Reduced Plasma Orexin-A Concentrations are Associated with Cognitive Deficits in Anorexia Nervosa.

Orexins/hypocretins are neuropeptides implicated in numerous processes, including food intake and cognition. The role of these peptides in the psychopathology of anorexia nervosa (AN) remains poorly understood. The aim of the current study was to evaluate the associations between plasma orexin-A (OX...

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Autores: Steward, Trevor, Mestre-Bach, Gemma, Granero, Roser, Sánchez, Isabel, Riesco, Nadine, Vintró-Alcaraz, Cristina, Sauchelli, Sarah, Jiménez-Murcia, Susana, Agüera, Zaida, Fernández-García, José Carlos, Garrido-Sánchez, Lourdes, Tinahones, Francisco J, Casanueva, Felipe F, Baños, Rosa M, Botella, Cristina, Crujeiras, Ana B, Torre, Rafael de la, Fernández-Real, Jose M, Frühbeck, Gema, Ortega, Francisco J, Rodríguez, Amaia, Menchón, José M, Fernández-Aranda, Fernando
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/17868
Acceso en línea:http://hdl.handle.net/20.500.12105/17868
Access Level:acceso abierto
Palabra clave:Adult
Anorexia Nervosa
Case-Control Studies
Cognitive Dysfunction
Decision Making
Female
Humans
Orexins
Wisconsin Card Sorting Test
Young Adult
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repository_id_str
spelling Reduced Plasma Orexin-A Concentrations are Associated with Cognitive Deficits in Anorexia Nervosa.Steward, TrevorMestre-Bach, GemmaGranero, RoserSánchez, IsabelRiesco, NadineVintró-Alcaraz, CristinaSauchelli, SarahJiménez-Murcia, SusanaAgüera, ZaidaFernández-García, José CarlosGarrido-Sánchez, LourdesTinahones, Francisco JCasanueva, Felipe FBaños, Rosa MBotella, CristinaCrujeiras, Ana BTorre, Rafael de laFernández-Real, Jose MFrühbeck, GemaOrtega, Francisco JRodríguez, AmaiaMenchón, José MFernández-Aranda, FernandoAdultAnorexia NervosaCase-Control StudiesCognitive DysfunctionDecision MakingFemaleHumansOrexinsWisconsin Card Sorting TestYoung AdultOrexins/hypocretins are neuropeptides implicated in numerous processes, including food intake and cognition. The role of these peptides in the psychopathology of anorexia nervosa (AN) remains poorly understood. The aim of the current study was to evaluate the associations between plasma orexin-A (OXA) concentrations and neuropsychological functioning in adult women with AN, and a matched control group. Fasting plasma OXA concentrations were taken in 51 females with AN and in 51 matched healthy controls. Set-shifting was assessed using the Wisconsin Card Sorting Test (WCST), whereas decision making was measured using the Iowa Gambling Task (IGT). The AN group exhibited lower plasma OXA levels than the HC group. Lower mean scores were obtained on the IGT in AN patients. WCST perseverative errors were significantly higher in the AN group compared to HC. In both the AN and HC group, OXA levels were negatively correlated with WCST non-perseverative errors. Reduced plasma OXA concentrations were found to be associated with set-shifting impairments in AN. Taking into consideration the function of orexins in promoting arousal and cognitive flexibility, future studies should explore whether orexin partly underpins the cognitive impairments found in AN.20242024-02-1020192019-05-2720192019-05-27research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articlehttp://hdl.handle.net/20.500.12105/17868reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/178682026-06-12T12:43:37Z
dc.title.none.fl_str_mv Reduced Plasma Orexin-A Concentrations are Associated with Cognitive Deficits in Anorexia Nervosa.
title Reduced Plasma Orexin-A Concentrations are Associated with Cognitive Deficits in Anorexia Nervosa.
spellingShingle Reduced Plasma Orexin-A Concentrations are Associated with Cognitive Deficits in Anorexia Nervosa.
