Development of Geometry-Controlled All-Orthogonal BODIPY Trimers for Photodynamic Therapy and Phototheragnosis

We have established an easy synthetic protocol for selectively developing all-orthogonal BODIPY trimers with unprece-dented geometries on the basis of selecting methyl oxidation versus electrophilic formylation of key dimeric precursors. Photophysical characterization together with biological assays...

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Detalles Bibliográficos
Autores: Prieto-Castaneda, A, Garcia-Garrido, F, Diaz-Norambuena, C, Escriche-Navarro, B, Garcia-Fernandez, A, Banuclos, J, Rebollar, E, Garcia-Moreno, I, Martinez-Manez, R, de la Moya, S, Agarrabeitia, AR, Ortiz, MJ
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Centro de Investigación Principe Felipe (CIPF)
Repositorio:r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
OAI Identifier:oai:cipf.fundanetsuite.com:p3947
Acceso en línea:https://cipf.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=3947
Access Level:acceso abierto
Descripción
Sumario:We have established an easy synthetic protocol for selectively developing all-orthogonal BODIPY trimers with unprece-dented geometries on the basis of selecting methyl oxidation versus electrophilic formylation of key dimeric precursors. Photophysical characterization together with biological assays unraveled the most suitable BODIPY-BODIPY geometrical arrangements within the trimer, forcing them to serve as molecular platforms for the development of new, advanced heavy-atom-free photosensitizers for photodynamic therapy and phototheragnosis.