From nanometric to giant polyion complex micelles via a hierarchical assembly of dendrimers

PIC (polyion complex) micelles prepared from oppositely charged block copolymers have typical diameters of about 30-50 nm. Attempts to control their size have proven elusive. Since the presence of a neutral hydrophilic block in the copolymers, such as poly(ethylene glycol) (PEG), allows confining th...

Descripción completa

Detalles Bibliográficos
Autores: Lopez-Blanco, Roi, Magana Rodriguez, Jose Rodrigo, Esquena, Jordi, Fernandez-Megia, Eduardo
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2025
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/382099
Acceso en línea:http://hdl.handle.net/10261/382099
https://api.elsevier.com/content/abstract/scopus_id/85217824321
Access Level:acceso embargado
Palabra clave:Polyion complex
Dendrimer
Giant micelle
Hierarchical assembly
PIC
http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
Descripción
Sumario:PIC (polyion complex) micelles prepared from oppositely charged block copolymers have typical diameters of about 30-50 nm. Attempts to control their size have proven elusive. Since the presence of a neutral hydrophilic block in the copolymers, such as poly(ethylene glycol) (PEG), allows confining the charged blocks within a core, reducing PEGylation was expected to produce larger micelles to accommodate fewer/smaller PEG chains at the corona.