Impact of T Cell Dose on Outcome of T Cell-Replete HLA-Matched Allogeneic Peripheral Blood Stem Cell Transplantation

Saad, Ayman|||0000-0003-0003-0130; Lamb, Lawrence|||0000-0001-7180-0994; Wang, Tao|||0000-0002-1323-8697; Hemmer, Michael T.; Spellman, Stephen|||0000-0002-7271-8252; Couriel, Daniel R.|||0000-0001-8167-4282; Alousi, Amin; Pidala, Joseph; Abdel-Azim, Hisham; Agrawal, Vaibhav|||0000-0002-6383-3777; Aljurf, Mahmoud|||0000-0003-3942-7370; Beitinjaneh, Amer|||0000-0002-1661-5865; Bhatt, Vijaya Raj|||0000-0003-2513-0533; Buchbinder, David Kyle; Byrne, Michael; Cahn, Jean-Yves; Cairo, Mitchell S.; Castillo, Paul A.; Chhabra, Saurabh|||0000-0001-9117-8696; Diaz, Miguel Angel; Farhan, Shatha|||0000-0002-5723-7442; Floisand, Yngvar|||0000-0001-7267-1944; Frangoul, Haydar A.; Gadalla, Shahinaz M.|||0000-0002-3255-8143; Gajewski, James; Gale, Robert Peter|||0000-0002-9156-1676; Gandhi, Manish; Gergis, Usama|||0000-0003-0656-7385; Hamilton, Betty|||0000-0003-1252-6539; Hematti, Peiman|||0000-0001-5836-4497; Hildebrandt, Gerhard C.; Kamble, Rammurti T.; Kanate, Abraham S.; Khandelwal, Pooja; Lazaryn, Aleksandr; MacMillan, Margaret|||0000-0002-0755-0852; Marks, David I.; Martino Bofarull, Rodrigo|||0000-0001-5143-4042; Mehta, Parinda A.; Nishihori, Taiga|||0000-0002-2621-7924; Olsson, Richard|||0000-0001-5970-2128; Patel, Sagar|||0000-0001-9949-3615; Qayed, Muna|||0000-0001-7689-343X; Rangarajan, Hemalatha G.; Reshef, R.; Ringden, Olle|||0000-0002-6092-1536; Savani, Bipin|||0000-0002-3304-9965; Schouten, H.C.; Schultz, K.R.; Seo, Sachiko|||0000-0002-4308-2152; Shaffer, B.C.; Solh, M.; Teshima, T.; Urbano Ispizua, Álvaro|||0000-0002-7529-9399; Verdonck, L.F.; Vij, R.; Waller, Edmund K.|||0000-0003-0816-6729; William, Basem; Wirk, Baldeep Mona; Yared, Jean A.; Yu, L.C.; Arora, Mukta|||0000-0001-9362-0556; Hashmi, S.

Impact of T Cell Dose on Outcome of T Cell-Replete HLA-Matched Allogeneic Peripheral Blood Stem Cell Transplantation

Data on whether the T cell dose of allogeneic peripheral blood stem cell (PBSC) products influences transplantation outcomes are conflicting. Using the Center for International Blood and Marrow Transplant Research database, we identified 2736 adult patients who underwent first allogeneic PBSC transp...

