Dual pH- and electro-responsive antibiotic-loaded polymeric platforms for effective bacterial detection and elimination

We describe a multi-tasking flexible system that is able to release a wide spectrum antibiotic (levofloxacin, LVX) under electrostimulation and act as a pH sensor for detecting bacterial infections. Combining anodic polymerization with plasma polymerization processes we engineered dual pH- and elect...

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Detalhes bibliográficos
Autores: Molina García, Brenda Guadalupe|||0000-0002-7723-5313, Vasani, Roshan Bharath, Jarvis, Karyn L., Armelín Diggroc, Elaine Aparecida|||0000-0002-0658-7696, Voelcker, Nicolas, Alemán Llansó, Carlos|||0000-0003-4462-6075
Formato: artículo
Fecha de publicación:2022
País:España
Recursos:Universitat Politècnica de Catalunya (UPC)
Repositorio:UPCommons. Portal del coneixement obert de la UPC
Idioma:inglés
OAI Identifier:oai:upcommons.upc.edu:2117/380361
Acesso em linha:https://hdl.handle.net/2117/380361
https://dx.doi.org/10.1016/j.reactfunctpolym.2022.105434
Access Level:acceso abierto
Palavra-chave:Conducting polymers
Drug delivery systems
Conducting polymer
Drug delivery
Electrostimulation
pH sensor
Poly(acrylic acid)
Polímers conductors
Medicaments--Modes d'administració
Àrees temàtiques de la UPC::Enginyeria química
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oai_identifier_str oai:upcommons.upc.edu:2117/380361
network_acronym_str ES
network_name_str España
repository_id_str
spelling Dual pH- and electro-responsive antibiotic-loaded polymeric platforms for effective bacterial detection and eliminationMolina García, Brenda Guadalupe|||0000-0002-7723-5313Vasani, Roshan BharathJarvis, Karyn L.Armelín Diggroc, Elaine Aparecida|||0000-0002-0658-7696Voelcker, NicolasAlemán Llansó, Carlos|||0000-0003-4462-6075Conducting polymersDrug delivery systemsConducting polymerDrug deliveryElectrostimulationpH sensorPoly(acrylic acid)Polímers conductorsMedicaments--Modes d'administracióÀrees temàtiques de la UPC::Enginyeria químicaWe describe a multi-tasking flexible system that is able to release a wide spectrum antibiotic (levofloxacin, LVX) under electrostimulation and act as a pH sensor for detecting bacterial infections. Combining anodic polymerization with plasma polymerization processes we engineered dual pH- and electro-responsive polymeric systems. Particularly, the manufactured devices consisted on a layer of poly(hydroxymethyl-3,4-ethylenedioxythiophene) (PHEDOT) loaded with the LVX antibiotic and coated with a plasma polymer layer of poly(acrylic acid) (PAA). The PHEDOT acted as conductive and electro-responsive agent, while the PAA provided pH responsiveness, changing from a compact globular conformation in acid environments to an expanded open coil conformation in alkaline environments. The assembly between the PHEDOT layer and the PAA coating affected the electrochemical response of the former, becoming dependent on the pH detected by the latter. The conformational change experienced by the PAA layer as a function of the pH and the redox properties of PHEDOT were leveraged for the electrochemical detection of bacteria growth and for regulating the release of the LVX antibiotic, respectively. The effectiveness of the system as a stimulus-responsive antibiotic carrier and pH sensor was also investigated on strains of Escherichia coli and Streptococcus salivarius.20222022-12-0120232023-01-12journal articlehttp://purl.org/coar/resource_type/c_6501AMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/2117/380361https://dx.doi.org/10.1016/j.reactfunctpolym.2022.105434reponame:UPCommons. Portal del coneixement obert de la UPCinstname:Universitat Politècnica de Catalunya (UPC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:upcommons.upc.edu:2117/3803612026-05-27T15:37:01Z
dc.title.none.fl_str_mv Dual pH- and electro-responsive antibiotic-loaded polymeric platforms for effective bacterial detection and elimination
title Dual pH- and electro-responsive antibiotic-loaded polymeric platforms for effective bacterial detection and elimination
spellingShingle Dual pH- and electro-responsive antibiotic-loaded polymeric platforms for effective bacterial detection and elimination
Molina García, Brenda Guadalupe|||0000-0002-7723-5313
Conducting polymers
Drug delivery systems
Conducting polymer
Drug delivery
Electrostimulation
pH sensor
Poly(acrylic acid)
Polímers conductors
Medicaments--Modes d'administració
Àrees temàtiques de la UPC::Enginyeria química
title_short Dual pH- and electro-responsive antibiotic-loaded polymeric platforms for effective bacterial detection and elimination
title_full Dual pH- and electro-responsive antibiotic-loaded polymeric platforms for effective bacterial detection and elimination
title_fullStr Dual pH- and electro-responsive antibiotic-loaded polymeric platforms for effective bacterial detection and elimination
title_full_unstemmed Dual pH- and electro-responsive antibiotic-loaded polymeric platforms for effective bacterial detection and elimination
title_sort Dual pH- and electro-responsive antibiotic-loaded polymeric platforms for effective bacterial detection and elimination
dc.creator.none.fl_str_mv Molina García, Brenda Guadalupe|||0000-0002-7723-5313
Vasani, Roshan Bharath
Jarvis, Karyn L.
