers for Photodynamic Therapy and Phototheragnosis

We have established an easy synthetic protocol for selectively developing all-orthogonal BODIPY trimers with unprecedented geometries on the basis of selecting methyl oxidation versus electrophilic formylation of key dimeric precursors. Photophysical characterization together with biological assays...

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Detalhes bibliográficos
Autores: Prieto Castañeda, Alejandro, García Garrido, Fernando, Díaz Norambuena, Carolina, Escriche Navarro, Blanca, García Fernández, Alba, Bañuelos, Jorge, Rebollar, Esther, García Moreno, Inmaculada, Martínez Máñez, Ramón, Moya Cerero, Santiago de la, Rodríguez Agarrabeitia, Antonia, Ortiz García, María Josefa
Formato: artículo
Fecha de publicación:2022
País:España
Recursos:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/72062
Acesso em linha:https://hdl.handle.net/20.500.14352/72062
Access Level:acceso abierto
Palavra-chave:547
Química orgánica (Química)
2306 Química Orgánica
Descrição
Resumo:We have established an easy synthetic protocol for selectively developing all-orthogonal BODIPY trimers with unprecedented geometries on the basis of selecting methyl oxidation versus electrophilic formylation of key dimeric precursors. Photophysical characterization together with biological assays unraveled the most suitable BODIPY−BODIPY geometrical arrangements within the trimer, forcing them to serve as molecular platforms for the development of new, advanced heavy-atom-free photosensitizers for photodynamic therapy and phototheragnosis.

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