Impact of Alzheimer's disease on sleep in adults with Down syndrome

INTRODUCTIONDown syndrome (DS) is a genetic form of Alzheimer's disease (AD), with a high prevalence of sleep disorders, but data in adults with DS and dementia are lacking. We aim to assess sleep in adults with DS across the AD continuum.METHODSWe studied 78 healthy controls and 229 adults wit...

Descripción completa

Detalles Bibliográficos
Autores: Giménez, S, Vaqué-Alcázar, L, Zhu, NL, Benejam, B, Arranz, J, Maure-Blesa, L, Videla, L, Carmona-Iragui, M, Barroeta, I, Rebillat, AS, Rodriguez-Baz, I, Bejanin, A, Arriola-Infante, JE, Bueno, A, Fernandez, S, Ribas, L, Zsadanyi, SE, Morcillo-Nieto, AO, Alcolea, D, Lisgaras, CP, Blessing, E, Osorio, RS, Lleo, A, Fortea, J
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositorio:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:iibsantpau.fundanetsuite.com:p20105
Acceso en línea:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=20105
Access Level:acceso abierto
Palabra clave:Alzheimer's disease
Down syndrome
obstructive sleep apnea
polysomnography
rapid eye movement sleep
sleep
slow-wave sleep
Descripción
Sumario:INTRODUCTIONDown syndrome (DS) is a genetic form of Alzheimer's disease (AD), with a high prevalence of sleep disorders, but data in adults with DS and dementia are lacking. We aim to assess sleep in adults with DS across the AD continuum.METHODSWe studied 78 healthy controls and 229 adults with DS (154 asymptomatic, 25 with prodromal AD, and 75 with AD) with subjective sleep measures and objective nocturnal polysomnography.RESULTSAdults with DS presented worse sleep quality and higher prevalence of unnoticed obstructive sleep apnea (OSA) than controls. Sleep disruption and OSA severity increased across the AD continuum. Age-related decreases in slow-wave sleep and rapid eye movement sleep were more pronounced in the DS group. Subjective sleep measures did not capture sleep disorders.CONCLUSIONSIn DS, AD is linked to worse sleep disturbances and altered architecture. However, longitudinal studies are needed to clarify directionality and disease progression.Highlights Down syndrome (DS) is associated with increased slow-wave sleep (SWS) and reduced rapid eye movement (REM) sleep. Obstructive sleep apnea prevalence increases along the Alzheimer's disease continuum in DS. Age-related decreases in SWS and REM sleep are accelerated in DS. Subjective sleep measures do not detect sleep disturbances in adults with DS.

Similares en LA Referencia