Development of Geometry-Controlled All-Orthogonal BODIPY Trimers for Photodynamic Therapy and Phototheragnosis

We have established an easy synthetic protocol for selectively developing all-orthogonal BODIPY trimers with unprece-dented geometries on the basis of selecting methyl oxidation versus electrophilic formylation of key dimeric precursors. Photophysical characterization together with biological assays...

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Detalles Bibliográficos
Autores: Prieto Castañeda, Alejandro, García Garrido, Fernando, Díaz Norambuena, Carolina, Escriche Navarro, Blanca, García Fernández, Alba, Bañuelos Prieto, Jorge, Rebollar, Esther, García Moreno, Inmaculada, Martínez Máñez, Ramón, de la Moya, Santiago, Agarrabeitia, Antonia R., Ortiz, María J.
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universidad del País Vasco
Repositorio:Addi. Archivo Digital para la Docencia y la Investigación
OAI Identifier:oai:addi.ehu.eus:10810/57419
Acceso en línea:http://hdl.handle.net/10810/57419
Access Level:acceso abierto
Palabra clave:rational design
photosensitizers
dimers
Descripción
Sumario:We have established an easy synthetic protocol for selectively developing all-orthogonal BODIPY trimers with unprece-dented geometries on the basis of selecting methyl oxidation versus electrophilic formylation of key dimeric precursors. Photophysical characterization together with biological assays unraveled the most suitable BODIPY-BODIPY geometrical arrangements within the trimer, forcing them to serve as molecular platforms for the development of new, advanced heavy-atom-free photosensitizers for photodynamic therapy and phototheragnosis.

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