Translation of a tissue epigenetic signature to circulating free DNA suggests <i>BCAT1</i> as a potential noninvasive diagnostic biomarker for lung cancer

Lung cancer patients are diagnosed at late stages when curative treatments are no longer possible; thus, molecular biomarkers for noninvasive detection are urgently needed. In this sense, we previously identified and validated an epigenetic 4-gene signature that yielded a high diagnostic performance...

Descripción completa

Detalles Bibliográficos
Autores: Palanca-Ballester, C, Hervas, D, Villalba, M, Valdes-Sanchez, T, Garcia, D, Alcoriza-Balaguer, MI, Benet, M, Martinez-Tomas, R, Briones-Gomez, A, Galbis-Caravajal, J, Calvo, A, Juan, O, Lahoz, A, Cases, E, Sandoval, J
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Repositorio:r-FISABIO. Repositorio Institucional de Producción Científica
OAI Identifier:oai:fisabio.fundanetsuite.com:p14682
Acceso en línea:https://fisabio.portalinvestigacion.com/publicaciones/14682
Access Level:acceso abierto
Palabra clave:Epigenetics
DNA methylation
ddPCR
Plasma
Circulating DNA
BCAT1
Lung cancer
Noninvasive
id ES_80569dbb22daa2bceee867faf77357f4
oai_identifier_str oai:fisabio.fundanetsuite.com:p14682
network_acronym_str ES
network_name_str España
repository_id_str
spelling Translation of a tissue epigenetic signature to circulating free DNA suggests <i>BCAT1</i> as a potential noninvasive diagnostic biomarker for lung cancerPalanca-Ballester, CHervas, DVillalba, MValdes-Sanchez, TGarcia, DAlcoriza-Balaguer, MIBenet, MMartinez-Tomas, RBriones-Gomez, AGalbis-Caravajal, JCalvo, AJuan, OLahoz, ACases, ESandoval, JEpigeneticsDNA methylationddPCRPlasmaCirculating DNABCAT1Lung cancerNoninvasiveLung cancer patients are diagnosed at late stages when curative treatments are no longer possible; thus, molecular biomarkers for noninvasive detection are urgently needed. In this sense, we previously identified and validated an epigenetic 4-gene signature that yielded a high diagnostic performance in tissue and invasive pulmonary fluids. We analyzed DNA methylation levels using the ultrasensitive digital droplet PCR in noninvasive samples in a cohort of 83 patients. We demonstrated that BCAT1 is the candidate that achieves high diagnostic efficacy in circulating DNA derived from plasma (area under the curve: 0.85). Impact of potentially confounding variables was also explored.BMC2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fisabio.portalinvestigacion.com/publicaciones/14682Clinical EpigeneticsISSN: 18687075ISSNe: 18687083reponame:r-FISABIO. Repositorio Institucional de Producción Científicainstname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)Inglésinfo:eu-repo/semantics/openAccessoai:fisabio.fundanetsuite.com:p146822026-06-11T12:45:17Z
dc.title.none.fl_str_mv Translation of a tissue epigenetic signature to circulating free DNA suggests <i>BCAT1</i> as a potential noninvasive diagnostic biomarker for lung cancer
title Translation of a tissue epigenetic signature to circulating free DNA suggests <i>BCAT1</i> as a potential noninvasive diagnostic biomarker for lung cancer
spellingShingle Translation of a tissue epigenetic signature to circulating free DNA suggests <i>BCAT1</i> as a potential noninvasive diagnostic biomarker for lung cancer
Palanca-Ballester, C
Epigenetics
DNA methylation
ddPCR
Plasma
Circulating DNA
BCAT1
Lung cancer
Noninvasive
title_short Translation of a tissue epigenetic signature to circulating free DNA suggests <i>BCAT1</i> as a potential noninvasive diagnostic biomarker for lung cancer
title_full Translation of a tissue epigenetic signature to circulating free DNA suggests <i>BCAT1</i> as a potential noninvasive diagnostic biomarker for lung cancer
title_fullStr Translation of a tissue epigenetic signature to circulating free DNA suggests <i>BCAT1</i> as a potential noninvasive diagnostic biomarker for lung cancer
title_full_unstemmed Translation of a tissue epigenetic signature to circulating free DNA suggests <i>BCAT1</i> as a potential noninvasive diagnostic biomarker for lung cancer
title_sort Translation of a tissue epigenetic signature to circulating free DNA suggests <i>BCAT1</i> as a potential noninvasive diagnostic biomarker for lung cancer
dc.creator.none.fl_str_mv Palanca-Ballester, C
Hervas, D
Villalba, M
Valdes-Sanchez, T
Garcia, D
Alcoriza-Balaguer, MI
Benet, M
Martinez-Tomas, R
Briones-Gomez, A
Galbis-Caravajal, J
Calvo, A
Juan, O
Lahoz, A
Cases, E
Sandoval, J
author Palanca-Ballester, C
author_facet Palanca-Ballester, C
Hervas, D
Villalba, M
Valdes-Sanchez, T
Garcia, D
Alcoriza-Balaguer, MI
Benet, M
Martinez-Tomas, R
Briones-Gomez, A
Galbis-Caravajal, J
Calvo, A
Juan, O
Lahoz, A
Cases, E
Sandoval, J
author_role author
author2 Hervas, D
Villalba, M
Valdes-Sanchez, T
Garcia, D
Alcoriza-Balaguer, MI
Benet, M
Martinez-Tomas, R
Briones-Gomez, A
Galbis-Caravajal, J
Calvo, A
Juan, O
Lahoz, A
Cases, E
Sandoval, J
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Epigenetics
DNA methylation
ddPCR
Plasma
Circulating DNA
BCAT1
Lung cancer
Noninvasive
topic Epigenetics
DNA methylation
ddPCR
Plasma
Circulating DNA
BCAT1
Lung cancer
Noninvasive
description Lung cancer patients are diagnosed at late stages when curative treatments are no longer possible; thus, molecular biomarkers for noninvasive detection are urgently needed. In this sense, we previously identified and validated an epigenetic 4-gene signature that yielded a high diagnostic performance in tissue and invasive pulmonary fluids. We analyzed DNA methylation levels using the ultrasensitive digital droplet PCR in noninvasive samples in a cohort of 83 patients. We demonstrated that BCAT1 is the candidate that achieves high diagnostic efficacy in circulating DNA derived from plasma (area under the curve: 0.85). Impact of potentially confounding variables was also explored.
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fisabio.portalinvestigacion.com/publicaciones/14682
url https://fisabio.portalinvestigacion.com/publicaciones/14682
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BMC
publisher.none.fl_str_mv BMC
dc.source.none.fl_str_mv Clinical Epigenetics
ISSN: 18687075
ISSNe: 18687083
reponame:r-FISABIO. Repositorio Institucional de Producción Científica
instname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
instname_str Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
reponame_str r-FISABIO. Repositorio Institucional de Producción Científica
collection r-FISABIO. Repositorio Institucional de Producción Científica
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869411891279822848
score 15.812455

Similares en LA Referencia