Detecting disability using self-reported and clinical assessments in early-stage relapsing-remitting multiple sclerosis: Looking for a complementary approach

Disability accrual is mainly driven by progression independent of relapse activity, which is present even in early stages of relapsing-remitting multiple sclerosis (RRMS) and sometimes overlooked. This multicenter, non-interventional study evaluated whether patient-reported outcomes measures (PROMs)...

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Detalhes bibliográficos
Autores: de la Maza, SS, Gomez-Ballesteros, R, Borges, M, Martin-Martinez, J, Sotoca, J, Alonso, A, Caminero, AB, Borrega, L, Sanchez-Menoyo, JL, Barrero-Hernandez, FJ, Calles, C, Brieva, L, Blasco-Quilez, MR, Garcia-Soto, JD, del Campo-Amigo, M, Navarro-Canto, L, Aguera, E, Garces-Redondo, M, Carmona, O, Gabaldon-Torres, L, Forero, L, Hervas, M, Medrano, N, Maurino, J, Castillo-Trivino, T
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Recursos:Institut d'Investigació i Innovació Parc Taulí (I3PT)
Repositorio:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
OAI Identifier:oai:i3pt.fundanetsuite.com:p3285
Acesso em linha:https://i3pt.portalinvestigacion.com/publicaciones/3285
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85159056004&doi=10.1177%2f20552173231169475&partnerID=40&md5=03c0646599c713a80333beb89a22413e
Access Level:acceso abierto
Palavra-chave:Relapsing-remitting multiple sclerosis
patient-reported outcomes
early-stage
disability progression
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spelling Detecting disability using self-reported and clinical assessments in early-stage relapsing-remitting multiple sclerosis: Looking for a complementary approachde la Maza, SSGomez-Ballesteros, RBorges, MMartin-Martinez, JSotoca, JAlonso, ACaminero, ABBorrega, LSanchez-Menoyo, JLBarrero-Hernandez, FJCalles, CBrieva, LBlasco-Quilez, MRGarcia-Soto, JDdel Campo-Amigo, MNavarro-Canto, LAguera, EGarces-Redondo, MCarmona, OGabaldon-Torres, LForero, LHervas, MMedrano, NMaurino, JCastillo-Trivino, TRelapsing-remitting multiple sclerosispatient-reported outcomesearly-stagedisability progressionDisability accrual is mainly driven by progression independent of relapse activity, which is present even in early stages of relapsing-remitting multiple sclerosis (RRMS) and sometimes overlooked. This multicenter, non-interventional study evaluated whether patient-reported outcomes measures (PROMs) could capture disability in 189 early-stage RRMS patients (mean age: 36.1 +/- 9.4 years, 71.4% female, mean disease duration: 1.4 +/- 0.8 years, median EDSS: 1.0). The 9-Hole Peg Test (9-HPT), NeuroQoL Upper Extremity (NeuroQoL-UE), Timed 25-Foot Walk (T25-FW), Multiple Sclerosis Walking Scale (MSWS-12), Symbol Digit Modalities Test (SDMT), and Perceived Deficits Questionnaire (PDQ-5) were used to assess hand function, gait, and cognition, respectively. These functions were at least mildly affected in this early-stage population, finding significant correlations between PROMs and clinical assessments. PROMs could enable early-stage RRMS patients to communicate their perceived disability in different domains, assisting clinicians in disease monitoring and decision making.SAGE PUBLICATIONS INC2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://i3pt.portalinvestigacion.com/publicaciones/3285https://www.scopus.com/inward/record.uri?eid=2-s2.0-85159056004&doi=10.1177%2f20552173231169475&partnerID=40&md5=03c0646599c713a80333beb89a22413eMultiple Sclerosis Journal-Experimental Translational and ClinicalISSN: 20552173reponame:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulíinstname:Institut d'Investigació i Innovació Parc Taulí (I3PT)Inglésinfo:eu-repo/semantics/openAccessoai:i3pt.fundanetsuite.com:p32852026-06-21T15:30:37Z
dc.title.none.fl_str_mv Detecting disability using self-reported and clinical assessments in early-stage relapsing-remitting multiple sclerosis: Looking for a complementary approach
title Detecting disability using self-reported and clinical assessments in early-stage relapsing-remitting multiple sclerosis: Looking for a complementary approach
spellingShingle Detecting disability using self-reported and clinical assessments in early-stage relapsing-remitting multiple sclerosis: Looking for a complementary approach
de la Maza, SS
Relapsing-remitting multiple sclerosis
patient-reported outcomes
early-stage
