Preparation, characterization and evaluation of the anti-inflammatory activity of epichlorohydrin-β-cyclodextrin/curcumin binary systems embedded in a pluronic® /hyaluronate hydrogel

Curcumin (Cur) is an anti-inflammatory polyphenol that can be complexed with polymeric cyclodextrin (CD) to improve solubility and bioavailability. The aim of the present work was to prepare a CurCD hydrogel to treat inflammatory skin conditions. Epichlorohydrin-β-CD (EpiβCD) was used as polymeric C...

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Bibliographic Details
Authors: Fernández Romero, Ana María, Maestrelli, Francesca, García Gil, Sara, Talero Barrientos, Elena Mª, Mura, Paola Angela, Rabasco Álvarez, Antonio María, González Rodríguez, María Luisa
Format: article
Status:Published version
Publication Date:2021
Country:España
Institution:Universidad de Sevilla (US)
Repository:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/137925
Online Access:https://hdl.handle.net/11441/137925
https://doi.org/10.3390/ijms222413566
Access Level:Open access
Keyword:Curcumin
Cyclodextrin
Epichlorohydrin-β-cyclodextrin
Hydrogel
Inflammatory disease
Pluronic
Psoriasis
Description
Summary:Curcumin (Cur) is an anti-inflammatory polyphenol that can be complexed with polymeric cyclodextrin (CD) to improve solubility and bioavailability. The aim of the present work was to prepare a CurCD hydrogel to treat inflammatory skin conditions. Epichlorohydrin-β-CD (EpiβCD) was used as polymeric CD. To characterize the binary system, solid-state and in-solution studies were performed. Afterwards, an experimental design was performed to optimize the hy-drogel system. Finally, the CurEpiβCD hydrogel system was tested for anti-inflammatory activity using a HaCat psoriasis cell model. Co-grinded Cur/EpiβCD binary system showed a strong interaction and Curcumin solubility was much improved. Its combination with Pluronic® F-127/hyalu-ronate hydrogel demonstrated an improvement in release rate and Curcumin permeation. After testing its anti-inflammatory activity, the system showed a significant reduction in IL-6 levels. Hy-drogel-containing CurEpiβCD complex is a great alternative to treat topical inflammatory diseases.

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