Visual-area-specific tonic modulation of GABA release by endocannabinoids sets the activity and coordination of neocortical principal neurons

Perisomatic inhibition of pyramidal neurons (PNs) coordinates cortical network activity during sensory processing, and this role is mainly attributed to parvalbumin-expressing basket cells (BCs). However, cannabinoid receptor type 1 (CB1)-expressing interneurons are also BCs, but the connectivity an...

Descripción completa

Detalles Bibliográficos
Autores: Koukouli, F., Montmerle, M., Aguirre, A., De Brito Van Velze, M., Peixoto, J., Choudhary, V., Varilh, Marjorie, Julio-Kalajzic, Francisca, Allene, C., Méndez, Pablo, Zerlaut, Y., Marsicano, G., Schlüter, O.M., Rebola, Nelson, Bacci, Alberto, Lourenço, J.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/284949
Acceso en línea:http://hdl.handle.net/10261/284949
Access Level:acceso abierto
Palabra clave:CP: Neuroscience
endocannabinoids
Inhibition
interneurons
in vivo spontaneous activity
synaptic transmission
visual cortex.
Descripción
Sumario:Perisomatic inhibition of pyramidal neurons (PNs) coordinates cortical network activity during sensory processing, and this role is mainly attributed to parvalbumin-expressing basket cells (BCs). However, cannabinoid receptor type 1 (CB1)-expressing interneurons are also BCs, but the connectivity and function of these elusive but prominent neocortical inhibitory neurons are unclear. We find that their connectivity pattern is visual area specific. Persistently active CB1 signaling suppresses GABA release from CB1 BCs in the medial secondary visual cortex (V2M), but not in the primary visual cortex (V1). Accordingly, in vivo, tonic CB1 signaling is responsible for higher but less coordinated PN activity in the V2M than in the V1. These differential firing dynamics in the V1 and V2M can be captured by a computational network model that incorporates visual-area-specific properties. Our results indicate a differential CB1-mediated mechanism controlling PN activity, suggesting an alternative connectivity scheme of a specific GABAergic circuit in different cortical areas.

Similares en LA Referencia