Gemini histidine based surfactants: Characterization; surface properties and biological activity

New gemini cationic surfactants bearing imidazolium groups as polar heads and alkyl chains of various lengths were prepared using the amino acid histidine as starting material. These surfactants were found to have very low cmc values and reduced the surface tension of water solutions with high effic...

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Detalles Bibliográficos
Autores: Pinazo Gassol, Aurora, Pons Pons, Ramon, Bustelo, Marta, Manresa, Ángeles, Morán, María del Carmen, Raluy, Miriam, Pérez, Lourdes
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2019
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/184031
Acceso en línea:http://hdl.handle.net/10261/184031
Access Level:acceso abierto
Palabra clave:DNA binding
Gemini surfactants
Histidine
Self-assembly
Langmuir monolayers
Antimicrobial activity
Hemolytic activity
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spelling Gemini histidine based surfactants: Characterization; surface properties and biological activityPinazo Gassol, AuroraPons Pons, RamonBustelo, MartaManresa, ÁngelesMorán, María del CarmenRaluy, MiriamPérez, LourdesDNA bindingGemini surfactantsHistidineSelf-assemblyLangmuir monolayersAntimicrobial activityHemolytic activityNew gemini cationic surfactants bearing imidazolium groups as polar heads and alkyl chains of various lengths were prepared using the amino acid histidine as starting material. These surfactants were found to have very low cmc values and reduced the surface tension of water solutions with high efficiency. Their biological properties, antimicrobial and hemolytic activities, depended on the alkyl chain length. These surfactants are active against a wide range of bacteria including methicillin-resistant Staphylococcus aureus (MRSA). Moreover, these gemini surfactants have good DNA binding capacity. These new gemini surfactants show a great potential in cosmetic, food and pharmaceutical industries.This work was financed by the Ministerio de Economía y Competitividad, Spain, grants CTQ2017-88948-P and CTQ2014-59632-R. Authors also thank AGAUR 2017 SGR 670.Peer reviewedElsevierMinisterio de Economía y Competitividad (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]201920192019info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionhttp://hdl.handle.net/10261/184031reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2014-59632-Rhttps://doi.org/10.1016/j.molliq.2019.111156Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1840312026-05-22T06:33:51Z
dc.title.none.fl_str_mv Gemini histidine based surfactants: Characterization; surface properties and biological activity
title Gemini histidine based surfactants: Characterization; surface properties and biological activity
spellingShingle Gemini histidine based surfactants: Characterization; surface properties and biological activity
Pinazo Gassol, Aurora
DNA binding
Gemini surfactants
Histidine
Self-assembly
Langmuir monolayers
Antimicrobial activity
Hemolytic activity
title_short Gemini histidine based surfactants: Characterization; surface properties and biological activity
title_full Gemini histidine based surfactants: Characterization; surface properties and biological activity
title_fullStr Gemini histidine based surfactants: Characterization; surface properties and biological activity
title_full_unstemmed Gemini histidine based surfactants: Characterization; surface properties and biological activity
title_sort Gemini histidine based surfactants: Characterization; surface properties and biological activity
dc.creator.none.fl_str_mv Pinazo Gassol, Aurora
Pons Pons, Ramon
Bustelo, Marta
Manresa, Ángeles
Morán, María del Carmen
Raluy, Miriam
Pérez, Lourdes
author Pinazo Gassol, Aurora
author_facet Pinazo Gassol, Aurora
Pons Pons, Ramon
Bustelo, Marta
Manresa, Ángeles
Morán, María del Carmen
Raluy, Miriam
Pérez, Lourdes
author_role author
author2 Pons Pons, Ramon
Bustelo, Marta
Manresa, Ángeles
Morán, María del Carmen
Raluy, Miriam
Pérez, Lourdes
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Economía y Competitividad (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv DNA binding
Gemini surfactants
Histidine
Self-assembly
Langmuir monolayers
Antimicrobial activity
Hemolytic activity
topic DNA binding
Gemini surfactants
Histidine
Self-assembly
Langmuir monolayers
Antimicrobial activity
Hemolytic activity
description New gemini cationic surfactants bearing imidazolium groups as polar heads and alkyl chains of various lengths were prepared using the amino acid histidine as starting material. These surfactants were found to have very low cmc values and reduced the surface tension of water solutions with high efficiency. Their biological properties, antimicrobial and hemolytic activities, depended on the alkyl chain length. These surfactants are active against a wide range of bacteria including methicillin-resistant Staphylococcus aureus (MRSA). Moreover, these gemini surfactants have good DNA binding capacity. These new gemini surfactants show a great potential in cosmetic, food and pharmaceutical industries.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/184031
url http://hdl.handle.net/10261/184031
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2014-59632-R
https://doi.org/10.1016/j.molliq.2019.111156
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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