Lost in mTORC1-related translation limits healing, repair and regeneration in mammals

Wound healing is a coordinated process that can be divided into three general phases: inflammatory processes, tissue formation and tissue remodeling. The molecular and cellular events involved in healing, repair and regeneration are still poorly understood, and current therapies are limited. As a re...

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Detalles Bibliográficos
Autor: Izquierdo, José M.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/344025
Acceso en línea:http://hdl.handle.net/10261/344025
Access Level:acceso abierto
Palabra clave:mTORC1
De novo translation
Wound healing
Repair
Regeneration
Regenerative medicine
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spelling Lost in mTORC1-related translation limits healing, repair and regeneration in mammalsIzquierdo, José M.mTORC1De novo translationWound healingRepairRegenerationRegenerative medicineWound healing is a coordinated process that can be divided into three general phases: inflammatory processes, tissue formation and tissue remodeling. The molecular and cellular events involved in healing, repair and regeneration are still poorly understood, and current therapies are limited. As a result, defective wound healing affects millions of people worldwide every year. Beyond the current wound healing dogma, new mediators and regulatory nodes are continuously being discovered, opening new therapeutic avenues (Wilkinson and Hardman, 2020).The author(s) declare financial support was received for the research, authorship, and/or publication of this article. Research in the author’s laboratory is supported by the Ministry of Science and Innovation and the Spanish Research Agency through FEDER funds (PID 2021-1261520B-100) (MICINN/AEI/FEDER, EU). CBMSO receives an institutional grant from the Fundación Ramón Areces, Spain.Peer reviewedFrontiers MediaMinisterio de Ciencia e Innovación (España)European CommissionAgencia Estatal de Investigación (España)Fundación Ramón ArecesConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202420242023info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/344025reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2021-126152OB-I00https://doi.org/10.3389/fcell.2023.1294934Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3440252026-05-22T06:33:51Z
dc.title.none.fl_str_mv Lost in mTORC1-related translation limits healing, repair and regeneration in mammals
title Lost in mTORC1-related translation limits healing, repair and regeneration in mammals
spellingShingle Lost in mTORC1-related translation limits healing, repair and regeneration in mammals
Izquierdo, José M.
mTORC1
De novo translation
Wound healing
Repair
Regeneration
Regenerative medicine
title_short Lost in mTORC1-related translation limits healing, repair and regeneration in mammals
title_full Lost in mTORC1-related translation limits healing, repair and regeneration in mammals
title_fullStr Lost in mTORC1-related translation limits healing, repair and regeneration in mammals
title_full_unstemmed Lost in mTORC1-related translation limits healing, repair and regeneration in mammals
title_sort Lost in mTORC1-related translation limits healing, repair and regeneration in mammals
dc.creator.none.fl_str_mv Izquierdo, José M.
author Izquierdo, José M.
author_facet Izquierdo, José M.
author_role author
dc.contributor.none.fl_str_mv Ministerio de Ciencia e Innovación (España)
European Commission
Agencia Estatal de Investigación (España)
Fundación Ramón Areces
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv mTORC1
De novo translation
Wound healing
Repair
Regeneration
Regenerative medicine
topic mTORC1
De novo translation
Wound healing
Repair
Regeneration
Regenerative medicine
description Wound healing is a coordinated process that can be divided into three general phases: inflammatory processes, tissue formation and tissue remodeling. The molecular and cellular events involved in healing, repair and regeneration are still poorly understood, and current therapies are limited. As a result, defective wound healing affects millions of people worldwide every year. Beyond the current wound healing dogma, new mediators and regulatory nodes are continuously being discovered, opening new therapeutic avenues (Wilkinson and Hardman, 2020).
publishDate 2023
dc.date.none.fl_str_mv 2023
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/344025
url http://hdl.handle.net/10261/344025
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2021-126152OB-I00
https://doi.org/10.3389/fcell.2023.1294934
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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