From nanometric to giant polyion complex micelles via a hierarchical assembly of dendrimers

PIC (polyion complex) micelles prepared from oppositely charged block copolymers have typical diameters of about 30-50 nm. Attempts to control their size have proven elusive. Since the presence of a neutral hydrophilic block in the copolymers, such as poly(ethylene glycol) (PEG), allows confining th...

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Detalles Bibliográficos
Autores: Lopez-Blanco, Roi, Magana Rodriguez, Jose Rodrigo, Esquena, Jordi, Fernandez-Megia, Eduardo
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2025
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/382099
Acceso en línea:http://hdl.handle.net/10261/382099
https://api.elsevier.com/content/abstract/scopus_id/85217824321
Access Level:acceso embargado
Palabra clave:Polyion complex
Dendrimer
Giant micelle
Hierarchical assembly
PIC
http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
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spelling From nanometric to giant polyion complex micelles via a hierarchical assembly of dendrimersLopez-Blanco, RoiMagana Rodriguez, Jose RodrigoEsquena, JordiFernandez-Megia, EduardoPolyion complexDendrimerGiant micelleHierarchical assemblyPIChttp://metadata.un.org/sdg/3Ensure healthy lives and promote well-being for all at all agesPIC (polyion complex) micelles prepared from oppositely charged block copolymers have typical diameters of about 30-50 nm. Attempts to control their size have proven elusive. Since the presence of a neutral hydrophilic block in the copolymers, such as poly(ethylene glycol) (PEG), allows confining the charged blocks within a core, reducing PEGylation was expected to produce larger micelles to accommodate fewer/smaller PEG chains at the corona.This work was supported by grant PID2021-127684OB-I00 funded by MCIN/AEI/ 10.13039/501100011033 and by “ERDF A way of making Europe”. The authors also thank the financial support from Xunta de Galicia (ED431C 2022/21, and Centro de Investigación do Sistema Universitario de Galicia accreditation 2023-2027, ED431G 2023/03) and the European Union (European Regional Development Fund - ERDF). The authors are grateful to Carlos Fernández Pereira for helpful discussions about the fitting of PIC size data to Eq. (1) and the development of Eqs. (3), (5), and (7). The authors also thank Dr. Adriana L. Rojas and Isaac Santos-Pérez for cryo-TEM data collection at the EM Platform of CIC bioGUNE (Bilbao, Spain). J. R. M. acknowledges the European Union’s Horizon 2020 research and innovation program under Marie Sklodwska-Curie grant agreement (No. 801342, Tecniospring INDUSTRY) and the Government of Catalonia’s Agency for Business Competitiveness (ACCIO).Peer reviewedElsevierEuropean CommissionMinisterio de Ciencia e Innovación (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202520252025info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionhttp://hdl.handle.net/10261/382099https://api.elsevier.com/content/abstract/scopus_id/85217824321reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/EC/H2020/801342info:eu-repo/grantAgreement/MCIN/AEI/ 10.13039Journal of colloid and interface scienceSíinfo:eu-repo/semantics/embargoedAccessoai:digital.csic.es:10261/3820992026-05-22T06:33:51Z
dc.title.none.fl_str_mv From nanometric to giant polyion complex micelles via a hierarchical assembly of dendrimers
title From nanometric to giant polyion complex micelles via a hierarchical assembly of dendrimers
spellingShingle From nanometric to giant polyion complex micelles via a hierarchical assembly of dendrimers
Lopez-Blanco, Roi
Polyion complex
Dendrimer
Giant micelle
Hierarchical assembly
PIC
http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
title_short From nanometric to giant polyion complex micelles via a hierarchical assembly of dendrimers
title_full From nanometric to giant polyion complex micelles via a hierarchical assembly of dendrimers
title_fullStr From nanometric to giant polyion complex micelles via a hierarchical assembly of dendrimers
title_full_unstemmed From nanometric to giant polyion complex micelles via a hierarchical assembly of dendrimers
title_sort From nanometric to giant polyion complex micelles via a hierarchical assembly of dendrimers
dc.creator.none.fl_str_mv Lopez-Blanco, Roi
Magana Rodriguez, Jose Rodrigo
Esquena, Jordi
Fernandez-Megia, Eduardo
author Lopez-Blanco, Roi
author_facet Lopez-Blanco, Roi
Magana Rodriguez, Jose Rodrigo
Esquena, Jordi
Fernandez-Megia, Eduardo
author_role author
author2 Magana Rodriguez, Jose Rodrigo
Esquena, Jordi
Fernandez-Megia, Eduardo
author2_role author
author
author
dc.contributor.none.fl_str_mv European Commission
Ministerio de Ciencia e Innovación (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Polyion complex
Dendrimer
Giant micelle
Hierarchical assembly
PIC
http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
topic Polyion complex
Dendrimer
Giant micelle
Hierarchical assembly
PIC
http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
description PIC (polyion complex) micelles prepared from oppositely charged block copolymers have typical diameters of about 30-50 nm. Attempts to control their size have proven elusive. Since the presence of a neutral hydrophilic block in the copolymers, such as poly(ethylene glycol) (PEG), allows confining the charged blocks within a core, reducing PEGylation was expected to produce larger micelles to accommodate fewer/smaller PEG chains at the corona.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/382099
https://api.elsevier.com/content/abstract/scopus_id/85217824321
url http://hdl.handle.net/10261/382099
https://api.elsevier.com/content/abstract/scopus_id/85217824321
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/EC/H2020/801342
info:eu-repo/grantAgreement/MCIN/AEI/ 10.13039
Journal of colloid and interface science
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/embargoedAccess
eu_rights_str_mv embargoedAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
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