Fish Oil Enriched Intravenous Lipid Emulsions Reduce Triglyceride Levels in Non-Critically Ill Patients with TPN and Type 2 Diabetes. A Post-Hoc Analysis of the INSUPAR Study

There are no studies that have specifically assessed the role of intravenous lipid emulsions (ILE) enriched with fish oil in people with diabetes receiving total parenteral nutrition (TPN). The objective of this study was to assess the metabolic control (glycemic and lipid) and in-hospital complicat...

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Detalles Bibliográficos
Autores: Abuin-Fernandez, J, Tapia-Guerrero, MJ, Lopez-Urdiales, R, Herranz-Antolin, S, Garcia-Almeida, JM, Garcia-Malpartida, K, Ferrer-Gomez, M, Cancer-Minchot, E, Luengo-Perez, LM, Alvarez-Hernandez, J, Valera, CA, Ocon-Breton, J, Garcia-Manzanares, A, Breton-Lesmes, I, Serrano-Aguayo, P, Perez-Ferre, N, Lopez-Gomez, JJ, Olivares-Alcolea, J, Arraiza-Irigoyen, C, Tejera-Perez, C, Martinez-Gonzalez, JD, Urioste-Fondo, A, Abad-Gonzalez, AL, Molina-Puerta, MJ, Zugasti-Murillo, A, Parra-Barona, J, Lopez-Cobo, I, Olveira, G
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
Repositorio:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
OAI Identifier:oai:isabial.fundanetsuite.com:p6733
Acceso en línea:https://isabial.portalinvestigacion.com/publicaciones6733
Access Level:acceso abierto
Palabra clave:parenteral nutrition
type 2 diabetes mellitus
polyunsaturated fatty acids
omega 3
hospital
Descripción
Sumario:There are no studies that have specifically assessed the role of intravenous lipid emulsions (ILE) enriched with fish oil in people with diabetes receiving total parenteral nutrition (TPN). The objective of this study was to assess the metabolic control (glycemic and lipid) and in-hospital complications that occurred in non-critically ill inpatients with TPN and type 2 diabetes with regard to the use of fish oil emulsions compared with other ILEs. We performed a post-hoc analysis of the Insulin in Parenteral Nutrition (INSUPAR) trial that included patients who started with TPN for any cause and that would predictably continue with TPN for at least five days. The study included 161 patients who started with TPN for any cause. There were 80 patients (49.7%) on fish oil enriched ILEs and 81 patients (50.3%) on other ILEs. We found significant decreases in triglyceride levels in the fish oil group compared to the other patients. We did not find any differences in glucose metabolic control: mean capillary glucose, glycemic variability, and insulin dose, except in the number of mild hypoglycemic events that was significantly higher in the fish oil group. We did not observe any differences in other metabolic, liver or infectious complications, in-hospital length of stay or mortality.

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