Detecting disability using self-reported and clinical assessments in early-stage relapsing-remitting multiple sclerosis: Looking for a complementary approach

Disability accrual is mainly driven by progression independent of relapse activity, which is present even in early stages of relapsing-remitting multiple sclerosis (RRMS) and sometimes overlooked. This multicenter, non-interventional study evaluated whether patient-reported outcomes measures (PROMs)...

Descripción completa

Detalles Bibliográficos
Autores: de la Maza, SS, Gomez-Ballesteros, R, Borges, M, Martin-Martinez, J, Sotoca, J, Alonso, A, Caminero, AB, Borrega, L, Sanchez-Menoyo, JL, Barrero-Hernandez, FJ, Calles, C, Brieva, L, Blasco-Quilez, MR, Garcia-Soto, JD, del Campo-Amigo, M, Navarro-Canto, L, Aguera, E, Garces-Redondo, M, Carmona, O, Gabaldon-Torres, L, Forero, L, Hervas, M, Medrano, N, Maurino, J, Castillo-Trivino, T
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Institut d'Investigació i Innovació Parc Taulí (I3PT)
Repositorio:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
OAI Identifier:oai:i3pt.fundanetsuite.com:p3285
Acceso en línea:https://i3pt.portalinvestigacion.com/publicaciones/3285
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85159056004&doi=10.1177%2f20552173231169475&partnerID=40&md5=03c0646599c713a80333beb89a22413e
Access Level:acceso abierto
Palabra clave:Relapsing-remitting multiple sclerosis
patient-reported outcomes
early-stage
disability progression
Descripción
Sumario:Disability accrual is mainly driven by progression independent of relapse activity, which is present even in early stages of relapsing-remitting multiple sclerosis (RRMS) and sometimes overlooked. This multicenter, non-interventional study evaluated whether patient-reported outcomes measures (PROMs) could capture disability in 189 early-stage RRMS patients (mean age: 36.1 +/- 9.4 years, 71.4% female, mean disease duration: 1.4 +/- 0.8 years, median EDSS: 1.0). The 9-Hole Peg Test (9-HPT), NeuroQoL Upper Extremity (NeuroQoL-UE), Timed 25-Foot Walk (T25-FW), Multiple Sclerosis Walking Scale (MSWS-12), Symbol Digit Modalities Test (SDMT), and Perceived Deficits Questionnaire (PDQ-5) were used to assess hand function, gait, and cognition, respectively. These functions were at least mildly affected in this early-stage population, finding significant correlations between PROMs and clinical assessments. PROMs could enable early-stage RRMS patients to communicate their perceived disability in different domains, assisting clinicians in disease monitoring and decision making.

Similares en LA Referencia