Detecting disability using self-reported and clinical assessments in early-stage relapsing-remitting multiple sclerosis: Looking for a complementary approach

Disability accrual is mainly driven by progression independent of relapse activity, which is present even in early stages of relapsing-remitting multiple sclerosis (RRMS) and sometimes overlooked. This multicenter, non-interventional study evaluated whether patient-reported outcomes measures (PROMs)...

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Detalhes bibliográficos
Autores: Sainz de la Maza, Susana, Gómez-Ballesteros, Rocío, Borges, Mónica, Martín-Martínez, Jesús, Sotoca, Javier, Alonso, Ana, Caminero, Ana B., Borrega, Laura, Sánchez-Menoyo, José L, Barrero Hernández, Francisco Javier, Calles-Hernandez, M. Carmen, Brieva, Luis, Blasco-Quílez, María R, Dotor García-Soto, Julio, Del Campo-Amigo, María, Navarro-Cantó, Laura, Agüera, Eduardo, Garcés-Redondo, Moisés, Carmona, Olga, Gabaldón-Torres, Laura, Forero, Lucía, Hervàs, Mariona, Medrano, Nicolás, Maurino, Jorge, Castillo-Triviño, Tamara
Formato: artículo
Fecha de publicación:2023
País:España
Recursos:Conselleria de Salut i Consum del Govern de les Illes Balears
Repositorio:Docusalut
Idioma:inglés
OAI Identifier:oai:docusalut.com:20.500.13003/25434
Acesso em linha:https://hdl.handle.net/20.500.13003/25434
Access Level:acceso abierto
Palavra-chave:Multiple Sclerosis, Relapsing-Remitting
Patient Reported Outcome Measures
Esclerosis Múltiple Recurrente-Remitente
Medición de Resultados Informados por el Paciente
Relapsing-remitting multiple sclerosis
disability progression
early-stage
patient-reported outcomes
Descrição
Resumo:Disability accrual is mainly driven by progression independent of relapse activity, which is present even in early stages of relapsing-remitting multiple sclerosis (RRMS) and sometimes overlooked. This multicenter, non-interventional study evaluated whether patient-reported outcomes measures (PROMs) could capture disability in 189 early-stage RRMS patients (mean age: 36.1 ± 9.4 years, 71.4% female, mean disease duration: 1.4 ± 0.8 years, median EDSS: 1.0). The 9-Hole Peg Test (9-HPT), NeuroQoL Upper Extremity (NeuroQoL-UE), Timed 25-Foot Walk (T25-FW), Multiple Sclerosis Walking Scale (MSWS-12), Symbol Digit Modalities Test (SDMT), and Perceived Deficits Questionnaire (PDQ-5) were used to assess hand function, gait, and cognition, respectively. These functions were at least mildly affected in this early-stage population, finding significant correlations between PROMs and clinical assessments. PROMs could enable early-stage RRMS patients to communicate their perceived disability in different domains, assisting clinicians in disease monitoring and decision making.

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