PTCY and Tacrolimus for GVHD prevention for older adults undergoing HLA-matched sibling and unrelated donor alloHCT

The use of post-transplantation cyclophosphamide (PTCY) for graft-versus-host disease (GHVD) prevention is becoming prevalent in the transplantation community when HLA-identical sibling and 10/10 HLA-matched (MUD) and 9/10 mismatched unrelated donors are selected for alloHSCT. However, reported evid...

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Autores: Salas, María Queralt|||0000-0003-4567-3682, Charry, Paola|||0000-0002-4777-9643, Pedraza, Alexandra|||0000-0002-6039-8140, Martínez-Cibrian, N.uria, Solano, Maria Teresa, Domènech, Ariadna, Suárez-Lledó, Maria, Nomdedeu, Meritxell, Cid, Joan|||0000-0001-5445-4508, Lozano, Miquel|||0000-0003-2593-833X, de Llobet, Noemí, Arcarons, Jordi|||0000-0002-1356-6260, Rosiñol, Laura|||0000-0002-2534-9239, Gutiérrez-García, Gonzalo|||0000-0003-4084-8279, Carreras, Enric|||0000-0002-3134-9964, Esteve Reyner, Jordi|||0000-0002-8056-648X, Urbano Ispizua, Álvaro|||0000-0002-7529-9399, Fernandez Aviles, Francesc|||0000-0003-3051-3926, Rovira Argelagués, Montserrat|||0000-0001-7786-9079, Martínez, Carmen|||0000-0002-8401-7306
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:289949
Acceso en línea:https://ddd.uab.cat/record/289949
https://dx.doi.org/urn:doi:10.1016/j.jtct.2022.05.009
Access Level:acceso abierto
Palabra clave:Allogeneic hematopoietic stem cell transplantation
Post-transplant cyclophosphamide
Adults
Older adults
GVHD
GRFS
Descripción
Sumario:The use of post-transplantation cyclophosphamide (PTCY) for graft-versus-host disease (GHVD) prevention is becoming prevalent in the transplantation community when HLA-identical sibling and 10/10 HLA-matched (MUD) and 9/10 mismatched unrelated donors are selected for alloHSCT. However, reported evidence on outcomes from elderly patients receiving PTCY-containing GVHD prophylaxis remains limited. This study aims to compare the outcomes of PTCY- tacrolimus (TK) prophylaxis and conventional GVHD prophylaxis in patients aged.

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