Widefield SERS for High-Throughput Nanoparticle Screening

Surface-enhanced Raman scattering (SERS) imaging is a powerful technology with unprecedent potential for ultrasensitive chemical analysis. Point-by-point scanning and often excessively long spectral acquisition-times hamper the broad exploitation of the full analytical potential of SERS. Here, we in...

Descripción completa

Detalles Bibliográficos
Autores: Liebel, Matz, Calderon, Irene, Pazos-Perez, Nicolas, Hulst, Niek van, Alvarez-Puebla, Ramon A
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universitat Politècnica de Catalunya (UPC)
Repositorio:UPCommons. Portal del coneixement obert de la UPC
Idioma:inglés
OAI Identifier:oai:upcommons.upc.edu:2117/361685
Acceso en línea:https://hdl.handle.net/2117/361685
https://dx.doi.org/10.1002/anie.202200072
Access Level:acceso abierto
Palabra clave:Raman spectroscopy
nanoparticles
Espectroscòpia Raman
Àrees temàtiques de la UPC::Física
id ES_818375cd4658cf67b2a67b01e575accb
oai_identifier_str oai:upcommons.upc.edu:2117/361685
network_acronym_str ES
network_name_str España
repository_id_str
spelling Widefield SERS for High-Throughput Nanoparticle ScreeningLiebel, MatzCalderon, IrenePazos-Perez, NicolasHulst, Niek vanAlvarez-Puebla, Ramon ARaman spectroscopynanoparticlesEspectroscòpia RamanÀrees temàtiques de la UPC::FísicaSurface-enhanced Raman scattering (SERS) imaging is a powerful technology with unprecedent potential for ultrasensitive chemical analysis. Point-by-point scanning and often excessively long spectral acquisition-times hamper the broad exploitation of the full analytical potential of SERS. Here, we introduce large scale SERS particle screening (LSSPS), a multiplexed widefield screening approach to particle-characterization, which is 500-1000 times faster than typical confocal Raman implementations. Beyond its higher throughput, LSSPS simultaneously quantifies both the sample’s Raman and Rayleigh scattering, allowing for an unprecedented correlation of SERS activity with the particle-size and to directly quantify the fraction of SERS active particles.Peer ReviewedWiley20222022-02-0220222022-02-04journal articlehttp://purl.org/coar/resource_type/c_6501AMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/2117/361685https://dx.doi.org/10.1002/anie.202200072reponame:UPCommons. Portal del coneixement obert de la UPCinstname:Universitat Politècnica de Catalunya (UPC)InglésengAgencia Estatal de Investigación http://doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 RTI2018-099957-J-I00 VISUALIZACION EN 3D DE PROCESOS DINAMICOS EN CELULAS VIVASEuropean Commission http://doi.org/10.13039/100010661 Horizon 2020 Framework Programme 670949 LightNetAgencia Estatal de Investigación http://doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 PID2020-120306RB-I00 INTEGRAL STAGING, PROGNOSTIC AND DIAGNOSTIC OF CANCER IN LIQUID SAMPLES THROUGH OPTICAL METHODSopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 3.0 Spainhttp://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:upcommons.upc.edu:2117/3616852026-05-27T15:37:01Z
dc.title.none.fl_str_mv Widefield SERS for High-Throughput Nanoparticle Screening
title Widefield SERS for High-Throughput Nanoparticle Screening
spellingShingle Widefield SERS for High-Throughput Nanoparticle Screening
Liebel, Matz
Raman spectroscopy
nanoparticles
Espectroscòpia Raman
Àrees temàtiques de la UPC::Física
title_short Widefield SERS for High-Throughput Nanoparticle Screening
title_full Widefield SERS for High-Throughput Nanoparticle Screening
title_fullStr Widefield SERS for High-Throughput Nanoparticle Screening
title_full_unstemmed Widefield SERS for High-Throughput Nanoparticle Screening
title_sort Widefield SERS for High-Throughput Nanoparticle Screening
dc.creator.none.fl_str_mv Liebel, Matz
Calderon, Irene
Pazos-Perez, Nicolas
Hulst, Niek van
Alvarez-Puebla, Ramon A
author Liebel, Matz
author_facet Liebel, Matz
Calderon, Irene
Pazos-Perez, Nicolas
Hulst, Niek van
Alvarez-Puebla, Ramon A
author_role author
author2 Calderon, Irene
Pazos-Perez, Nicolas
Hulst, Niek van
Alvarez-Puebla, Ramon A
author2_role author
author
author
author
dc.subject.none.fl_str_mv Raman spectroscopy
nanoparticles
Espectroscòpia Raman
Àrees temàtiques de la UPC::Física
topic Raman spectroscopy
nanoparticles
Espectroscòpia Raman
Àrees temàtiques de la UPC::Física
description Surface-enhanced Raman scattering (SERS) imaging is a powerful technology with unprecedent potential for ultrasensitive chemical analysis. Point-by-point scanning and often excessively long spectral acquisition-times hamper the broad exploitation of the full analytical potential of SERS. Here, we introduce large scale SERS particle screening (LSSPS), a multiplexed widefield screening approach to particle-characterization, which is 500-1000 times faster than typical confocal Raman implementations. Beyond its higher throughput, LSSPS simultaneously quantifies both the sample’s Raman and Rayleigh scattering, allowing for an unprecedented correlation of SERS activity with the particle-size and to directly quantify the fraction of SERS active particles.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-02-02
2022
2022-02-04
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
AM
http://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/2117/361685
https://dx.doi.org/10.1002/anie.202200072
url https://hdl.handle.net/2117/361685
https://dx.doi.org/10.1002/anie.202200072
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Agencia Estatal de Investigación http://doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 RTI2018-099957-J-I00 VISUALIZACION EN 3D DE PROCESOS DINAMICOS EN CELULAS VIVAS
European Commission http://doi.org/10.13039/100010661 Horizon 2020 Framework Programme 670949 LightNet
Agencia Estatal de Investigación http://doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 PID2020-120306RB-I00 INTEGRAL STAGING, PROGNOSTIC AND DIAGNOSTIC OF CANCER IN LIQUID SAMPLES THROUGH OPTICAL METHODS
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 3.0 Spain
http://creativecommons.org/licenses/by/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 3.0 Spain
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:UPCommons. Portal del coneixement obert de la UPC
instname:Universitat Politècnica de Catalunya (UPC)
instname_str Universitat Politècnica de Catalunya (UPC)
reponame_str UPCommons. Portal del coneixement obert de la UPC
collection UPCommons. Portal del coneixement obert de la UPC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869411979152588800
score 15,300719

Similares en LA Referencia