Current Positioning against Severe Infections Due to Klebsiella pneumoniae in Hospitalized Adults.

Infections due to Klebsiella pneumoniae have been increasing in intensive care units (ICUs) in the last decade. Such infections pose a serious problem, especially when antimicrobial resistance is present. We created a task force of experts, including specialists in intensive care medicine, anaesthes...

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Detalles Bibliográficos
Autores: Vidal-Cortes, Pablo, Martin-Loeches, Ignacio, Rodriguez, Alejandro, Bou, German, Canton, Rafael, Diaz, Emili, De la Fuente, Carmen, Torre-Cisneros, Julian, Nuvials, Francisco Xavier, Salavert, Miguel, Aguilar, Gerardo, Nieto, Mercedes, Ramirez, Paula, Borges, Marcio, Soriano, Cruz, Ferrer, Ricard, Maseda, Emilio, Zaragoza, Rafael
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:INCLIVA
Repositorio:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
OAI Identifier:oai:incliva.fundanetsuite.com:p16907
Acceso en línea:https://incliva.portalinvestigacion.com/publicaciones/16907
Access Level:acceso abierto
Palabra clave:ICU
KPC
Klebsiella pneumoniae
VAP
carbapenemase-producing Enterobacterales (CPE)
cefiderocol
ceftazidime-avibactam
imipenem-relebactam
meropenem-vaborbactam
nosocomial pneumonia
Descripción
Sumario:Infections due to Klebsiella pneumoniae have been increasing in intensive care units (ICUs) in the last decade. Such infections pose a serious problem, especially when antimicrobial resistance is present. We created a task force of experts, including specialists in intensive care medicine, anaesthesia, microbiology and infectious diseases, selected on the basis of their varied experience in the field of nosocomial infections, who conducted a comprehensive review of the recently published literature on the management of carbapenemase-producing Enterobacterales (CPE) infections in the intensive care setting from 2012 to 2022 to summarize the best available treatment. The group established priorities regarding management, based on both the risk of developing infections caused by K. pneumoniae and the risk of poor outcome. Moreover, we reviewed and updated the most important clinical entities and the new antibiotic treatments recently developed. After analysis of the priorities outlined, this group of experts established a series of recommendations and designed a management algorithm.

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