disability progression
title_short Detecting disability using self-reported and clinical assessments in early-stage relapsing-remitting multiple sclerosis: Looking for a complementary approach
title_full Detecting disability using self-reported and clinical assessments in early-stage relapsing-remitting multiple sclerosis: Looking for a complementary approach
title_fullStr Detecting disability using self-reported and clinical assessments in early-stage relapsing-remitting multiple sclerosis: Looking for a complementary approach
title_full_unstemmed Detecting disability using self-reported and clinical assessments in early-stage relapsing-remitting multiple sclerosis: Looking for a complementary approach
title_sort Detecting disability using self-reported and clinical assessments in early-stage relapsing-remitting multiple sclerosis: Looking for a complementary approach
dc.creator.none.fl_str_mv de la Maza, SS
Gomez-Ballesteros, R
Borges, M
Martin-Martinez, J
Sotoca, J
Alonso, A
Caminero, AB
Borrega, L
Sanchez-Menoyo, JL
Barrero-Hernandez, FJ
Calles, C
Brieva, L
Blasco-Quilez, MR
Garcia-Soto, JD
del Campo-Amigo, M
Navarro-Canto, L
Aguera, E
Garces-Redondo, M
Carmona, O
Gabaldon-Torres, L
Forero, L
Hervas, M
Medrano, N
Maurino, J
Castillo-Trivino, T
author de la Maza, SS
author_facet de la Maza, SS
Gomez-Ballesteros, R
Borges, M
Martin-Martinez, J
Sotoca, J
Alonso, A
Caminero, AB
Borrega, L
Sanchez-Menoyo, JL
Barrero-Hernandez, FJ
Calles, C
Brieva, L
Blasco-Quilez, MR
Garcia-Soto, JD
del Campo-Amigo, M
Navarro-Canto, L
Aguera, E
Garces-Redondo, M
Carmona, O
Gabaldon-Torres, L
Forero, L
Hervas, M
Medrano, N
Maurino, J
Castillo-Trivino, T
author_role author
author2 Gomez-Ballesteros, R
Borges, M
Martin-Martinez, J
Sotoca, J
Alonso, A
Caminero, AB
Borrega, L
Sanchez-Menoyo, JL
Barrero-Hernandez, FJ
Calles, C
Brieva, L
Blasco-Quilez, MR
Garcia-Soto, JD
del Campo-Amigo, M
Navarro-Canto, L
Aguera, E
Garces-Redondo, M
Carmona, O
Gabaldon-Torres, L
Forero, L
Hervas, M
Medrano, N
Maurino, J
Castillo-Trivino, T
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Relapsing-remitting multiple sclerosis
patient-reported outcomes
early-stage
disability progression
topic Relapsing-remitting multiple sclerosis
patient-reported outcomes
early-stage
disability progression
description Disability accrual is mainly driven by progression independent of relapse activity, which is present even in early stages of relapsing-remitting multiple sclerosis (RRMS) and sometimes overlooked. This multicenter, non-interventional study evaluated whether patient-reported outcomes measures (PROMs) could capture disability in 189 early-stage RRMS patients (mean age: 36.1 +/- 9.4 years, 71.4% female, mean disease duration: 1.4 +/- 0.8 years, median EDSS: 1.0). The 9-Hole Peg Test (9-HPT), NeuroQoL Upper Extremity (NeuroQoL-UE), Timed 25-Foot Walk (T25-FW), Multiple Sclerosis Walking Scale (MSWS-12), Symbol Digit Modalities Test (SDMT), and Perceived Deficits Questionnaire (PDQ-5) were used to assess hand function, gait, and cognition, respectively. These functions were at least mildly affected in this early-stage population, finding significant correlations between PROMs and clinical assessments. PROMs could enable early-stage RRMS patients to communicate their perceived disability in different domains, assisting clinicians in disease monitoring and decision making.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://i3pt.portalinvestigacion.com/publicaciones/3285
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85159056004&doi=10.1177%2f20552173231169475&partnerID=40&md5=03c0646599c713a80333beb89a22413e
url https://i3pt.portalinvestigacion.com/publicaciones/3285
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85159056004&doi=10.1177%2f20552173231169475&partnerID=40&md5=03c0646599c713a80333beb89a22413e
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv SAGE PUBLICATIONS INC
publisher.none.fl_str_mv SAGE PUBLICATIONS INC
dc.source.none.fl_str_mv Multiple Sclerosis Journal-Experimental Translational and Clinical
ISSN: 20552173
reponame:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
instname:Institut d'Investigació i Innovació Parc Taulí (I3PT)
instname_str Institut d'Investigació i Innovació Parc Taulí (I3PT)
reponame_str r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
collection r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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