Alcoholic Liver Disease Among Patients with Wernicke Encephalopathy
Background: data regarding the association between Wernicke encephalopathy (WE) and alcoholic liver disease (ALD) are scarce in spite of alcohol consumption being the main risk factor for WE. Aims: to describe the frequency of ALD in a cohort of patients diagnosed with WE and alcohol use disorders (...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2022 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:293955 |
| Acceso en línea: | https://ddd.uab.cat/record/293955 https://dx.doi.org/urn:doi:10.1016/j.drugalcdep.2021.109186 |
| Access Level: | acceso abierto |
| Palabra clave: | Wernicke encephalopathy Alcoholic liver disease Alcohol use disorders |
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Alcoholic Liver Disease Among Patients with Wernicke EncephalopathyA Multicenter Observational StudyNovo-Veleiro, Ignacio|||0000-0003-0948-2440Herrera Flores, JavierRosón-Hernández, Beatriz|||0000-0003-3568-2294Medina-García, José-A.Muga, Roberto|||0000-0001-6301-431XFernández-Solá, Joaquim|||0000-0002-3218-0582Martín-González, M.Seco-Hernández, ElenaSuárez-Cuervo, CarlosMateos-Díaz, Ana-M.Monte-Secades, Rafael|||0000-0003-4257-2712Machado-Prieto, BegoñaPuerta-Louro, RubénPrada González, Cristina|||0000-0002-5780-0047Fernández-Rial, ÁlvaroSabio Repiso, Patricia|||0000-0002-1878-8794Vázquez-Vigo, RocíoAntolí-Royo, Ana Cristina|||0000-0001-6273-9618Gomila, Aina|||0000-0001-6979-9269Felipe-Pérez, Nieves CSanvisens-Bergé, ArantzaAntúnez-Jorge, EmiliaFernández-Rodríguez, Camino M.Alvela-Suárez, LuciaFidalgo-Navarro, AlbaCastro, Joaquín|||0000-0001-6248-3114Polvorosa-Gómez, María A.Del Valle-Sánchez, MarioLópez-Castro, José|||0000-0002-8402-3423Chamorro, Antonio-J.|||0000-0002-2345-2873Marcos, Miguel|||0000-0003-1269-4487Wernicke encephalopathyAlcoholic liver diseaseAlcohol use disordersBackground: data regarding the association between Wernicke encephalopathy (WE) and alcoholic liver disease (ALD) are scarce in spite of alcohol consumption being the main risk factor for WE. Aims: to describe the frequency of ALD in a cohort of patients diagnosed with WE and alcohol use disorders (AUDs) and to compare the characteristics of WE patients with and without ALD. Methods: we conducted an observational study in 21 centers through a nationwide registry of the Spanish Society of Internal Medicine. WE Caine criteria were applied and demographic, clinical, and outcome variables were analyzed. Results: 434 patients were included in the study, of which 372 were men (85.7%), and the mean age was 55 ± 11.8 years. ALD was present in 162 (37.3%) patients and we found a higher percentage of cases with tremor, flapping and hallucinations in the ALD group. A total of 22 patients (5.0%) died during admission (7.4% with ALD vs 3.7% without ALD; P = 0.087). Among the ALD patients, a relationship between mortality and the presence of anemia (Odds ratio [OR]=4.6 Confidence interval [CI]95% 1.1-18.8; P = 0.034), low level of consciousness (OR=4.9 CI95% 1.1-21.2; P = 0.031) and previous diagnosis of cancer (OR=10.3 CI95% 1.8-59.5; P = 0.009) was detected. Complete recovery was achieved by 27 patients with ALD (17.8%) and 71 (27.8%) without ALD (P = 0.030). Conclusion: the association of WE and ALD in patients with AUDs is frequent and potentially linked to differences in clinical presentation and to poorer prognosis, as compared to alcoholic patients with WE without ALD.Universitat Autònoma de Barcelona. Departament de Medicina 22022-01-0120222022-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/293955https://dx.doi.org/urn:doi:10.1016/j.drugalcdep.2021.109186reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengMinisterio de Economía y Competitividad https://doi.org/10.13039/501100003329 RD16/0017/0023Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 RD16/0017/0003Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 RD16/0017/0018open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2939552026-06-06T12:50:31Z |
