Fish Oil Enriched Intravenous Lipid Emulsions Reduce Triglyceride Levels in Non-Critically Ill Patients with TPN and Type 2 Diabetes. A Post-Hoc Analysis of the INSUPAR Study

There are no studies that have specifically assessed the role of intravenous lipid emulsions (ILE) enriched with fish oil in people with diabetes receiving total parenteral nutrition (TPN). The objective of this study was to assess the metabolic control (glycemic and lipid) and in-hospital complicat...

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Autores: Abuin-Fernandez, J, Tapia-Guerrero, MJ, Lopez-Urdiales, R, Herranz-Antolin, S, Garcia-Almeida, JM, Garcia-Malpartida, K, Ferrer-Gomez, M, Cancer-Minchot, E, Luengo-Perez, LM, Alvarez-Hernandez, J, Valera, CA, Ocon-Breton, J, Garcia-Manzanares, A, Breton-Lesmes, I, Serrano-Aguayo, P, Perez-Ferre, N, Lopez-Gomez, JJ, Olivares-Alcolea, J, Arraiza-Irigoyen, C, Tejera-Perez, C, Martinez-Gonzalez, JD, Urioste-Fondo, A, Abad-Gonzalez, AL, Molina-Puerta, MJ, Zugasti-Murillo, A, Parra-Barona, J, Lopez-Cobo, I, Olveira, G
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
Repositorio:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
OAI Identifier:oai:isabial.fundanetsuite.com:p6733
Acceso en línea:https://isabial.portalinvestigacion.com/publicaciones6733
Access Level:acceso abierto
Palabra clave:parenteral nutrition
type 2 diabetes mellitus
polyunsaturated fatty acids
omega 3
hospital
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spelling Fish Oil Enriched Intravenous Lipid Emulsions Reduce Triglyceride Levels in Non-Critically Ill Patients with TPN and Type 2 Diabetes. A Post-Hoc Analysis of the INSUPAR StudyAbuin-Fernandez, JTapia-Guerrero, MJLopez-Urdiales, RHerranz-Antolin, SGarcia-Almeida, JMGarcia-Malpartida, KFerrer-Gomez, MCancer-Minchot, ELuengo-Perez, LMAlvarez-Hernandez, JValera, CAOcon-Breton, JGarcia-Manzanares, ABreton-Lesmes, ISerrano-Aguayo, PPerez-Ferre, NLopez-Gomez, JJOlivares-Alcolea, JArraiza-Irigoyen, CTejera-Perez, CMartinez-Gonzalez, JDUrioste-Fondo, AAbad-Gonzalez, ALMolina-Puerta, MJZugasti-Murillo, AParra-Barona, JLopez-Cobo, IOlveira, Gparenteral nutritiontype 2 diabetes mellituspolyunsaturated fatty acidsomega 3hospitalThere are no studies that have specifically assessed the role of intravenous lipid emulsions (ILE) enriched with fish oil in people with diabetes receiving total parenteral nutrition (TPN). The objective of this study was to assess the metabolic control (glycemic and lipid) and in-hospital complications that occurred in non-critically ill inpatients with TPN and type 2 diabetes with regard to the use of fish oil emulsions compared with other ILEs. We performed a post-hoc analysis of the Insulin in Parenteral Nutrition (INSUPAR) trial that included patients who started with TPN for any cause and that would predictably continue with TPN for at least five days. The study included 161 patients who started with TPN for any cause. There were 80 patients (49.7%) on fish oil enriched ILEs and 81 patients (50.3%) on other ILEs. We found significant decreases in triglyceride levels in the fish oil group compared to the other patients. We did not find any differences in glucose metabolic control: mean capillary glucose, glycemic variability, and insulin dose, except in the number of mild hypoglycemic events that was significantly higher in the fish oil group. We did not observe any differences in other metabolic, liver or infectious complications, in-hospital length of stay or mortality.MDPI2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://isabial.portalinvestigacion.com/publicaciones6733NutrientsISSN: 20726643reponame:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicanteinstname:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)Inglésinfo:eu-repo/semantics/openAccessoai:isabial.fundanetsuite.com:p67332026-06-12T10:20:37Z
dc.title.none.fl_str_mv Fish Oil Enriched Intravenous Lipid Emulsions Reduce Triglyceride Levels in Non-Critically Ill Patients with TPN and Type 2 Diabetes. A Post-Hoc Analysis of the INSUPAR Study
title Fish Oil Enriched Intravenous Lipid Emulsions Reduce Triglyceride Levels in Non-Critically Ill Patients with TPN and Type 2 Diabetes. A Post-Hoc Analysis of the INSUPAR Study
spellingShingle Fish Oil Enriched Intravenous Lipid Emulsions Reduce Triglyceride Levels in Non-Critically Ill Patients with TPN and Type 2 Diabetes. A Post-Hoc Analysis of the INSUPAR Study
Abuin-Fernandez, J
parenteral nutrition
type 2 diabetes mellitus
polyunsaturated fatty acids
omega 3
hospital
