A simple quantitative model of neuromodulation, part II: mechanosensitive channel gating
We develop a simple model of mechanosensitive channel gating of neuronal ion channels as a function of applied strain. The model considers channel gating as a two-state system obeying transition-state theory with an elastic bias introduced by the applied strain. Compelled by observations of electric...
| Autores: | , , , , , |
|---|---|
| Formato: | artículo |
| Fecha de publicación: | 2026 |
| País: | España |
| Recursos: | Universitat Politècnica de Catalunya (UPC) |
| Repositorio: | UPCommons. Portal del coneixement obert de la UPC |
| Idioma: | inglés |
| OAI Identifier: | oai:dnet:upcommonspor::6519de6802e744ae90eab55a34850acd |
| Acesso em linha: | https://hdl.handle.net/2117/461324 https://dx.doi.org/10.1016/j.jmps.2026.106609 |
| Access Level: | acceso abierto |
| Palavra-chave: | Mechanosensitive ion channels Action potential Mechanotransduction Àrees temàtiques de la UPC::Enginyeria biomèdica::Biomecànica |
| Resumo: | We develop a simple model of mechanosensitive channel gating of neuronal ion channels as a function of applied strain. The model considers channel gating as a two-state system obeying transition-state theory with an elastic bias introduced by the applied strain. Compelled by observations of electric signaling in human neurons, which evince a lack of time-sigmoidicity of the channel conductances and an ability of the membrane voltage to jump instantaneously upon application of a step current, we propose a resistor model of membrane signaling that departs from conventional capacitor models such as Hodgkin–Huxley. We validate the theory on the basis of an in-house testing program of human-derived immortalized neural cell line at applied various strains, combining calcium imaging integrated tension bioreactors under fluorescence microscopes with high-speed cameras. The ability of the theory to reproduce the experimentally observed action potentials is remarkable. |
|---|