Impact of Alzheimer's disease on sleep in adults with Down syndrome

INTRODUCTION: Down syndrome (DS) is a genetic form of Alzheimer's disease (AD), with a high prevalence of sleep disorders, but data in adults with DS and dementia are lacking. We aim to assess sleep in adults with DS across the AD continuum. METHODS: We studied 78 healthy controls and 229 adult...

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Detalles Bibliográficos
Autores: Giménez, Sandra|||0000-0001-8031-2319, Vaqué-Alcázar, Lídia|||0000-0002-6776-6559, Zhu, Nuole|||0000-0002-0015-9455, Benejam, Bessy|||0000-0002-6789-8615, Arranz Martínez, Javier|||0000-0003-0891-1215, Maure Blesa, Lucia|||0000-0001-5643-7971, Videla Toro, Laura|||0000-0002-9748-8465, Carmona Iragui, Maria|||0000-0001-6914-2339, Barroeta, Isabel|||0000-0003-2764-7923, Rebillat, Anne-Sophie|||0000-0003-1995-9177, Rodríguez-Baz, Íñigo|||0000-0003-3039-9115, Bejanin, Alexandre|||0000-0002-9958-0951, Arriola Infante, José Enrique|||0000-0002-3298-4601, Bueno-López, Ana|||0000-0003-2390-219X, Fernández, Susana|||0000-0002-9777-1156, Ribas, Laia, Zsadanyi, Sara E.|||0000-0002-2033-5989, Morcillo-Nieto, Alejandra O.|||0000-0003-2202-3521, Alcolea, Daniel|||0000-0002-3819-3245, Lisgaras, Christos Panagiotis, Blessing, Esther, Osorio, Ricardo S., Lleó, Alberto|||0000-0002-2568-5478, Fortea, Juan|||0000-0002-1340-638X
Tipo de recurso: artículo
Fecha de publicación:2025
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:322275
Acceso en línea:https://ddd.uab.cat/record/322275
https://dx.doi.org/urn:doi:10.1002/alz.70400
Access Level:acceso abierto
Palabra clave:Alzheimer's disease
Down syndrome
Obstructive sleep apnea
Polysomnography
Rapid eye movement sleep
Sleep
Slow-wave sleep
Descripción
Sumario:INTRODUCTION: Down syndrome (DS) is a genetic form of Alzheimer's disease (AD), with a high prevalence of sleep disorders, but data in adults with DS and dementia are lacking. We aim to assess sleep in adults with DS across the AD continuum. METHODS: We studied 78 healthy controls and 229 adults with DS (154 asymptomatic, 25 with prodromal AD, and 75 with AD) with subjective sleep measures and objective nocturnal polysomnography. RESULTS: Adults with DS presented worse sleep quality and higher prevalence of unnoticed obstructive sleep apnea (OSA) than controls. Sleep disruption and OSA severity increased across the AD continuum. Age-related decreases in slow-wave sleep and rapid eye movement sleep were more pronounced in the DS group. Subjective sleep measures did not capture sleep disorders. CONCLUSIONS: In DS, AD is linked to worse sleep disturbances and altered architecture. However, longitudinal studies are needed to clarify directionality and disease progression. Highlights: Down syndrome (DS) is associated with increased slow-wave sleep (SWS) and reduced rapid eye movement (REM) sleep. Obstructive sleep apnea prevalence increases along the Alzheimer's disease continuum in DS. Age-related decreases in SWS and REM sleep are accelerated in DS. Subjective sleep measures do not detect sleep disturbances in adults with DS.

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