Orexin and sleep quality in anorexia nervosa

Background and aims: Orexins/hypocretins are orexigenic peptides implicated in the regulation of feedingbehavior and the sleep/wake cycle. Little is known about the functioning of these peptides in anorexianervosa (AN). The aims of the current study were to evaluate the extent to which orexin-A migh...

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Detalles Bibliográficos
Autores: Sauchelli, Sarah|||0000-0003-3620-7671, Jiménez Murcia, Susana|||0000-0002-3596-8033, Sánchez Díaz, Isabel María|||0000-0001-5874-8204, Riesco, Nadine|||0000-0002-6336-4907, Custal, Núria, Fernández-García, José C.|||0000-0003-2229-8488, Garrido Sánchez, Lourdes|||0000-0003-0756-9606, Tinahones, Francisco J.|||0000-0001-6871-4403, Steiger, Howard|||0000-0003-4887-7824, Israel, Mimi|||0000-0003-0962-3514, Baños, Rosa|||0000-0003-0626-7665, Botella, Cristina|||0000-0001-8783-6959, Torre, Rafael de la|||0000-0002-6765-1866, Fernández-Real Lemos, José Manuel|||0000-0002-7442-9323, Ortega, Francisco|||0000-0003-0039-1593, Frühbeck, Gema|||0000-0002-8305-7154, Granero, Roser|||0000-0001-6308-3198, Tárrega Larrea, Salomé|||0000-0002-5820-6795, Crujeiras, Ana B.|||0000-0003-4392-0301, Rodríguez, Amaia|||0000-0002-2180-461X, Estivill, Xavier|||0000-0002-0723-2256, Beckmann, Jacques S.|||0000-0002-9741-1900, Casanueva, Felipe F.|||0000-0002-9052-8161, Menchón Magriñá, José Manuel|||0000-0002-6231-6524, Fernández Aranda, Fernando|||0000-0002-2968-9898
Tipo de recurso: artículo
Fecha de publicación:2016
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:319894
Acceso en línea:https://ddd.uab.cat/record/319894
https://dx.doi.org/urn:doi:10.1016/j.psyneuen.2015.12.014
Access Level:acceso abierto
Palabra clave:Anorexia nervosa
Orexin-A
Partial hospitalization
Sleep
Treatment outcome
Descripción
Sumario:Background and aims: Orexins/hypocretins are orexigenic peptides implicated in the regulation of feedingbehavior and the sleep/wake cycle. Little is known about the functioning of these peptides in anorexianervosa (AN). The aims of the current study were to evaluate the extent to which orexin-A might belinked to sleep and treatment outcome in AN.Method: Fasting plasma orexin-A concentrations were measured in 48 females with AN at the start of a dayhospital treatment and in 98 normaleater/healthy-weight controls. The Pittsburgh Sleep Quality Indexwas administered at the beginning of the treatment as a measure of sleep quality. Other psychopatho-logical variables were evaluated with the Symptom Checklist-Revised (SCL90R) and the Eating DisorderInventory-2 (EDI). Patients were assessed at the start and end of treatment by means of commonly useddiagnostic criteria and clinical questionnaires.Results: The AN patients presented more sleep disturbances and poorer overall sleep quality than didthe healthy controls (p = .026) but there were no global differences between groups in plasma orexin-Aconcentrations (p = .071). In the AN sample, orexin-A concentrations were associated with greater sleepdisturbances (|r| = .30), sleep inefficiency (|r| = .22) and poorer overall sleep (|r| = .22). Structural EquationModeling (SEM) showed that both elevated orexin-A concentrations and inadequate sleep predictedpoorer treatment outcome.contribute to poor sleep quality in AN, and both of these variables are associated with therapy response.

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