Reduced Plasma Orexin-A Concentrations are Associated with Cognitive Deficits in Anorexia Nervosa.

Orexins/hypocretins are neuropeptides implicated in numerous processes, including food intake and cognition. The role of these peptides in the psychopathology of anorexia nervosa (AN) remains poorly understood. The aim of the current study was to evaluate the associations between plasma orexin-A (OX...

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Detalles Bibliográficos
Autores: Steward, Trevor, Mestre-Bach, Gemma, Granero, Roser, Sánchez, Isabel, Riesco, Nadine, Vintró-Alcaraz, Cristina, Sauchelli, Sarah, Jiménez-Murcia, Susana, Agüera, Zaida, Fernández-García, José Carlos, Garrido-Sánchez, Lourdes, Tinahones, Francisco J, Casanueva, Felipe F, Baños, Rosa M, Botella, Cristina, Crujeiras, Ana B, Torre, Rafael de la, Fernández-Real, Jose M, Frühbeck, Gema, Ortega, Francisco J, Rodríguez, Amaia, Menchón, José M, Fernández-Aranda, Fernando
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/17868
Acceso en línea:http://hdl.handle.net/20.500.12105/17868
Access Level:acceso abierto
Palabra clave:Adult
Anorexia Nervosa
Case-Control Studies
Cognitive Dysfunction
Decision Making
Female
Humans
Orexins
Wisconsin Card Sorting Test
Young Adult
Descripción
Sumario:Orexins/hypocretins are neuropeptides implicated in numerous processes, including food intake and cognition. The role of these peptides in the psychopathology of anorexia nervosa (AN) remains poorly understood. The aim of the current study was to evaluate the associations between plasma orexin-A (OXA) concentrations and neuropsychological functioning in adult women with AN, and a matched control group. Fasting plasma OXA concentrations were taken in 51 females with AN and in 51 matched healthy controls. Set-shifting was assessed using the Wisconsin Card Sorting Test (WCST), whereas decision making was measured using the Iowa Gambling Task (IGT). The AN group exhibited lower plasma OXA levels than the HC group. Lower mean scores were obtained on the IGT in AN patients. WCST perseverative errors were significantly higher in the AN group compared to HC. In both the AN and HC group, OXA levels were negatively correlated with WCST non-perseverative errors. Reduced plasma OXA concentrations were found to be associated with set-shifting impairments in AN. Taking into consideration the function of orexins in promoting arousal and cognitive flexibility, future studies should explore whether orexin partly underpins the cognitive impairments found in AN.

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