Semiconducting, biodegradable and bioactive fibers for drug delivery

© BME-PT. In this work we present the drug release properties and morphological studies of fibers formed by mixing different ratios of poly(lactic acid) (PLA) and poly(3-thiophene methyl acetate) (P3TMA) loaded with four drugs (ciprofloxacin, chlorhexidine dihydrochloride, triclosan and ibuprofen so...

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Detalles Bibliográficos
Autores: Pérez Madrigal, Maria del Mar|||0000-0002-2498-8485, Llorens, Elena, Valle Mendoza, Luis Javier del|||0000-0001-9916-1741, Puiggalí Bellalta, Jordi|||0000-0002-0640-4474, Armelín Diggroc, Elaine Aparecida|||0000-0002-0658-7696, Alemán Llansó, Carlos|||0000-0003-4462-6075
Tipo de recurso: artículo
Fecha de publicación:2016
País:España
Institución:Universitat Politècnica de Catalunya (UPC)
Repositorio:UPCommons. Portal del coneixement obert de la UPC
Idioma:inglés
OAI Identifier:oai:upcommons.upc.edu:2117/89911
Acceso en línea:https://hdl.handle.net/2117/89911
https://dx.doi.org/10.3144/expresspolymlett.2016.58
Access Level:acceso abierto
Palabra clave:Biopolymers
Conducting polymers
Nanotechnology
Atomic force microscopy (AFM)
Biocomposites
Drug delivery systems
Polímers conductors
Biopolímers
Nanotecnologia
Àrees temàtiques de la UPC::Enginyeria química
Descripción
Sumario:© BME-PT. In this work we present the drug release properties and morphological studies of fibers formed by mixing different ratios of poly(lactic acid) (PLA) and poly(3-thiophene methyl acetate) (P3TMA) loaded with four drugs (ciprofloxacin, chlorhexidine dihydrochloride, triclosan and ibuprofen sodium salt). Thus, the main aim of this study is to prove that the excellent cellular response of PLA-P3TMA biocompatible scaffolds can be successfully combined with essential applications as drug carrier and delivery systems. Atomic force microscopic (AFM) and scanning electron microscopic (SEM) micro-graphs of PLA-P3TMA fibers indicate that the presence of the conducting polymer inside the PLA matrix affects the surface morphology, resulting in a significant increment of the bulk conductivity with respect to PLA fibers. Electrospun hybrid fibers of PLA and P3TMA successfully load both hydrophilic and hydrophobic drugs, the release profiles depending on the release environment (i.e. the release rate increases with the hydrophobicity of the medium). Finally, our results prove that the antibacterial activity of the drugs is not affected by their interactions with the PLA-P3TMA matrix.

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