Emergence of KPC-8-producing K. pneumoniae infection without prior exposure to ceftazidime/avibactam: the threat of de novo infections by ceftazidime/avibactam-resistant KPC variants

De novo infections caused by ceftazidime/avibactam-resistant KPC variants are rarely reported. We characterize the evolution of a KPC-8-producing Klebsiella pneumoniae strain involved in a primary infection without previous ceftazidime/avibactam treatment. During a 15-month follow-up, changes in car...

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Authors: Mateo-Vargas, María Alejandra, Rodríguez-Pallares, Salud, Arca-Suárez, Jorge, López Cerero, Lorena, Rodríguez-Iglesias, Manuel, Galán-Sánchez, Fátima
Format: article
Status:Published version
Publication Date:2025
Country:España
Institution:Universidad de Sevilla (US)
Repository:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/179055
Online Access:https://hdl.handle.net/11441/179055
https://doi.org/10.1128/aac.01494-24
Access Level:Open access
Keyword:KPC-8
Klebsiella pneumoniae
Ceftazidime/avibactam
KPC-31
Meropenem/vaborbactam
Evolution
Imipenem/relebactam
Cefiderocol
β-lactamase
Antimicrobial resistance
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spelling Emergence of KPC-8-producing K. pneumoniae infection without prior exposure to ceftazidime/avibactam: the threat of de novo infections by ceftazidime/avibactam-resistant KPC variantsMateo-Vargas, María AlejandraRodríguez-Pallares, SaludArca-Suárez, JorgeLópez Cerero, LorenaRodríguez-Iglesias, ManuelGalán-Sánchez, FátimaKPC-8Klebsiella pneumoniaeCeftazidime/avibactamKPC-31Meropenem/vaborbactamEvolutionImipenem/relebactamCefiderocolβ-lactamaseAntimicrobial resistanceDe novo infections caused by ceftazidime/avibactam-resistant KPC variants are rarely reported. We characterize the evolution of a KPC-8-producing Klebsiella pneumoniae strain involved in a primary infection without previous ceftazidime/avibactam treatment. During a 15-month follow-up, changes in carbapenem susceptibility due to porin alterations were observed, remaining susceptible to meropenem/vaborbactam, imipenem/relebactam, and cefiderocol. High- and low-permeability recombinant Escherichia coli isolates analysis revealed that, unlike the widespread ceftazidime/avibactam-resistant variant KPC-31, KPC-8 confers ceftazidime/avibactam resistance without decreasing carbapenemase activity.American Society for Microbiology (ASM) journalsMicrobiologíaInstituto de Salud Carlos IIIXunta de GaliciaCentro de Investigación Biotecnológica en Red de Enfermedades Infecciosas (CIBERINFEC)2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/179055https://doi.org/10.1128/aac.01494-24reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésAntimicrobial Agents and Chemotherapy, 69 (6), 69:e01494-24.PI22/01212CB21/13/00055CB21/13/00055JR21/00026https://doi.org/10.1128/aac.01494-24info:eu-repo/semantics/openAccessoai:idus.us.es:11441/1790552026-06-17T12:51:07Z
dc.title.none.fl_str_mv Emergence of KPC-8-producing K. pneumoniae infection without prior exposure to ceftazidime/avibactam: the threat of de novo infections by ceftazidime/avibactam-resistant KPC variants
title Emergence of KPC-8-producing K. pneumoniae infection without prior exposure to ceftazidime/avibactam: the threat of de novo infections by ceftazidime/avibactam-resistant KPC variants
spellingShingle Emergence of KPC-8-producing K. pneumoniae infection without prior exposure to ceftazidime/avibactam: the threat of de novo infections by ceftazidime/avibactam-resistant KPC variants
Mateo-Vargas, María Alejandra
KPC-8
Klebsiella pneumoniae
Ceftazidime/avibactam
KPC-31
Meropenem/vaborbactam
Evolution
Imipenem/relebactam
Cefiderocol
β-lactamase
Antimicrobial resistance
title_short Emergence of KPC-8-producing K. pneumoniae infection without prior exposure to ceftazidime/avibactam: the threat of de novo infections by ceftazidime/avibactam-resistant KPC variants
title_full Emergence of KPC-8-producing K. pneumoniae infection without prior exposure to ceftazidime/avibactam: the threat of de novo infections by ceftazidime/avibactam-resistant KPC variants
title_fullStr Emergence of KPC-8-producing K. pneumoniae infection without prior exposure to ceftazidime/avibactam: the threat of de novo infections by ceftazidime/avibactam-resistant KPC variants
title_full_unstemmed Emergence of KPC-8-producing K. pneumoniae infection without prior exposure to ceftazidime/avibactam: the threat of de novo infections by ceftazidime/avibactam-resistant KPC variants
title_sort Emergence of KPC-8-producing K. pneumoniae infection without prior exposure to ceftazidime/avibactam: the threat of de novo infections by ceftazidime/avibactam-resistant KPC variants
dc.creator.none.fl_str_mv Mateo-Vargas, María Alejandra
Rodríguez-Pallares, Salud
Arca-Suárez, Jorge
López Cerero, Lorena
Rodríguez-Iglesias, Manuel
Galán-Sánchez, Fátima
author Mateo-Vargas, María Alejandra
author_facet Mateo-Vargas, María Alejandra
Rodríguez-Pallares, Salud
Arca-Suárez, Jorge
López Cerero, Lorena
Rodríguez-Iglesias, Manuel
Galán-Sánchez, Fátima
author_role author
author2 Rodríguez-Pallares, Salud
Arca-Suárez, Jorge
López Cerero, Lorena
Rodríguez-Iglesias, Manuel
Galán-Sánchez, Fátima
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Microbiología
Instituto de Salud Carlos III
Xunta de Galicia
Centro de Investigación Biotecnológica en Red de Enfermedades Infecciosas (CIBERINFEC)
dc.subject.none.fl_str_mv KPC-8
Klebsiella pneumoniae
Ceftazidime/avibactam
KPC-31
Meropenem/vaborbactam
Evolution
Imipenem/relebactam
Cefiderocol
β-lactamase
Antimicrobial resistance
topic KPC-8
Klebsiella pneumoniae
Ceftazidime/avibactam
KPC-31
Meropenem/vaborbactam
Evolution
Imipenem/relebactam
Cefiderocol
β-lactamase
Antimicrobial resistance
description De novo infections caused by ceftazidime/avibactam-resistant KPC variants are rarely reported. We characterize the evolution of a KPC-8-producing Klebsiella pneumoniae strain involved in a primary infection without previous ceftazidime/avibactam treatment. During a 15-month follow-up, changes in carbapenem susceptibility due to porin alterations were observed, remaining susceptible to meropenem/vaborbactam, imipenem/relebactam, and cefiderocol. High- and low-permeability recombinant Escherichia coli isolates analysis revealed that, unlike the widespread ceftazidime/avibactam-resistant variant KPC-31, KPC-8 confers ceftazidime/avibactam resistance without decreasing carbapenemase activity.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/179055
https://doi.org/10.1128/aac.01494-24
url https://hdl.handle.net/11441/179055
https://doi.org/10.1128/aac.01494-24
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Antimicrobial Agents and Chemotherapy, 69 (6), 69:e01494-24.
PI22/01212
CB21/13/00055
CB21/13/00055
JR21/00026
https://doi.org/10.1128/aac.01494-24
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Society for Microbiology (ASM) journals
publisher.none.fl_str_mv American Society for Microbiology (ASM) journals
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.81155

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