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Autores:	Saad, Ayman\|\|\|0000-0003-0003-0130, Lamb, Lawrence\|\|\|0000-0001-7180-0994, Wang, Tao\|\|\|0000-0002-1323-8697, Hemmer, Michael T., Spellman, Stephen\|\|\|0000-0002-7271-8252, Couriel, Daniel R.\|\|\|0000-0001-8167-4282, Alousi, Amin, Pidala, Joseph, Abdel-Azim, Hisham, Agrawal, Vaibhav\|\|\|0000-0002-6383-3777, Aljurf, Mahmoud\|\|\|0000-0003-3942-7370, Beitinjaneh, Amer\|\|\|0000-0002-1661-5865, Bhatt, Vijaya Raj\|\|\|0000-0003-2513-0533, Buchbinder, David Kyle, Byrne, Michael, Cahn, Jean-Yves, Cairo, Mitchell S., Castillo, Paul A., Chhabra, Saurabh\|\|\|0000-0001-9117-8696, Diaz, Miguel Angel, Farhan, Shatha\|\|\|0000-0002-5723-7442, Floisand, Yngvar\|\|\|0000-0001-7267-1944, Frangoul, Haydar A., Gadalla, Shahinaz M.\|\|\|0000-0002-3255-8143, Gajewski, James, Gale, Robert Peter\|\|\|0000-0002-9156-1676, Gandhi, Manish, Gergis, Usama\|\|\|0000-0003-0656-7385, Hamilton, Betty\|\|\|0000-0003-1252-6539, Hematti, Peiman\|\|\|0000-0001-5836-4497, Hildebrandt, Gerhard C., Kamble, Rammurti T., Kanate, Abraham S., Khandelwal, Pooja, Lazaryn, Aleksandr, MacMillan, Margaret\|\|\|0000-0002-0755-0852, Marks, David I., Martino Bofarull, Rodrigo\|\|\|0000-0001-5143-4042, Mehta, Parinda A., Nishihori, Taiga\|\|\|0000-0002-2621-7924, Olsson, Richard\|\|\|0000-0001-5970-2128, Patel, Sagar\|\|\|0000-0001-9949-3615, Qayed, Muna\|\|\|0000-0001-7689-343X, Rangarajan, Hemalatha G., Reshef, R., Ringden, Olle\|\|\|0000-0002-6092-1536, Savani, Bipin\|\|\|0000-0002-3304-9965, Schouten, H.C., Schultz, K.R., Seo, Sachiko\|\|\|0000-0002-4308-2152, Shaffer, B.C., Solh, M., Teshima, T., Urbano Ispizua, Álvaro\|\|\|0000-0002-7529-9399, Verdonck, L.F., Vij, R., Waller, Edmund K.\|\|\|0000-0003-0816-6729, William, Basem, Wirk, Baldeep Mona, Yared, Jean A., Yu, L.C., Arora, Mukta\|\|\|0000-0001-9362-0556, Hashmi, S.
Tipo de recurso:	artículo
Fecha de publicación:	2019
País:	España
Institución:	Universitat Autònoma de Barcelona
Repositorio:	Dipòsit Digital de Documents de la UAB
Idioma:	inglés
OAI Identifier:	oai:ddd.uab.cat:286452
Acceso en línea:	https://ddd.uab.cat/record/286452 https://dx.doi.org/urn:doi:10.1016/j.bbmt.2019.05.007
Access Level:	acceso abierto
Palabra clave:	Allogeneic GVHD dose T cell Transplantation

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oai_identifier_str	oai:ddd.uab.cat:286452
network_acronym_str	ES
network_name_str	España
repository_id_str
dc.title.none.fl_str_mv	Impact of T Cell Dose on Outcome of T Cell-Replete HLA-Matched Allogeneic Peripheral Blood Stem Cell Transplantation
title	Impact of T Cell Dose on Outcome of T Cell-Replete HLA-Matched Allogeneic Peripheral Blood Stem Cell Transplantation
spellingShingle	Impact of T Cell Dose on Outcome of T Cell-Replete HLA-Matched Allogeneic Peripheral Blood Stem Cell Transplantation Saad, Ayman\|\|\|0000-0003-0003-0130 Allogeneic GVHD dose T cell Transplantation
title_short	Impact of T Cell Dose on Outcome of T Cell-Replete HLA-Matched Allogeneic Peripheral Blood Stem Cell Transplantation
title_full	Impact of T Cell Dose on Outcome of T Cell-Replete HLA-Matched Allogeneic Peripheral Blood Stem Cell Transplantation
title_fullStr	Impact of T Cell Dose on Outcome of T Cell-Replete HLA-Matched Allogeneic Peripheral Blood Stem Cell Transplantation
title_full_unstemmed	Impact of T Cell Dose on Outcome of T Cell-Replete HLA-Matched Allogeneic Peripheral Blood Stem Cell Transplantation
title_sort	Impact of T Cell Dose on Outcome of T Cell-Replete HLA-Matched Allogeneic Peripheral Blood Stem Cell Transplantation
