Gemini histidine based surfactants: Characterization; surface properties and biological activity
New gemini cationic surfactants bearing imidazolium groups as polar heads and alkyl chains of various lengths were prepared using the amino acid histidine as starting material. These surfactants were found to have very low cmc values and reduced the surface tension of water solutions with high effic...
| Autores: | , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión aceptada para publicación |
| Fecha de publicación: | 2019 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/184031 |
| Acceso en línea: | http://hdl.handle.net/10261/184031 |
| Access Level: | acceso abierto |
| Palabra clave: | DNA binding Gemini surfactants Histidine Self-assembly Langmuir monolayers Antimicrobial activity Hemolytic activity |
| Sumario: | New gemini cationic surfactants bearing imidazolium groups as polar heads and alkyl chains of various lengths were prepared using the amino acid histidine as starting material. These surfactants were found to have very low cmc values and reduced the surface tension of water solutions with high efficiency. Their biological properties, antimicrobial and hemolytic activities, depended on the alkyl chain length. These surfactants are active against a wide range of bacteria including methicillin-resistant Staphylococcus aureus (MRSA). Moreover, these gemini surfactants have good DNA binding capacity. These new gemini surfactants show a great potential in cosmetic, food and pharmaceutical industries. |
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