Steward, Trevor
Adult
Anorexia Nervosa
Case-Control Studies
Cognitive Dysfunction
Decision Making
Female
Humans
Orexins
Wisconsin Card Sorting Test
Young Adult
title_short Reduced Plasma Orexin-A Concentrations are Associated with Cognitive Deficits in Anorexia Nervosa.
title_full Reduced Plasma Orexin-A Concentrations are Associated with Cognitive Deficits in Anorexia Nervosa.
title_fullStr Reduced Plasma Orexin-A Concentrations are Associated with Cognitive Deficits in Anorexia Nervosa.
title_full_unstemmed Reduced Plasma Orexin-A Concentrations are Associated with Cognitive Deficits in Anorexia Nervosa.
title_sort Reduced Plasma Orexin-A Concentrations are Associated with Cognitive Deficits in Anorexia Nervosa.
dc.creator.none.fl_str_mv Steward, Trevor
Mestre-Bach, Gemma
Granero, Roser
Sánchez, Isabel
Riesco, Nadine
Vintró-Alcaraz, Cristina
Sauchelli, Sarah
Jiménez-Murcia, Susana
Agüera, Zaida
Fernández-García, José Carlos
Garrido-Sánchez, Lourdes
Tinahones, Francisco J
Casanueva, Felipe F
Baños, Rosa M
Botella, Cristina
Crujeiras, Ana B
Torre, Rafael de la
Fernández-Real, Jose M
Frühbeck, Gema
Ortega, Francisco J
Rodríguez, Amaia
Menchón, José M
Fernández-Aranda, Fernando
author Steward, Trevor
author_facet Steward, Trevor
Mestre-Bach, Gemma
Granero, Roser
Sánchez, Isabel
Riesco, Nadine
Vintró-Alcaraz, Cristina
Sauchelli, Sarah
Jiménez-Murcia, Susana
Agüera, Zaida
Fernández-García, José Carlos
Garrido-Sánchez, Lourdes
Tinahones, Francisco J
Casanueva, Felipe F
Baños, Rosa M
Botella, Cristina
Crujeiras, Ana B
Torre, Rafael de la
Fernández-Real, Jose M
Frühbeck, Gema
Ortega, Francisco J
Rodríguez, Amaia
Menchón, José M
Fernández-Aranda, Fernando
author_role author
author2 Mestre-Bach, Gemma
Granero, Roser
Sánchez, Isabel
Riesco, Nadine
Vintró-Alcaraz, Cristina
Sauchelli, Sarah
Jiménez-Murcia, Susana
Agüera, Zaida
Fernández-García, José Carlos
Garrido-Sánchez, Lourdes
Tinahones, Francisco J
Casanueva, Felipe F
Baños, Rosa M
Botella, Cristina
Crujeiras, Ana B
Torre, Rafael de la
Fernández-Real, Jose M
Frühbeck, Gema
Ortega, Francisco J
Rodríguez, Amaia
Menchón, José M
Fernández-Aranda, Fernando
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Adult
Anorexia Nervosa
Case-Control Studies
Cognitive Dysfunction
Decision Making
Female
Humans
Orexins
Wisconsin Card Sorting Test
Young Adult
topic Adult
Anorexia Nervosa
Case-Control Studies
Cognitive Dysfunction
Decision Making
Female
Humans
Orexins
Wisconsin Card Sorting Test
Young Adult
description Orexins/hypocretins are neuropeptides implicated in numerous processes, including food intake and cognition. The role of these peptides in the psychopathology of anorexia nervosa (AN) remains poorly understood. The aim of the current study was to evaluate the associations between plasma orexin-A (OXA) concentrations and neuropsychological functioning in adult women with AN, and a matched control group. Fasting plasma OXA concentrations were taken in 51 females with AN and in 51 matched healthy controls. Set-shifting was assessed using the Wisconsin Card Sorting Test (WCST), whereas decision making was measured using the Iowa Gambling Task (IGT). The AN group exhibited lower plasma OXA levels than the HC group. Lower mean scores were obtained on the IGT in AN patients. WCST perseverative errors were significantly higher in the AN group compared to HC. In both the AN and HC group, OXA levels were negatively correlated with WCST non-perseverative errors. Reduced plasma OXA concentrations were found to be associated with set-shifting impairments in AN. Taking into consideration the function of orexins in promoting arousal and cognitive flexibility, future studies should explore whether orexin partly underpins the cognitive impairments found in AN.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-05-27
2019
2019-05-27
2024
2024-02-10
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12105/17868
url http://hdl.handle.net/20.500.12105/17868
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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