dc.creator.none.fl_str_mv	Saad, Ayman\|\|\|0000-0003-0003-0130 Lamb, Lawrence\|\|\|0000-0001-7180-0994 Wang, Tao\|\|\|0000-0002-1323-8697 Hemmer, Michael T. Spellman, Stephen\|\|\|0000-0002-7271-8252 Couriel, Daniel R.\|\|\|0000-0001-8167-4282 Alousi, Amin Pidala, Joseph Abdel-Azim, Hisham Agrawal, Vaibhav\|\|\|0000-0002-6383-3777 Aljurf, Mahmoud\|\|\|0000-0003-3942-7370 Beitinjaneh, Amer\|\|\|0000-0002-1661-5865 Bhatt, Vijaya Raj\|\|\|0000-0003-2513-0533 Buchbinder, David Kyle Byrne, Michael Cahn, Jean-Yves Cairo, Mitchell S. Castillo, Paul A. Chhabra, Saurabh\|\|\|0000-0001-9117-8696 Diaz, Miguel Angel Farhan, Shatha\|\|\|0000-0002-5723-7442 Floisand, Yngvar\|\|\|0000-0001-7267-1944 Frangoul, Haydar A. Gadalla, Shahinaz M.\|\|\|0000-0002-3255-8143 Gajewski, James Gale, Robert Peter\|\|\|0000-0002-9156-1676 Gandhi, Manish Gergis, Usama\|\|\|0000-0003-0656-7385 Hamilton, Betty\|\|\|0000-0003-1252-6539 Hematti, Peiman\|\|\|0000-0001-5836-4497 Hildebrandt, Gerhard C. Kamble, Rammurti T. Kanate, Abraham S. Khandelwal, Pooja Lazaryn, Aleksandr MacMillan, Margaret\|\|\|0000-0002-0755-0852 Marks, David I. Martino Bofarull, Rodrigo\|\|\|0000-0001-5143-4042 Mehta, Parinda A. Nishihori, Taiga\|\|\|0000-0002-2621-7924 Olsson, Richard\|\|\|0000-0001-5970-2128 Patel, Sagar\|\|\|0000-0001-9949-3615 Qayed, Muna\|\|\|0000-0001-7689-343X Rangarajan, Hemalatha G. Reshef, R. Ringden, Olle\|\|\|0000-0002-6092-1536 Savani, Bipin\|\|\|0000-0002-3304-9965 Schouten, H.C. Schultz, K.R. Seo, Sachiko\|\|\|0000-0002-4308-2152 Shaffer, B.C. Solh, M. Teshima, T. Urbano Ispizua, Álvaro\|\|\|0000-0002-7529-9399 Verdonck, L.F. Vij, R. Waller, Edmund K.\|\|\|0000-0003-0816-6729 William, Basem Wirk, Baldeep Mona Yared, Jean A. Yu, L.C. Arora, Mukta\|\|\|0000-0001-9362-0556 Hashmi, S.
author	Saad, Ayman\|\|\|0000-0003-0003-0130
author_facet	Saad, Ayman\|\|\|0000-0003-0003-0130 Lamb, Lawrence\|\|\|0000-0001-7180-0994 Wang, Tao\|\|\|0000-0002-1323-8697 Hemmer, Michael T. Spellman, Stephen\|\|\|0000-0002-7271-8252 Couriel, Daniel R.\|\|\|0000-0001-8167-4282 Alousi, Amin Pidala, Joseph Abdel-Azim, Hisham Agrawal, Vaibhav\|\|\|0000-0002-6383-3777 Aljurf, Mahmoud\|\|\|0000-0003-3942-7370 Beitinjaneh, Amer\|\|\|0000-0002-1661-5865 Bhatt, Vijaya Raj\|\|\|0000-0003-2513-0533 Buchbinder, David Kyle Byrne, Michael Cahn, Jean-Yves Cairo, Mitchell S. Castillo, Paul A. Chhabra, Saurabh\|\|\|0000-0001-9117-8696 Diaz, Miguel Angel Farhan, Shatha\|\|\|0000-0002-5723-7442 Floisand, Yngvar\|\|\|0000-0001-7267-1944 Frangoul, Haydar A. Gadalla, Shahinaz M.\|\|\|0000-0002-3255-8143 Gajewski, James Gale, Robert Peter\|\|\|0000-0002-9156-1676 Gandhi, Manish Gergis, Usama\|\|\|0000-0003-0656-7385 Hamilton, Betty\|\|\|0000-0003-1252-6539 Hematti, Peiman\|\|\|0000-0001-5836-4497 Hildebrandt, Gerhard C. Kamble, Rammurti T. Kanate, Abraham S. Khandelwal, Pooja Lazaryn, Aleksandr MacMillan, Margaret\|\|\|0000-0002-0755-0852 Marks, David I. Martino Bofarull, Rodrigo\|\|\|0000-0001-5143-4042 Mehta, Parinda A. Nishihori, Taiga\|\|\|0000-0002-2621-7924 Olsson, Richard\|\|\|0000-0001-5970-2128 Patel, Sagar\|\|\|0000-0001-9949-3615 Qayed, Muna\|\|\|0000-0001-7689-343X Rangarajan, Hemalatha G. Reshef, R. Ringden, Olle\|\|\|0000-0002-6092-1536 Savani, Bipin\|\|\|0000-0002-3304-9965 Schouten, H.C. Schultz, K.R. Seo, Sachiko\|\|\|0000-0002-4308-2152 Shaffer, B.C. Solh, M. Teshima, T. Urbano Ispizua, Álvaro\|\|\|0000-0002-7529-9399 Verdonck, L.F. Vij, R. Waller, Edmund K.\|\|\|0000-0003-0816-6729 William, Basem Wirk, Baldeep Mona Yared, Jean A. Yu, L.C. Arora, Mukta\|\|\|0000-0001-9362-0556 Hashmi, S.
