Emergence of KPC-8-producing K. pneumoniae infection without prior exposure to ceftazidime/avibactam: the threat of de novo infections by ceftazidime/avibactam-resistant KPC variants

De novo infections caused by ceftazidime/avibactam-resistant KPC variants are rarely reported. We characterize the evolution of a KPC-8-producing Klebsiella pneumoniae strain involved in a primary infection without previous ceftazidime/avibactam treatment. During a 15-month follow-up, changes in car...

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Detalles Bibliográficos
Autores: Mateo-Vargas, María Alejandra, Rodríguez-Pallares, Salud, Arca-Suárez, Jorge, López Cerero, Lorena, Rodríguez-Iglesias, Manuel, Galán-Sánchez, Fátima
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/179055
Acceso en línea:https://hdl.handle.net/11441/179055
https://doi.org/10.1128/aac.01494-24
Access Level:acceso abierto
Palabra clave:KPC-8
Klebsiella pneumoniae
Ceftazidime/avibactam
KPC-31
Meropenem/vaborbactam
Evolution
Imipenem/relebactam
Cefiderocol
β-lactamase
Antimicrobial resistance
Descripción
Sumario:De novo infections caused by ceftazidime/avibactam-resistant KPC variants are rarely reported. We characterize the evolution of a KPC-8-producing Klebsiella pneumoniae strain involved in a primary infection without previous ceftazidime/avibactam treatment. During a 15-month follow-up, changes in carbapenem susceptibility due to porin alterations were observed, remaining susceptible to meropenem/vaborbactam, imipenem/relebactam, and cefiderocol. High- and low-permeability recombinant Escherichia coli isolates analysis revealed that, unlike the widespread ceftazidime/avibactam-resistant variant KPC-31, KPC-8 confers ceftazidime/avibactam resistance without decreasing carbapenemase activity.

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