Sleep disorders in adults with down syndrome

Sleep disorders, despite being very frequent in adults with Down syndrome (DS), are often overlooked due to a lack of awareness by families and physicians and the absence of specific clinical sleep guidelines. Untreated sleep disorders have a negative impact on physical and mental health, behavior,...

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Detalles Bibliográficos
Autores: Giménez, Sandra|||0000-0001-8031-2319, Altuna-Azkargorta, Miren|||0000-0001-9709-5314, Blessing, Esther, Osorio, Ricardo M., Fortea, Juan|||0000-0002-1340-638X
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:269706
Acceso en línea:https://ddd.uab.cat/record/269706
https://dx.doi.org/urn:doi:10.3390/jcm10143012
Access Level:acceso abierto
Palabra clave:Down syndrome
Aging
Sleep disorders
Obstructive sleep apnea
Insomnia
Alzheimer's disease
Descripción
Sumario:Sleep disorders, despite being very frequent in adults with Down syndrome (DS), are often overlooked due to a lack of awareness by families and physicians and the absence of specific clinical sleep guidelines. Untreated sleep disorders have a negative impact on physical and mental health, behavior, and cognitive performance. Growing evidence suggests that sleep disruption may also accelerate the progression to symptomatic Alzheimer's disease (AD) in this population. It is therefore imperative to have a better understanding of the sleep disorders associated with DS in order to treat them, and in doing so, improve cognition and quality of life, and prevent related comorbidities. This paper reviews the current knowledge of the main sleep disorders in adults with DS, including evaluation and management. It highlights the existing gaps in knowledge and discusses future directions to achieve earlier diagnosis and better treatment of sleep disorders most frequently found in this population.