Non-covalent hydrogels of cyclodextrins and poloxamines for the controlled release of proteins

Different types of gels were prepared by combining poloxamines (Tetronic), i.e. poly(ethylene oxide)/poly(propylene oxide) (PEO/PPO) octablock star copolymers, and cyclodextrins (CD). Two different poloxamines with the same molecular weight (ca. 7000) but different molecular architectures were used....

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Detalles Bibliográficos
Autores: Larrañeta, E. (Eneko)|||/items/dfeb2f8f-aa42-45ef-82fe-d61110bb0166, Isasi-Allica, J.R. (José Ramón)|||/items/75140f94-5739-4e6a-b40c-be14e579a64c
Tipo de recurso: artículo
Fecha de publicación:2014
País:España
Institución:Universidad de Navarra
Repositorio:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglés
OAI Identifier:oai:dadun.unav.edu:10171/40062
Acceso en línea:https://hdl.handle.net/10171/40062
Access Level:acceso abierto
Palabra clave:Non-Covalent Hydrogels
Cyclodextrins
Poloxamines
Proteins
Materias Investigacion::Química
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spelling Non-covalent hydrogels of cyclodextrins and poloxamines for the controlled release of proteinsLarrañeta, E. (Eneko)|||/items/dfeb2f8f-aa42-45ef-82fe-d61110bb0166Isasi-Allica, J.R. (José Ramón)|||/items/75140f94-5739-4e6a-b40c-be14e579a64cNon-Covalent HydrogelsCyclodextrinsPoloxaminesProteinsMaterias Investigacion::QuímicaDifferent types of gels were prepared by combining poloxamines (Tetronic), i.e. poly(ethylene oxide)/poly(propylene oxide) (PEO/PPO) octablock star copolymers, and cyclodextrins (CD). Two different poloxamines with the same molecular weight (ca. 7000) but different molecular architectures were used. For each of their four diblock arms, direct Tetronic 904 presents PEO outer blocks while in reverse Tetronic 90R4 the hydrophilic PEO blocks are the inner ones. These gels were prepared by combining α-CD and poloxamine aqueous solutions. The physicochemical properties of these systems depend on several factors such as the structure of the block copolymers and the Tetronic/α-CD ratio. These gels were characterized using differential scanning calorimetry (DSC), viscometry and X-ray diffraction measurements. The 90R4 gels present a consistency that makes them suitable for sustained drug delivery. The resulting gels were easily eroded: these complexes were dismantled when placed in a large amount of water, so controlled release of entrapped large molecules such as proteins (Bovine Serum Albumin, BSA) is feasible and can be tuned by varying the copolymer/CD ratio.ElsevierDadun. Depósito Académico Digital Universidad de Navarra20162016-02-2720142014-01-0120142014-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/40062reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/400622026-06-21T12:47:57Z
dc.title.none.fl_str_mv Non-covalent hydrogels of cyclodextrins and poloxamines for the controlled release of proteins
title Non-covalent hydrogels of cyclodextrins and poloxamines for the controlled release of proteins
spellingShingle Non-covalent hydrogels of cyclodextrins and poloxamines for the controlled release of proteins
Larrañeta, E. (Eneko)|||/items/dfeb2f8f-aa42-45ef-82fe-d61110bb0166
Non-Covalent Hydrogels
Cyclodextrins
Poloxamines
Proteins
Materias Investigacion::Química
title_short Non-covalent hydrogels of cyclodextrins and poloxamines for the controlled release of proteins
title_full Non-covalent hydrogels of cyclodextrins and poloxamines for the controlled release of proteins
title_fullStr Non-covalent hydrogels of cyclodextrins and poloxamines for the controlled release of proteins
title_full_unstemmed Non-covalent hydrogels of cyclodextrins and poloxamines for the controlled release of proteins
title_sort Non-covalent hydrogels of cyclodextrins and poloxamines for the controlled release of proteins
dc.creator.none.fl_str_mv Larrañeta, E. (Eneko)|||/items/dfeb2f8f-aa42-45ef-82fe-d61110bb0166
Isasi-Allica, J.R. (José Ramón)|||/items/75140f94-5739-4e6a-b40c-be14e579a64c
author Larrañeta, E. (Eneko)|||/items/dfeb2f8f-aa42-45ef-82fe-d61110bb0166
author_facet Larrañeta, E. (Eneko)|||/items/dfeb2f8f-aa42-45ef-82fe-d61110bb0166
Isasi-Allica, J.R. (José Ramón)|||/items/75140f94-5739-4e6a-b40c-be14e579a64c
author_role author
author2 Isasi-Allica, J.R. (José Ramón)|||/items/75140f94-5739-4e6a-b40c-be14e579a64c
author2_role author
dc.contributor.none.fl_str_mv Dadun. Depósito Académico Digital Universidad de Navarra
dc.subject.none.fl_str_mv Non-Covalent Hydrogels
Cyclodextrins
Poloxamines
Proteins
Materias Investigacion::Química
topic Non-Covalent Hydrogels
Cyclodextrins
Poloxamines
Proteins
Materias Investigacion::Química
description Different types of gels were prepared by combining poloxamines (Tetronic), i.e. poly(ethylene oxide)/poly(propylene oxide) (PEO/PPO) octablock star copolymers, and cyclodextrins (CD). Two different poloxamines with the same molecular weight (ca. 7000) but different molecular architectures were used. For each of their four diblock arms, direct Tetronic 904 presents PEO outer blocks while in reverse Tetronic 90R4 the hydrophilic PEO blocks are the inner ones. These gels were prepared by combining α-CD and poloxamine aqueous solutions. The physicochemical properties of these systems depend on several factors such as the structure of the block copolymers and the Tetronic/α-CD ratio. These gels were characterized using differential scanning calorimetry (DSC), viscometry and X-ray diffraction measurements. The 90R4 gels present a consistency that makes them suitable for sustained drug delivery. The resulting gels were easily eroded: these complexes were dismantled when placed in a large amount of water, so controlled release of entrapped large molecules such as proteins (Bovine Serum Albumin, BSA) is feasible and can be tuned by varying the copolymer/CD ratio.
publishDate 2014
dc.date.none.fl_str_mv 2014
2014-01-01
2014
2014-01-01
2016
2016-02-27
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10171/40062
url https://hdl.handle.net/10171/40062
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra
instname:Universidad de Navarra
instname_str Universidad de Navarra
reponame_str Dadun. Depósito Académico Digital de la Universidad de Navarra
collection Dadun. Depósito Académico Digital de la Universidad de Navarra
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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