| dc.title.none.fl_str_mv |
Alcoholic Liver Disease Among Patients with Wernicke Encephalopathy A Multicenter Observational Study |
| title |
Alcoholic Liver Disease Among Patients with Wernicke Encephalopathy |
| spellingShingle |
Alcoholic Liver Disease Among Patients with Wernicke Encephalopathy Novo-Veleiro, Ignacio|||0000-0003-0948-2440 Wernicke encephalopathy Alcoholic liver disease Alcohol use disorders |
| title_short |
Alcoholic Liver Disease Among Patients with Wernicke Encephalopathy |
| title_full |
Alcoholic Liver Disease Among Patients with Wernicke Encephalopathy |
| title_fullStr |
Alcoholic Liver Disease Among Patients with Wernicke Encephalopathy |
| title_full_unstemmed |
Alcoholic Liver Disease Among Patients with Wernicke Encephalopathy |
| title_sort |
Alcoholic Liver Disease Among Patients with Wernicke Encephalopathy |
| dc.creator.none.fl_str_mv |
Novo-Veleiro, Ignacio|||0000-0003-0948-2440 Herrera Flores, Javier Rosón-Hernández, Beatriz|||0000-0003-3568-2294 Medina-García, José-A. Muga, Roberto|||0000-0001-6301-431X Fernández-Solá, Joaquim|||0000-0002-3218-0582 Martín-González, M. Seco-Hernández, Elena Suárez-Cuervo, Carlos Mateos-Díaz, Ana-M. Monte-Secades, Rafael|||0000-0003-4257-2712 Machado-Prieto, Begoña Puerta-Louro, Rubén Prada González, Cristina|||0000-0002-5780-0047 Fernández-Rial, Álvaro Sabio Repiso, Patricia|||0000-0002-1878-8794 Vázquez-Vigo, Rocío Antolí-Royo, Ana Cristina|||0000-0001-6273-9618 Gomila, Aina|||0000-0001-6979-9269 Felipe-Pérez, Nieves C Sanvisens-Bergé, Arantza Antúnez-Jorge, Emilia Fernández-Rodríguez, Camino M. Alvela-Suárez, Lucia Fidalgo-Navarro, Alba Castro, Joaquín|||0000-0001-6248-3114 Polvorosa-Gómez, María A. Del Valle-Sánchez, Mario López-Castro, José|||0000-0002-8402-3423 Chamorro, Antonio-J.|||0000-0002-2345-2873 Marcos, Miguel|||0000-0003-1269-4487 |
| author |
Novo-Veleiro, Ignacio|||0000-0003-0948-2440 |
| author_facet |
Novo-Veleiro, Ignacio|||0000-0003-0948-2440 Herrera Flores, Javier Rosón-Hernández, Beatriz|||0000-0003-3568-2294 Medina-García, José-A. Muga, Roberto|||0000-0001-6301-431X Fernández-Solá, Joaquim|||0000-0002-3218-0582 Martín-González, M. Seco-Hernández, Elena Suárez-Cuervo, Carlos Mateos-Díaz, Ana-M. Monte-Secades, Rafael|||0000-0003-4257-2712 Machado-Prieto, Begoña Puerta-Louro, Rubén Prada González, Cristina|||0000-0002-5780-0047 Fernández-Rial, Álvaro Sabio Repiso, Patricia|||0000-0002-1878-8794 Vázquez-Vigo, Rocío Antolí-Royo, Ana Cristina|||0000-0001-6273-9618 Gomila, Aina|||0000-0001-6979-9269 Felipe-Pérez, Nieves C Sanvisens-Bergé, Arantza Antúnez-Jorge, Emilia Fernández-Rodríguez, Camino M. Alvela-Suárez, Lucia Fidalgo-Navarro, Alba Castro, Joaquín|||0000-0001-6248-3114 Polvorosa-Gómez, María A. Del Valle-Sánchez, Mario López-Castro, José|||0000-0002-8402-3423 Chamorro, Antonio-J.|||0000-0002-2345-2873 Marcos, Miguel|||0000-0003-1269-4487 |
| author_role |
author |
| author2 |
Herrera Flores, Javier Rosón-Hernández, Beatriz|||0000-0003-3568-2294 Medina-García, José-A. Muga, Roberto|||0000-0001-6301-431X Fernández-Solá, Joaquim|||0000-0002-3218-0582 Martín-González, M. Seco-Hernández, Elena Suárez-Cuervo, Carlos Mateos-Díaz, Ana-M. Monte-Secades, Rafael|||0000-0003-4257-2712 Machado-Prieto, Begoña Puerta-Louro, Rubén Prada González, Cristina|||0000-0002-5780-0047 Fernández-Rial, Álvaro Sabio Repiso, Patricia|||0000-0002-1878-8794 Vázquez-Vigo, Rocío Antolí-Royo, Ana Cristina|||0000-0001-6273-9618 Gomila, Aina|||0000-0001-6979-9269 Felipe-Pérez, Nieves C Sanvisens-Bergé, Arantza Antúnez-Jorge, Emilia Fernández-Rodríguez, Camino M. Alvela-Suárez, Lucia Fidalgo-Navarro, Alba Castro, Joaquín|||0000-0001-6248-3114 Polvorosa-Gómez, María A. Del Valle-Sánchez, Mario López-Castro, José|||0000-0002-8402-3423 Chamorro, Antonio-J.|||0000-0002-2345-2873 Marcos, Miguel|||0000-0003-1269-4487 |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universitat Autònoma de Barcelona. Departament de Medicina |