author_role	author
author2	Lamb, Lawrence\|\|\|0000-0001-7180-0994 Wang, Tao\|\|\|0000-0002-1323-8697 Hemmer, Michael T. Spellman, Stephen\|\|\|0000-0002-7271-8252 Couriel, Daniel R.\|\|\|0000-0001-8167-4282 Alousi, Amin Pidala, Joseph Abdel-Azim, Hisham Agrawal, Vaibhav\|\|\|0000-0002-6383-3777 Aljurf, Mahmoud\|\|\|0000-0003-3942-7370 Beitinjaneh, Amer\|\|\|0000-0002-1661-5865 Bhatt, Vijaya Raj\|\|\|0000-0003-2513-0533 Buchbinder, David Kyle Byrne, Michael Cahn, Jean-Yves Cairo, Mitchell S. Castillo, Paul A. Chhabra, Saurabh\|\|\|0000-0001-9117-8696 Diaz, Miguel Angel Farhan, Shatha\|\|\|0000-0002-5723-7442 Floisand, Yngvar\|\|\|0000-0001-7267-1944 Frangoul, Haydar A. Gadalla, Shahinaz M.\|\|\|0000-0002-3255-8143 Gajewski, James Gale, Robert Peter\|\|\|0000-0002-9156-1676 Gandhi, Manish Gergis, Usama\|\|\|0000-0003-0656-7385 Hamilton, Betty\|\|\|0000-0003-1252-6539 Hematti, Peiman\|\|\|0000-0001-5836-4497 Hildebrandt, Gerhard C. Kamble, Rammurti T. Kanate, Abraham S. Khandelwal, Pooja Lazaryn, Aleksandr MacMillan, Margaret\|\|\|0000-0002-0755-0852 Marks, David I. Martino Bofarull, Rodrigo\|\|\|0000-0001-5143-4042 Mehta, Parinda A. Nishihori, Taiga\|\|\|0000-0002-2621-7924 Olsson, Richard\|\|\|0000-0001-5970-2128 Patel, Sagar\|\|\|0000-0001-9949-3615 Qayed, Muna\|\|\|0000-0001-7689-343X Rangarajan, Hemalatha G. Reshef, R. Ringden, Olle\|\|\|0000-0002-6092-1536 Savani, Bipin\|\|\|0000-0002-3304-9965 Schouten, H.C. Schultz, K.R. Seo, Sachiko\|\|\|0000-0002-4308-2152 Shaffer, B.C. Solh, M. Teshima, T. Urbano Ispizua, Álvaro\|\|\|0000-0002-7529-9399 Verdonck, L.F. Vij, R. Waller, Edmund K.\|\|\|0000-0003-0816-6729 William, Basem Wirk, Baldeep Mona Yared, Jean A. Yu, L.C. Arora, Mukta\|\|\|0000-0001-9362-0556 Hashmi, S.
