Dietary vitamin D and gastric cancer risk within the stomach cancer pooling (stop) project

PurposeThe evidence regarding the role of vitamin D on gastric cancer (GC) is controversial. Within the Stomach cancer Pooling (StoP) Project, a global consortium of epidemiological studies on GC, we aimed to evaluate the relationship between dietary vitamin D and GC risk.MethodsFive case-control st...

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Autores: Santucci, C, Natale, A, Pelucchi, C, Bonzi, R, Lunet, N, Morais, S, Vioque, J, González-Palacios, S, Aragonés, N, Castaño-Vinyals, G, Malekzadeh, R, Pakseresht, M, Negri, E, Boffetta, P, Camargo, MC, Curado, MP, Zhang, ZF, Boccia, S, La Vecchia, C, Rossi, M
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
Repositorio:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
OAI Identifier:oai:isabial.fundanetsuite.com:p11306
Acceso en línea:https://isabial.portalinvestigacion.com/publicaciones11306
https://doi.org/10.1007/s00394-025-03768-w
Access Level:acceso abierto
Palabra clave:Dietary vitamin D
Epidemiology
Gastric cancer
Pooled analysis
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spelling Dietary vitamin D and gastric cancer risk within the stomach cancer pooling (stop) projectSantucci, CNatale, APelucchi, CBonzi, RLunet, NMorais, SVioque, JGonzález-Palacios, SAragonés, NCastaño-Vinyals, GMalekzadeh, RPakseresht, MNegri, EBoffetta, PCamargo, MCCurado, MPZhang, ZFBoccia, SLa Vecchia, CRossi, MDietary vitamin DEpidemiologyGastric cancerPooled analysisPurposeThe evidence regarding the role of vitamin D on gastric cancer (GC) is controversial. Within the Stomach cancer Pooling (StoP) Project, a global consortium of epidemiological studies on GC, we aimed to evaluate the relationship between dietary vitamin D and GC risk.MethodsFive case-control studies were included in the analysis, accounting for 1875 cases and 5899 controls. Odds ratios (OR) of GC and the corresponding 95% confidence intervals (CI) for tertiles of vitamin D intake were computed using logistic regression models adjusted for relevant confounders, including energy intake. The pooled ORs were computed using random-effect models.ResultsThe pooled OR of GC for the highest compared to the lowest tertile of vitamin D intake was 1.06 (95% CI 0.80-1.39), with a p for heterogeneity of 0.019. No significant association was found across strata of sex, age, socioeconomic status, smoking status, alcohol intake, and vegetable and fruit consumption.ConclusionsOur pooled analysis indicates that there is no association between dietary vitamin D and the risk of GC.SPRINGER HEIDELBERG2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://isabial.portalinvestigacion.com/publicaciones11306https://doi.org/10.1007/s00394-025-03768-wEUROPEAN JOURNAL OF NUTRITIONISSN: 14366207ISSNe: 14366215reponame:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicanteinstname:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)Inglésinfo:eu-repo/semantics/openAccessoai:isabial.fundanetsuite.com:p113062026-06-12T10:20:37Z
dc.title.none.fl_str_mv Dietary vitamin D and gastric cancer risk within the stomach cancer pooling (stop) project
title Dietary vitamin D and gastric cancer risk within the stomach cancer pooling (stop) project
spellingShingle Dietary vitamin D and gastric cancer risk within the stomach cancer pooling (stop) project
Santucci, C
Dietary vitamin D
Epidemiology
Gastric cancer
Pooled analysis
title_short Dietary vitamin D and gastric cancer risk within the stomach cancer pooling (stop) project
title_full Dietary vitamin D and gastric cancer risk within the stomach cancer pooling (stop) project
title_fullStr Dietary vitamin D and gastric cancer risk within the stomach cancer pooling (stop) project
title_full_unstemmed Dietary vitamin D and gastric cancer risk within the stomach cancer pooling (stop) project
title_sort Dietary vitamin D and gastric cancer risk within the stomach cancer pooling (stop) project
dc.creator.none.fl_str_mv Santucci, C
Natale, A
Pelucchi, C
Bonzi, R
Lunet, N
Morais, S
Vioque, J
González-Palacios, S
Aragonés, N
Castaño-Vinyals, G
Malekzadeh, R
Pakseresht, M
Negri, E
Boffetta, P
Camargo, MC
Curado, MP
Zhang, ZF
Boccia, S
La Vecchia, C
Rossi, M
author Santucci, C
author_facet Santucci, C
Natale, A
Pelucchi, C
Bonzi, R
Lunet, N
Morais, S
Vioque, J
González-Palacios, S
Aragonés, N
Castaño-Vinyals, G
Malekzadeh, R
Pakseresht, M
Negri, E
Boffetta, P
Camargo, MC
Curado, MP
Zhang, ZF
Boccia, S
La Vecchia, C
Rossi, M
author_role author
author2 Natale, A
Pelucchi, C
Bonzi, R
Lunet, N
Morais, S
Vioque, J
González-Palacios, S
Aragonés, N
Castaño-Vinyals, G
Malekzadeh, R
Pakseresht, M
Negri, E
Boffetta, P
Camargo, MC
Curado, MP
Zhang, ZF
Boccia, S
La Vecchia, C
Rossi, M
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Dietary vitamin D
Epidemiology
Gastric cancer
Pooled analysis
topic Dietary vitamin D
Epidemiology
Gastric cancer
Pooled analysis
description PurposeThe evidence regarding the role of vitamin D on gastric cancer (GC) is controversial. Within the Stomach cancer Pooling (StoP) Project, a global consortium of epidemiological studies on GC, we aimed to evaluate the relationship between dietary vitamin D and GC risk.MethodsFive case-control studies were included in the analysis, accounting for 1875 cases and 5899 controls. Odds ratios (OR) of GC and the corresponding 95% confidence intervals (CI) for tertiles of vitamin D intake were computed using logistic regression models adjusted for relevant confounders, including energy intake. The pooled ORs were computed using random-effect models.ResultsThe pooled OR of GC for the highest compared to the lowest tertile of vitamin D intake was 1.06 (95% CI 0.80-1.39), with a p for heterogeneity of 0.019. No significant association was found across strata of sex, age, socioeconomic status, smoking status, alcohol intake, and vegetable and fruit consumption.ConclusionsOur pooled analysis indicates that there is no association between dietary vitamin D and the risk of GC.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://isabial.portalinvestigacion.com/publicaciones11306
https://doi.org/10.1007/s00394-025-03768-w
url https://isabial.portalinvestigacion.com/publicaciones11306
https://doi.org/10.1007/s00394-025-03768-w
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv SPRINGER HEIDELBERG
publisher.none.fl_str_mv SPRINGER HEIDELBERG
dc.source.none.fl_str_mv EUROPEAN JOURNAL OF NUTRITION
ISSN: 14366207
ISSNe: 14366215
reponame:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
instname:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
instname_str Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
reponame_str r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
collection r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.81155

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