Association of adiposity and its changes over time with COVID-19 risk in older adults with overweight/obesity and metabolic syndrome: a longitudinal evaluation in the PREDIMED-Plus cohort

Background: Cross-sectionally, older age and obesity are associated with increased coronavirus disease-2019 (COVID-19) risk. We assessed the longitudinal associations of baseline and changes in adiposity parameters with COVID-19 incidence in older adults at high cardiovascular risk. Methods: This an...

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Autores: Matía-Martín, Pilar, Shyam, Sangeetha, García Gavilán, Jesús, Paz-Graniel, Indira, Gaforio, José J., Martínez-González, Miguel Ángel, 1957-, Corella Piquer, Dolores, Martínez Hernández, José Alfredo, Alonso Gómez, Ángel M., Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López-Miranda, José, Estruch Riba, Ramon, Tinahones, Francisco José, Lapetra, José, Serra-Majem, Lluís, Bueno-Cavanillas, Aurora, Tur, Josep Antoni, Martín-Sánchez, V., Pintó Sala, Xavier, Vidal i Cortada, Josep, Vázquez, Clotilde, Daimiel, Lidia, Ros Rahola, Emilio, Fernández Aranda, Fernando, Nishi, Stephanie K, Garcia-Regata, Oscar, Toledo, Estefanía, Asensio, Eva M, Castañer Niño, Olga, Garcia-Rios, Antonio, Torres-Collado, Laura, Gómez Gracia, Enrique, Zulet, M. Angeles, Goñi Ruiz, Nuria, Casas Rodríguez, Rosa M., Cano Ibáñez, Naomi, Tojal Sierra, Lucas, Gómez-Perez, AM, Sorlí, José V., Cinza-Sanjurjo, Sergio, Martín-Peláez, Sandra, Peña-Orihuela, Patricia J, Oncina-Canovas, Alejandro, Perez-Araluce, Rafael, Zomeño, Maria Dolores, Chaplin, Alice, Delgado Rodriguez, Miguel, Babio, Nancy, Fitó Colomer, Montserrat, Salas-Salvadó, Jordi
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/225021
Acceso en línea:https://hdl.handle.net/2445/225021
Access Level:acceso abierto
Palabra clave:Obesitat
Vellesa
COVID-19
Obesity
Old age
Descripción
Sumario:Background: Cross-sectionally, older age and obesity are associated with increased coronavirus disease-2019 (COVID-19) risk. We assessed the longitudinal associations of baseline and changes in adiposity parameters with COVID-19 incidence in older adults at high cardiovascular risk. Methods: This analysis included 6874 men and women (aged 55-75 years) with overweight/obesity and metabolic syndrome in the PREDIMED-Plus lifestyle intervention trial for cardiovascular risk reduction. Body weight, body-mass-index (BMI), waist circumference, waist-to-height ratio (WHtR), and a body shape index (ABSI) were measured at baseline and annual follow-up visits. COVID-19 was ascertained by an independent Event Committee until 31 December 2021. Cox regression models were fitted to evaluate the risk of COVID-19 incidence based on baseline adiposity parameters measured 5-6 years before the pandemic and their changes at the visit prior to censoring. Results: At the time of censoring, 653 incident COVID-19 cases occurred. Higher baseline body weight, BMI, waist circumference, and WHtR were associated with increased COVID-19 risk. During the follow-up, every unit increase in body weight (HRadj (95%CI): 1.01 (1.00, 1.03)) and BMI (HRadj: 1.04 (1.003, 1.08)) was associated with increased COVID-19 risk. Conclusions: In older adults with overweight/obesity, clinically significant weight loss may protect against COVID-19.

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