Association of adiposity and its changes over time with COVID‑19 risk in older adults with overweight/obesity and metabolic syndrome: a longitudinal evaluation in the PREDIMED‑Plus cohort

Abstract Background Cross-sectionally, older age and obesity are associated with increased coronavirus disease-2019 (COVID-19) risk. We assessed the longitudinal associations of baseline and changes in adiposity parameters with COVID-19 incidence in older adults at high cardiovascular risk. Methods...

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Autores: Shyam, Sangeetha, García-Gavilán, Jesús, Paz Graniel, Indira, Gaforio, Jose J, Martínez-González, Miguel Ángel, Corella Piquer, Dolores, Martínez, José Alfredo, Alonso Gómez, Ángel M., Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López Miranda, José, Estruch Riba, Ramon, Tinahones Madueño, Francisco J., Lapetra, José, Serra Majem, Lluís, Bueno-Cavanillas, Aurora, Tur, Josep A., Martín Sánchez, Vicente, Pintó Sala, Xavier, Matía Martín, Pilar, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Ros, Emilio, Fernández-Aranda, Fernando, Nishi, Stephanie K., Garcia‑Regata, Oscar, Toledo, Estefanía, Asensio, Eva Maria, Castañer, Olga, Garcia-Rios, Antonio, Torres-Collado, Laura, Gómez-Gracia, Enrique, Zulet, M. Angeles, Goñi, Nuria, Casas, Rosa, Cano-Ibáñez, Naomi, Tojal Sierra, Lucas, Gómez-Pérez, Ana Maria, Sorlí, José V., Cinza-Sanjurjo, Sergio, Martín‑Peláez, Sandra, Peña Orihuela, Patricia J, Oncina Canovas, Alejandro, Pérez-Araluce, Rafael, Zomeño, M. Dolores, Chaplin, Alice, Delgado-Rodríguez, Miguel, Babio, Nancy, Fitó Colomer, Montserrat, Salas Salvadó, Jordi
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universitat Ramon Llull (URL)
Repositorio:DAU Arxiu Digital de la Universitat Ramon Llull
OAI Identifier:oai:dau.url.edu:20.500.14342/5269
Acceso en línea:http://hdl.handle.net/20.500.14342/5269
https://doi.org/10.1186/s12916-023-03079-z
Access Level:acceso abierto
Palabra clave:Obesitat
COVID-19 (Malaltia)
Persones grans
Aprimament
Descripción
Sumario:Abstract Background Cross-sectionally, older age and obesity are associated with increased coronavirus disease-2019 (COVID-19) risk. We assessed the longitudinal associations of baseline and changes in adiposity parameters with COVID-19 incidence in older adults at high cardiovascular risk. Methods This analysis included 6874 men and women (aged 55–75 years) with overweight/obesity and metabolic syndrome in the PREDIMED-Plus lifestyle intervention trial for cardiovascular risk reduction. Body weight, body-mass-index (BMI), waist circumference, waist-to-height ratio (WHtR), and a body shape index (ABSI) were measured at baseline and annual follow-up visits. COVID-19 was ascertained by an independent Event Committee until 31 December 2021. Cox regression models were fitted to evaluate the risk of COVID-19 incidence based on baseline adiposity parameters measured 5–6 years before the pandemic and their changes at the visit prior to censoring. Results At the time of censoring, 653 incident COVID-19 cases occurred. Higher baseline body weight, BMI, waist circumference, and WHtR were associated with increased COVID-19 risk. During the follow-up, every unit increase in body weight (HRadj (95%CI): 1.01 (1.00, 1.03)) and BMI (HRadj: 1.04 (1.003, 1.08)) was associated with increased COVID-19 risk. Conclusions In older adults with overweight/obesity, clinically significant weight loss may protect against COVID-19.

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