Armelín Diggroc, Elaine Aparecida|||0000-0002-0658-7696
Voelcker, Nicolas
Alemán Llansó, Carlos|||0000-0003-4462-6075
author Molina García, Brenda Guadalupe|||0000-0002-7723-5313
author_facet Molina García, Brenda Guadalupe|||0000-0002-7723-5313
Vasani, Roshan Bharath
Jarvis, Karyn L.
Armelín Diggroc, Elaine Aparecida|||0000-0002-0658-7696
Voelcker, Nicolas
Alemán Llansó, Carlos|||0000-0003-4462-6075
author_role author
author2 Vasani, Roshan Bharath
Jarvis, Karyn L.
Armelín Diggroc, Elaine Aparecida|||0000-0002-0658-7696
Voelcker, Nicolas
Alemán Llansó, Carlos|||0000-0003-4462-6075
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Conducting polymers
Drug delivery systems
Conducting polymer
Drug delivery
Electrostimulation
pH sensor
Poly(acrylic acid)
Polímers conductors
Medicaments--Modes d'administració
Àrees temàtiques de la UPC::Enginyeria química
topic Conducting polymers
Drug delivery systems
Conducting polymer
Drug delivery
Electrostimulation
pH sensor
Poly(acrylic acid)
Polímers conductors
Medicaments--Modes d'administració
Àrees temàtiques de la UPC::Enginyeria química
description We describe a multi-tasking flexible system that is able to release a wide spectrum antibiotic (levofloxacin, LVX) under electrostimulation and act as a pH sensor for detecting bacterial infections. Combining anodic polymerization with plasma polymerization processes we engineered dual pH- and electro-responsive polymeric systems. Particularly, the manufactured devices consisted on a layer of poly(hydroxymethyl-3,4-ethylenedioxythiophene) (PHEDOT) loaded with the LVX antibiotic and coated with a plasma polymer layer of poly(acrylic acid) (PAA). The PHEDOT acted as conductive and electro-responsive agent, while the PAA provided pH responsiveness, changing from a compact globular conformation in acid environments to an expanded open coil conformation in alkaline environments. The assembly between the PHEDOT layer and the PAA coating affected the electrochemical response of the former, becoming dependent on the pH detected by the latter. The conformational change experienced by the PAA layer as a function of the pH and the redox properties of PHEDOT were leveraged for the electrochemical detection of bacteria growth and for regulating the release of the LVX antibiotic, respectively. The effectiveness of the system as a stimulus-responsive antibiotic carrier and pH sensor was also investigated on strains of Escherichia coli and Streptococcus salivarius.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-12-01
2023
2023-01-12
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
AM
http://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/2117/380361
https://dx.doi.org/10.1016/j.reactfunctpolym.2022.105434
url https://hdl.handle.net/2117/380361
https://dx.doi.org/10.1016/j.reactfunctpolym.2022.105434
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:UPCommons. Portal del coneixement obert de la UPC
instname:Universitat Politècnica de Catalunya (UPC)
instname_str Universitat Politècnica de Catalunya (UPC)
reponame_str UPCommons. Portal del coneixement obert de la UPC
collection UPCommons. Portal del coneixement obert de la UPC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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