title_short Fish Oil Enriched Intravenous Lipid Emulsions Reduce Triglyceride Levels in Non-Critically Ill Patients with TPN and Type 2 Diabetes. A Post-Hoc Analysis of the INSUPAR Study
title_full Fish Oil Enriched Intravenous Lipid Emulsions Reduce Triglyceride Levels in Non-Critically Ill Patients with TPN and Type 2 Diabetes. A Post-Hoc Analysis of the INSUPAR Study
title_fullStr Fish Oil Enriched Intravenous Lipid Emulsions Reduce Triglyceride Levels in Non-Critically Ill Patients with TPN and Type 2 Diabetes. A Post-Hoc Analysis of the INSUPAR Study
title_full_unstemmed Fish Oil Enriched Intravenous Lipid Emulsions Reduce Triglyceride Levels in Non-Critically Ill Patients with TPN and Type 2 Diabetes. A Post-Hoc Analysis of the INSUPAR Study
title_sort Fish Oil Enriched Intravenous Lipid Emulsions Reduce Triglyceride Levels in Non-Critically Ill Patients with TPN and Type 2 Diabetes. A Post-Hoc Analysis of the INSUPAR Study
dc.creator.none.fl_str_mv Abuin-Fernandez, J
Tapia-Guerrero, MJ
Lopez-Urdiales, R
Herranz-Antolin, S
Garcia-Almeida, JM
Garcia-Malpartida, K
Ferrer-Gomez, M
Cancer-Minchot, E
Luengo-Perez, LM
Alvarez-Hernandez, J
Valera, CA
Ocon-Breton, J
Garcia-Manzanares, A
Breton-Lesmes, I
Serrano-Aguayo, P
Perez-Ferre, N
Lopez-Gomez, JJ
Olivares-Alcolea, J
Arraiza-Irigoyen, C
Tejera-Perez, C
Martinez-Gonzalez, JD
Urioste-Fondo, A
Abad-Gonzalez, AL
Molina-Puerta, MJ
Zugasti-Murillo, A
Parra-Barona, J
Lopez-Cobo, I
Olveira, G
author Abuin-Fernandez, J
author_facet Abuin-Fernandez, J
Tapia-Guerrero, MJ
Lopez-Urdiales, R
Herranz-Antolin, S
Garcia-Almeida, JM
Garcia-Malpartida, K
Ferrer-Gomez, M
Cancer-Minchot, E
Luengo-Perez, LM
Alvarez-Hernandez, J
Valera, CA
Ocon-Breton, J
Garcia-Manzanares, A
Breton-Lesmes, I
Serrano-Aguayo, P
Perez-Ferre, N
Lopez-Gomez, JJ
Olivares-Alcolea, J
Arraiza-Irigoyen, C
Tejera-Perez, C
Martinez-Gonzalez, JD
Urioste-Fondo, A
Abad-Gonzalez, AL
Molina-Puerta, MJ
Zugasti-Murillo, A
Parra-Barona, J
Lopez-Cobo, I
Olveira, G
author_role author
author2 Tapia-Guerrero, MJ
Lopez-Urdiales, R
Herranz-Antolin, S
Garcia-Almeida, JM
Garcia-Malpartida, K
Ferrer-Gomez, M
Cancer-Minchot, E
Luengo-Perez, LM
Alvarez-Hernandez, J
Valera, CA
Ocon-Breton, J
Garcia-Manzanares, A
Breton-Lesmes, I
Serrano-Aguayo, P
Perez-Ferre, N
Lopez-Gomez, JJ
Olivares-Alcolea, J
Arraiza-Irigoyen, C
Tejera-Perez, C
Martinez-Gonzalez, JD
Urioste-Fondo, A
Abad-Gonzalez, AL
Molina-Puerta, MJ
Zugasti-Murillo, A
Parra-Barona, J
Lopez-Cobo, I
Olveira, G
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv parenteral nutrition
type 2 diabetes mellitus
polyunsaturated fatty acids
omega 3
hospital
topic parenteral nutrition
type 2 diabetes mellitus
polyunsaturated fatty acids
omega 3
hospital
description There are no studies that have specifically assessed the role of intravenous lipid emulsions (ILE) enriched with fish oil in people with diabetes receiving total parenteral nutrition (TPN). The objective of this study was to assess the metabolic control (glycemic and lipid) and in-hospital complications that occurred in non-critically ill inpatients with TPN and type 2 diabetes with regard to the use of fish oil emulsions compared with other ILEs. We performed a post-hoc analysis of the Insulin in Parenteral Nutrition (INSUPAR) trial that included patients who started with TPN for any cause and that would predictably continue with TPN for at least five days. The study included 161 patients who started with TPN for any cause. There were 80 patients (49.7%) on fish oil enriched ILEs and 81 patients (50.3%) on other ILEs. We found significant decreases in triglyceride levels in the fish oil group compared to the other patients. We did not find any differences in glucose metabolic control: mean capillary glucose, glycemic variability, and insulin dose, except in the number of mild hypoglycemic events that was significantly higher in the fish oil group. We did not observe any differences in other metabolic, liver or infectious complications, in-hospital length of stay or mortality.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://isabial.portalinvestigacion.com/publicaciones6733
url https://isabial.portalinvestigacion.com/publicaciones6733
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Nutrients
ISSN: 20726643
reponame:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
instname:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
instname_str Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
reponame_str r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
collection r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812455

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