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.contributor.none.fl_str_mv	Universitat Autònoma de Barcelona
dc.subject.none.fl_str_mv	Allogeneic GVHD dose T cell Transplantation
topic	Allogeneic GVHD dose T cell Transplantation
description	Data on whether the T cell dose of allogeneic peripheral blood stem cell (PBSC) products influences transplantation outcomes are conflicting. Using the Center for International Blood and Marrow Transplant Research database, we identified 2736 adult patients who underwent first allogeneic PBSC transplantation for acute leukemia or myelodysplastic syndrome between 2008 and 2014 using an HLA-matched sibling donor (MSD) or an 8/8-matched unrelated donor (MUD). We excluded ex vivo and in vivo T cell-depleted transplantations. Correlative analysis was performed between CD3 T cell dose and the risk of graft-versus-host-disease (GVHD), relapse, nonrelapse mortality (NRM), disease-free survival (DFS), and overall survival (OS). Using maximum likelihood estimation, we identified CD3 T cell dose cutoff that separated the risk of acute GVHD (aGVHD) grade II-IV in both the MSD and MUD groups. A CD3 T cell dose cutoff of 14 × 10 cells/kg identified MSD/low CD3 (n = 223) and MSD/high CD3 (n = 1214), and a dose of 15 × 10 cells/kg identified MUD/low CD3 (n = 197) and MUD/high CD3 (n = 1102). On univariate analysis, the MSD/high CD3 group had a higher cumulative incidence of day +100 aGVHD grade II-IV compared with the MSD/low CD3 group (33% versus 25%; P =.009). There were no differences between the 2 groups in engraftment rate, risk of aGVHD grade III-IV or chronic GVHD (cGVHD), NRM, relapse, DFS, or OS. The MUD/high CD3 group had a higher cumulative incidence of day +100 aGVHD grade II-IV compared with the MUD/low CD3 group (49% versus 41%; P =.04). There were no differences between the 2 groups in engraftment rate, risk of severe aGVHD or cGVHD, NRM, relapse, DFS, or OS. Multivariate analysis of the MSD and MUD groups failed to show an association between CD3 T cell dose and the risk of either aGVHD grade II-IV (P =.10 and.07, respectively) or cGVHD (P =.80 and.30, respectively). Subanalysis of CD4 T cells, CD8 T cells, and CD4+/CD8+ ratio failed to identify cutoff values predictive of transplantation outcomes; however, using the log-rank test, the sample size was suboptimal for identifying a difference at this cutoff cell dose. In this registry study, the CD3 T cell dose of PBSC products did not influence the risk of aGVHD or cGVHD or other transplantation outcomes when using an MSD or an 8/8-matched MUD. Subset analyses of CD4 and CD8 T cell doses were not possible given our small sample size.
publishDate	2019
dc.date.none.fl_str_mv	2 2019-01-01 2019 2019-01-01
dc.type.none.fl_str_mv	Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	https://ddd.uab.cat/record/286452 https://dx.doi.org/urn:doi:10.1016/j.bbmt.2019.05.007
url	https://ddd.uab.cat/record/286452 https://dx.doi.org/urn:doi:10.1016/j.bbmt.2019.05.007
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.source.none.fl_str_mv	reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona
instname_str	Universitat Autònoma de Barcelona
reponame_str	Dipòsit Digital de Documents de la UAB
collection	Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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spelling	Impact of T Cell Dose on Outcome of T Cell-Replete HLA-Matched Allogeneic Peripheral Blood Stem Cell TransplantationSaad, Ayman\|\|\|0000-0003-0003-0130Lamb, Lawrence\|\|\|0000-0001-7180-0994Wang, Tao\|\|\|0000-0002-1323-8697Hemmer, Michael T.Spellman, Stephen\|\|\|0000-0002-7271-8252Couriel, Daniel R.\|\|\|0000-0001-8167-4282Alousi, AminPidala, JosephAbdel-Azim, HishamAgrawal, Vaibhav\|\|\|0000-0002-6383-3777Aljurf, Mahmoud\|\|\|0000-0003-3942-7370Beitinjaneh, Amer\|\|\|0000-0002-1661-5865Bhatt, Vijaya Raj\|\|\|0000-0003-2513-0533Buchbinder, David KyleByrne, MichaelCahn, Jean-YvesCairo, Mitchell S.Castillo, Paul A.Chhabra, Saurabh\|\|\|0000-0001-9117-8696Diaz, Miguel AngelFarhan, Shatha\|\|\|0000-0002-5723-7442Floisand, Yngvar\|\|\|0000-0001-7267-1944Frangoul, Haydar A.Gadalla, Shahinaz M.