Dietary Intake of 91 Individual Polyphenols and 5-Year Body Weight Change in the EPIC-PANACEA Cohort
Polyphenols are bioactive compounds from plants with antioxidant properties that may have a protective role against body weight gain, with adipose tissue and systemic oxidative stress as potential targets. We aimed to investigate the dietary intake of individual polyphenols and their association wit...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2022 |
| País: | España |
| Institución: | Universidad de Barcelona |
| Repositorio: | Dipòsit Digital de la UB |
| OAI Identifier: | oai:diposit.ub.edu:2445/192249 |
| Acceso en línea: | https://hdl.handle.net/2445/192249 |
| Access Level: | acceso abierto |
| Palabra clave: | Polifenols Pes corporal Obesitat Estrès oxidatiu Polyphenols Body weight Obesity Oxidative stress |
| id |
ES_7f152db76202cd5799dac2afdeac4629 |
|---|---|
| oai_identifier_str |
oai:diposit.ub.edu:2445/192249 |
| network_acronym_str |
ES |
| network_name_str |
España |
| repository_id_str |
|
| spelling |
Dietary Intake of 91 Individual Polyphenols and 5-Year Body Weight Change in the EPIC-PANACEA CohortGil Lespinard, MercedesCastañeda, JazmínAlmanza Aguilera, EnriqueGómez, Jesús HumbertoTjønneland, AnneKyrø, CecilieOvervad, KimKatzke, VerenaSchulze, Matthias B.Masala, GiovannaAgnoli, ClaudiaSantucci de Magistris, MariaTumino, RosarioSacerdote, CarlottaSkeie, GuriLasheras, CristinaMolina Montes, EstherHuerta, José MaríaBarricarte, AurelioAmiano, PilarSonestedt, EmilyDa Silva, MarisaJohansson, IngegerdHultdin, JohanMay, Anne M.Forouhi, Nita G.Heath, Alicia K.Freisling, HeinzWeiderpass, ElisabeteScalbert, AugustinZamora-Ros, RaulPolifenolsPes corporalObesitatEstrès oxidatiuPolyphenolsBody weightObesityOxidative stressPolyphenols are bioactive compounds from plants with antioxidant properties that may have a protective role against body weight gain, with adipose tissue and systemic oxidative stress as potential targets. We aimed to investigate the dietary intake of individual polyphenols and their association with 5-year body weight change in a sub-cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC). This study included 349,165 adult participants from nine European countries. Polyphenol intake was estimated through country-specific validated dietary questionnaires and the Phenol-Explorer database. Body weight was obtained at recruitment and after a mean follow-up time of 5 years. Associations were estimated using multilevel mixed linear regression models. From 91 polyphenols included, the majority (n = 67) were inversely associated with 5-year body weight change after FDR-correction (q < 0.05). The greatest inverse associations were observed for quercetin 3-O-rhamnoside (change in weight for doubling in intake: -0.071 (95% CI: -0.085; -0.056) kg/5 years). Only 13 polyphenols showed positive associations with body weight gain, mainly from the subclass hydroxycinnamic acids (HCAs) with coffee as the main dietary source, such as 4-caffeoylquinic acid (0.029 (95% CI: 0.021; 0.038) kg/5 years). Individual polyphenols with fruit, tea, cocoa and whole grain cereals as the main dietary sources may contribute to body weight maintenance in adults. Individual HCAs may have different roles in body weight change depending on their dietary source.MDPI AG2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/192249Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3390/antiox11122425Antioxidants, 2022, vol. 11, num. 12, p. 2425https://doi.org/10.3390/antiox11122425cc by (c) Gil Lespinard, Mercedes et al., 2022http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1922492026-05-27T06:46:51Z |
| dc.title.none.fl_str_mv |
Dietary Intake of 91 Individual Polyphenols and 5-Year Body Weight Change in the EPIC-PANACEA Cohort |
| title |
Dietary Intake of 91 Individual Polyphenols and 5-Year Body Weight Change in the EPIC-PANACEA Cohort |
| spellingShingle |
Dietary Intake of 91 Individual Polyphenols and 5-Year Body Weight Change in the EPIC-PANACEA Cohort Gil Lespinard, Mercedes Polifenols Pes corporal Obesitat Estrès oxidatiu Polyphenols Body weight Obesity Oxidative stress |
| title_short |
Dietary Intake of 91 Individual Polyphenols and 5-Year Body Weight Change in the EPIC-PANACEA Cohort |
| title_full |
Dietary Intake of 91 Individual Polyphenols and 5-Year Body Weight Change in the EPIC-PANACEA Cohort |
| title_fullStr |
Dietary Intake of 91 Individual Polyphenols and 5-Year Body Weight Change in the EPIC-PANACEA Cohort |
| title_full_unstemmed |
Dietary Intake of 91 Individual Polyphenols and 5-Year Body Weight Change in the EPIC-PANACEA Cohort |
| title_sort |
Dietary Intake of 91 Individual Polyphenols and 5-Year Body Weight Change in the EPIC-PANACEA Cohort |