| dc.subject.none.fl_str_mv |
Wernicke encephalopathy Alcoholic liver disease Alcohol use disorders |
| topic |
Wernicke encephalopathy Alcoholic liver disease Alcohol use disorders |
| description |
Background: data regarding the association between Wernicke encephalopathy (WE) and alcoholic liver disease (ALD) are scarce in spite of alcohol consumption being the main risk factor for WE. Aims: to describe the frequency of ALD in a cohort of patients diagnosed with WE and alcohol use disorders (AUDs) and to compare the characteristics of WE patients with and without ALD. Methods: we conducted an observational study in 21 centers through a nationwide registry of the Spanish Society of Internal Medicine. WE Caine criteria were applied and demographic, clinical, and outcome variables were analyzed. Results: 434 patients were included in the study, of which 372 were men (85.7%), and the mean age was 55 ± 11.8 years. ALD was present in 162 (37.3%) patients and we found a higher percentage of cases with tremor, flapping and hallucinations in the ALD group. A total of 22 patients (5.0%) died during admission (7.4% with ALD vs 3.7% without ALD; P = 0.087). Among the ALD patients, a relationship between mortality and the presence of anemia (Odds ratio [OR]=4.6 Confidence interval [CI]95% 1.1-18.8; P = 0.034), low level of consciousness (OR=4.9 CI95% 1.1-21.2; P = 0.031) and previous diagnosis of cancer (OR=10.3 CI95% 1.8-59.5; P = 0.009) was detected. Complete recovery was achieved by 27 patients with ALD (17.8%) and 71 (27.8%) without ALD (P = 0.030). Conclusion: the association of WE and ALD in patients with AUDs is frequent and potentially linked to differences in clinical presentation and to poorer prognosis, as compared to alcoholic patients with WE without ALD. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2 2022-01-01 2022 2022-01-01 |
| dc.type.none.fl_str_mv |
Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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info:eu-repo/semantics/article |
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article |
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https://ddd.uab.cat/record/293955 https://dx.doi.org/urn:doi:10.1016/j.drugalcdep.2021.109186 |
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https://ddd.uab.cat/record/293955 https://dx.doi.org/urn:doi:10.1016/j.drugalcdep.2021.109186 |
| dc.language.none.fl_str_mv |
Inglés eng |
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Inglés |
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eng |
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Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 RD16/0017/0023 Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 RD16/0017/0003 Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 RD16/0017/0018 |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by-nc-nd/4.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by-nc-nd/4.0/ |
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openAccess |
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application/pdf |
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reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona |
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Universitat Autònoma de Barcelona |
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