\|\|\|0000-0002-3255-8143Gajewski, JamesGale, Robert Peter\|\|\|0000-0002-9156-1676Gandhi, ManishGergis, Usama\|\|\|0000-0003-0656-7385Hamilton, Betty\|\|\|0000-0003-1252-6539Hematti, Peiman\|\|\|0000-0001-5836-4497Hildebrandt, Gerhard C.Kamble, Rammurti T.Kanate, Abraham S.Khandelwal, PoojaLazaryn, AleksandrMacMillan, Margaret\|\|\|0000-0002-0755-0852Marks, David I.Martino Bofarull, Rodrigo\|\|\|0000-0001-5143-4042Mehta, Parinda A.Nishihori, Taiga\|\|\|0000-0002-2621-7924Olsson, Richard\|\|\|0000-0001-5970-2128Patel, Sagar\|\|\|0000-0001-9949-3615Qayed, Muna\|\|\|0000-0001-7689-343XRangarajan, Hemalatha G.Reshef, R.Ringden, Olle\|\|\|0000-0002-6092-1536Savani, Bipin\|\|\|0000-0002-3304-9965Schouten, H.C.Schultz, K.R.Seo, Sachiko\|\|\|0000-0002-4308-2152Shaffer, B.C.Solh, M.Teshima, T.Urbano Ispizua, Álvaro\|\|\|0000-0002-7529-9399Verdonck, L.F.Vij, R.Waller, Edmund K.\|\|\|0000-0003-0816-6729William, BasemWirk, Baldeep MonaYared, Jean A.Yu, L.C.Arora, Mukta\|\|\|0000-0001-9362-0556Hashmi, S.AllogeneicGVHD doseT cellTransplantationData on whether the T cell dose of allogeneic peripheral blood stem cell (PBSC) products influences transplantation outcomes are conflicting. Using the Center for International Blood and Marrow Transplant Research database, we identified 2736 adult patients who underwent first allogeneic PBSC transplantation for acute leukemia or myelodysplastic syndrome between 2008 and 2014 using an HLA-matched sibling donor (MSD) or an 8/8-matched unrelated donor (MUD). We excluded ex vivo and in vivo T cell-depleted transplantations. Correlative analysis was performed between CD3 T cell dose and the risk of graft-versus-host-disease (GVHD), relapse, nonrelapse mortality (NRM), disease-free survival (DFS), and overall survival (OS). Using maximum likelihood estimation, we identified CD3 T cell dose cutoff that separated the risk of acute GVHD (aGVHD) grade II-IV in both the MSD and MUD groups. A CD3 T cell dose cutoff of 14 × 10 cells/kg identified MSD/low CD3 (n = 223) and MSD/high CD3 (n = 1214), and a dose of 15 × 10 cells/kg identified MUD/low CD3 (n = 197) and MUD/high CD3 (n = 1102). On univariate analysis, the MSD/high CD3 group had a higher cumulative incidence of day +100 aGVHD grade II-IV compared with the MSD/low CD3 group (33% versus 25%; P =.009). There were no differences between the 2 groups in engraftment rate, risk of aGVHD grade III-IV or chronic GVHD (cGVHD), NRM, relapse, DFS, or OS. The MUD/high CD3 group had a higher cumulative incidence of day +100 aGVHD grade II-IV compared with the MUD/low CD3 group (49% versus 41%; P =.04). There were no differences between the 2 groups in engraftment rate, risk of severe aGVHD or cGVHD, NRM, relapse, DFS, or OS. Multivariate analysis of the MSD and MUD groups failed to show an association between CD3 T cell dose and the risk of either aGVHD grade II-IV (P =.10 and.07, respectively) or cGVHD (P =.80 and.30, respectively). Subanalysis of CD4 T cells, CD8 T cells, and CD4+/CD8+ ratio failed to identify cutoff values predictive of transplantation outcomes; however, using the log-rank test, the sample size was suboptimal for identifying a difference at this cutoff cell dose. In this registry study, the CD3 T cell dose of PBSC products did not influence the risk of aGVHD or cGVHD or other transplantation outcomes when using an MSD or an 8/8-matched MUD. Subset analyses of CD4 and CD8 T cell doses were not possible given our small sample size.Universitat Autònoma de Barcelona 22019-01-0120192019-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/286452https://dx.doi.org/urn:doi:10.1016/j.bbmt.2019.05.007reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2864522026-06-06T12:50:31Z
score	15.301603

Impact of T Cell Dose on Outcome of T Cell-Replete HLA-Matched Allogeneic Peripheral Blood Stem Cell Transplantation

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