| dc.creator.none.fl_str_mv |
Gil Lespinard, Mercedes Castañeda, Jazmín Almanza Aguilera, Enrique Gómez, Jesús Humberto Tjønneland, Anne Kyrø, Cecilie Overvad, Kim Katzke, Verena Schulze, Matthias B. Masala, Giovanna Agnoli, Claudia Santucci de Magistris, Maria Tumino, Rosario Sacerdote, Carlotta Skeie, Guri Lasheras, Cristina Molina Montes, Esther Huerta, José María Barricarte, Aurelio Amiano, Pilar Sonestedt, Emily Da Silva, Marisa Johansson, Ingegerd Hultdin, Johan May, Anne M. Forouhi, Nita G. Heath, Alicia K. Freisling, Heinz Weiderpass, Elisabete Scalbert, Augustin Zamora-Ros, Raul |
| author |
Gil Lespinard, Mercedes |
| author_facet |
Gil Lespinard, Mercedes Castañeda, Jazmín Almanza Aguilera, Enrique Gómez, Jesús Humberto Tjønneland, Anne Kyrø, Cecilie Overvad, Kim Katzke, Verena Schulze, Matthias B. Masala, Giovanna Agnoli, Claudia Santucci de Magistris, Maria Tumino, Rosario Sacerdote, Carlotta Skeie, Guri Lasheras, Cristina Molina Montes, Esther Huerta, José María Barricarte, Aurelio Amiano, Pilar Sonestedt, Emily Da Silva, Marisa Johansson, Ingegerd Hultdin, Johan May, Anne M. Forouhi, Nita G. Heath, Alicia K. Freisling, Heinz Weiderpass, Elisabete Scalbert, Augustin Zamora-Ros, Raul |
| author_role |
author |
| author2 |
Castañeda, Jazmín Almanza Aguilera, Enrique Gómez, Jesús Humberto Tjønneland, Anne Kyrø, Cecilie Overvad, Kim Katzke, Verena Schulze, Matthias B. Masala, Giovanna Agnoli, Claudia Santucci de Magistris, Maria Tumino, Rosario Sacerdote, Carlotta Skeie, Guri Lasheras, Cristina Molina Montes, Esther Huerta, José María Barricarte, Aurelio Amiano, Pilar Sonestedt, Emily Da Silva, Marisa Johansson, Ingegerd Hultdin, Johan May, Anne M. Forouhi, Nita G. Heath, Alicia K. Freisling, Heinz Weiderpass, Elisabete Scalbert, Augustin Zamora-Ros, Raul |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Polifenols Pes corporal Obesitat Estrès oxidatiu Polyphenols Body weight Obesity Oxidative stress |
| topic |
Polifenols Pes corporal Obesitat Estrès oxidatiu Polyphenols Body weight Obesity Oxidative stress |
| description |
Polyphenols are bioactive compounds from plants with antioxidant properties that may have a protective role against body weight gain, with adipose tissue and systemic oxidative stress as potential targets. We aimed to investigate the dietary intake of individual polyphenols and their association with 5-year body weight change in a sub-cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC). This study included 349,165 adult participants from nine European countries. Polyphenol intake was estimated through country-specific validated dietary questionnaires and the Phenol-Explorer database. Body weight was obtained at recruitment and after a mean follow-up time of 5 years. Associations were estimated using multilevel mixed linear regression models. From 91 polyphenols included, the majority (n = 67) were inversely associated with 5-year body weight change after FDR-correction (q < 0.05). The greatest inverse associations were observed for quercetin 3-O-rhamnoside (change in weight for doubling in intake: -0.071 (95% CI: -0.085; -0.056) kg/5 years). Only 13 polyphenols showed positive associations with body weight gain, mainly from the subclass hydroxycinnamic acids (HCAs) with coffee as the main dietary source, such as 4-caffeoylquinic acid (0.029 (95% CI: 0.021; 0.038) kg/5 years). Individual polyphenols with fruit, tea, cocoa and whole grain cereals as the main dietary sources may contribute to body weight maintenance in adults. Individual HCAs may have different roles in body weight change depending on their dietary source. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/2445/192249 |
| url |
https://hdl.handle.net/2445/192249 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Reproducció del document publicat a: https://doi.org/10.3390/antiox11122425 Antioxidants, 2022, vol. 11, num. 12, p. 2425 https://doi.org/10.3390/antiox11122425 |
| dc.rights.none.fl_str_mv |
cc by (c) Gil Lespinard, Mercedes et al., 2022 http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
cc by (c) Gil Lespinard, Mercedes et al., 2022 http://creativecommons.org/licenses/by/3.0/es/ |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
MDPI AG |
| publisher.none.fl_str_mv |
MDPI AG |
| dc.source.none.fl_str_mv |
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) reponame:Dipòsit Digital de la UB instname:Universidad de Barcelona |
| instname_str |
Universidad de Barcelona |
| reponame_str |
Dipòsit Digital de la UB |
| collection |
Dipòsit Digital de la UB |
| repository.name.fl_str_mv |
|
| repository.mail.fl_str_mv |
|
| _version_ |
1869411797844361216 |
| score |
15,301603 |