Enzyme catalysed tandem reactions

To transfer to the laboratory, the excellent efficiency shown by enzymes in Nature, biocatalysis, had to mimic several synthetic strategies used by the living organisms. Biosynthetic pathways are examples of tandem catalysis and may be assimilated in the biocatalysis field for the use of isolated mu...

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Detalles Bibliográficos
Autores: Oroz-Guinea, Isabel, García-Junceda, Eduardo
Tipo de recurso: artículo
Fecha de publicación:2013
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/76592
Acceso en línea:http://hdl.handle.net/10261/76592
Access Level:acceso abierto
Palabra clave:Enzyme catalysed
Multi-enzyme systems
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spelling Enzyme catalysed tandem reactionsOroz-Guinea, IsabelGarcía-Junceda, EduardoEnzyme catalysedMulti-enzyme systemsTo transfer to the laboratory, the excellent efficiency shown by enzymes in Nature, biocatalysis, had to mimic several synthetic strategies used by the living organisms. Biosynthetic pathways are examples of tandem catalysis and may be assimilated in the biocatalysis field for the use of isolated multi-enzyme systems in the homogeneous phase. The concurrent action of several enzymes that work sequentially presents extraordinary advantages from the synthetic point of view, since it permits a reversible process to become irreversible, to shift the equilibrium reaction in such a way that enantiopure compounds can be obtained from prochiral or racemic substrates, reduce or eliminate problems due to product inhibition or prevent the shortage of substrates by dilution or degradation in the bulk media, etc. In this review we want to illustrate the developments of recent studies involving in vitro multi-enzyme reactions for the synthesis of different classes of organic compoundsThis work was supported by grants from the Spanish Ministerio de Ciencia e Innovación (Grant PI11/01436), Comunidad de Madrid (Grant S2009/ PPQ-1752). I. Oroz-Guinea is a JAEPredoc fellow from CSICPeer reviewedElsevier201320132013info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501http://hdl.handle.net/10261/76592reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1016/j.cbpa.2013.02.015info:eu-repo/semantics/openAccessoai:digital.csic.es:10261/765922026-05-22T06:33:51Z
dc.title.none.fl_str_mv Enzyme catalysed tandem reactions
title Enzyme catalysed tandem reactions
spellingShingle Enzyme catalysed tandem reactions
Oroz-Guinea, Isabel
Enzyme catalysed
Multi-enzyme systems
title_short Enzyme catalysed tandem reactions
title_full Enzyme catalysed tandem reactions
title_fullStr Enzyme catalysed tandem reactions
title_full_unstemmed Enzyme catalysed tandem reactions
title_sort Enzyme catalysed tandem reactions
dc.creator.none.fl_str_mv Oroz-Guinea, Isabel
García-Junceda, Eduardo
author Oroz-Guinea, Isabel
author_facet Oroz-Guinea, Isabel
García-Junceda, Eduardo
author_role author
author2 García-Junceda, Eduardo
author2_role author
dc.subject.none.fl_str_mv Enzyme catalysed
Multi-enzyme systems
topic Enzyme catalysed
Multi-enzyme systems
description To transfer to the laboratory, the excellent efficiency shown by enzymes in Nature, biocatalysis, had to mimic several synthetic strategies used by the living organisms. Biosynthetic pathways are examples of tandem catalysis and may be assimilated in the biocatalysis field for the use of isolated multi-enzyme systems in the homogeneous phase. The concurrent action of several enzymes that work sequentially presents extraordinary advantages from the synthetic point of view, since it permits a reversible process to become irreversible, to shift the equilibrium reaction in such a way that enantiopure compounds can be obtained from prochiral or racemic substrates, reduce or eliminate problems due to product inhibition or prevent the shortage of substrates by dilution or degradation in the bulk media, etc. In this review we want to illustrate the developments of recent studies involving in vitro multi-enzyme reactions for the synthesis of different classes of organic compounds
publishDate 2013
dc.date.none.fl_str_mv 2013
2013
2013
dc.type.none.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/76592
url http://hdl.handle.net/10261/76592
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.1016/j.cbpa.2013.02.015
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
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